A team of researchers have spent the past eight years looking at better ways to transport organs for donation, specifically hearts, to improve the number of organs that can be used for transplants. They found that using a modified normothermic perfusion system heart preservation was feasible for up to 24 hours.

The newest version of the heparin reversal drug, described in a recent issue of Advanced Healthcare Materials, adjusted the number of protons bound to it, making the molecule less positive so it would preferentially bind to the highly negative heparin, resulting in a much safer drug.

Using human cells in an animal body, a team of researchers has developed a functional model of thoracic aortic aneurysm, creating opportunities for more effective understanding of disease development and treatments for the potentially fatal condition.

A patient who has received two heart transplants years apart shares his story and the importance of advocating for organ donation.

Today on The Fundamentals, our guest Dr. Martin Myers, Director of the U-M Elizabeth Weiser Caswell Diabetes Institute, discusses diabetes research in the context of Ozempic, Wegovy, and other drugs that are changing how people think about weight loss. You can learn more about Dr. Myers here, and you can follow the department of molecular and integrative physiology @UMPhysiology on X.

Today on The Fundamentals is Dr. Maria Castro, the R.C. Schneider collegiate professor of neurosurgery, and a professor of cell and developmental biology at the University of Michigan Medical School. Her research program aims to develop immunotherapies for primary and metastatic brain cancer, studying basic immune biology mechanisms leading to clinical implementation. She has been inducted into the American Association for the Advancement of Sciences, the Latin American Academy of Sciences, and the American Institute for Medical and Biological Engineering College of Fellows. She has won numerous awards for her contributions to basic science and cancer research and is a diversity ambassador for the Cancer Biology Graduate Training Program. You can learn more about Dr. Castro here, and you can follow her @castro2355_mg, the Rogel Cancer Center @UMRogelCancer, the department of neurosurgery @umichneuro, Michigan Neurscience Institute @UM_MNI and the department of cell and developmental biology @UMCDB on X

Experts discuss pregnancy and heart health.

Researchers improved memory and reduced neuroinflammation in a mouse model of Alzheimer’s Disease, suggesting another avenue for potential treatment.

Four faculty and two staff members from the departments of Anesthesiology, Neurology, Radiology and Surgery, and the Office of Graduate Medical Education (GME), are recipients of GME Awards for 2024

Among people with multiple sclerosis in the United States, more than half experienced at least one fall in a six-month period and approximately one-third of those falls resulted in an injury.

Complications during procedures only contributed to death in about 20% of cases.

A Michigan Medicine study finds that storing chemicals in a garage at home may associate with an increased risk of ALS.

Most people with risk factors for cardiovascular disease – what are sometimes called the Essential Eight – are managed by primary care clinics, or haven’t seen any provider recently

Around 10% of all deaths following percutaneous coronary intervention are potentially preventable, a study led by Michigan Medicine finds.

A growing number of people living with Alzheimer’s disease and related dementias – especially those from diverse backgrounds – receive care from a network of individuals that increasingly includes nontraditional informal caregivers.