Associate Research Scientist, Pharmacology
Associate Research Scientist, Life Sciences Institute
[email protected]
Available to mentor
Andrew J Alt
Associate Research Scientist
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Denomme N, Hernandez CC, Bock HA, Ohana RF, Bakshi S, Sherwood AM, McCorvy JD, Daley PF, Callaway WB, Hull JM, Alt A, Isom LL, Cozzi NV. Mol Pharmacol, 2024 Jul 17; 106 (2): 92 - 106.Journal ArticleN-(4-Bromo-2,5-Dimethoxyphenethyl)-6-(4-Phenylbutoxy)Hexan-1-Amine (XOB): A Novel Phenylalkylamine Antagonist of Serotonin 2A Receptors and Voltage-Gated Sodium Channels.
DOI:10.1124/molpharm.123.000837 PMID: 38821630 -
Qiu D, Xu K, Chung N, Robbins J, Luo R, Lawrence M, He A, Yu F, Alt A, Miller MM, Hangeland J, Feder JN, Seiffert D, Arey BJ. Front Mol Biosci, 2023 10: 1198079Journal ArticleIdentification and validation of G protein-coupled receptors modulating flow-dependent signaling pathways in vascular endothelial cells.
DOI:10.3389/fmolb.2023.1198079 PMID: 37363403 -
Olson KM, Campbell A, Alt A, Traynor JR. ACS Pharmacol Transl Sci, 2022 Sep 9; 5 (9): 694 - 709.Journal ArticleFinding the Perfect Fit: Conformational Biosensors to Determine the Efficacy of GPCR Ligands.
DOI:10.1021/acsptsci.1c00256 PMID: 36110374 -
Tsou P-S, Lu C, Gurrea-Rubio M, Muraoka S, Campbell PL, Wu Q, Model EN, Lind ME, Vichaikul S, Mattichak MN, Brodie WD, Hervoso JL, Ory S, Amarista CI, Pervez R, Junginger L, Ali M, Hodish G, O'Mara MM, Ruth JH, Robida AM, Alt AJ, Zhang C, Urquhart AG, Lawton JN, Chung KC, Maerz T, Saunders TL, Groppi VE, Fox DA, Amin MA. J Clin Invest, 2022 Jun 1; 132 (11):Journal ArticleSoluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
DOI:10.1172/JCI151827 PMID: 35439173 -
Tsou PS, Lu C, Gurrea-Rubio M, Muraoka S, Campbell PL, Wu Q, Model EN, Lind ME, Vichaikul S, Mattichak MN, Brodie WD, Hervoso JL, Ory S, Amarista CI, Pervez R, Junginger L, Ali M, Hodish G, O'Mara MM, Ruth JH, Robida AM, Alt AJ, Zhang C, Urquhart AG, Lawton JN, Chung KC, Maerz T, Saunders TL, Groppi VE, Fox DA, Amin MA. The Journal of clinical investigation, 2022 Jun 1; 132 (11): e151827 - e151827.Journal ArticleSoluble CD13 induces inflammatory arthritis by activating the bradykinin receptor B1.
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Olson KM, Traynor JR, Alt A. Front Chem, 2021 9: 671483Journal ArticleAllosteric Modulator Leads Hiding in Plain Site: Developing Peptide and Peptidomimetics as GPCR Allosteric Modulators.
DOI:10.3389/fchem.2021.671483 PMID: 34692635 -
Kandasamy R, Hillhouse TM, Livingston KE, Kochan KE, Meurice C, Eans SO, Li M-H, White AD, Roques BP, McLaughlin JP, Ingram SL, Burford NT, Alt A, Traynor JR. Proc Natl Acad Sci U S A, 2021 Apr 20; 118 (16):Journal ArticlePositive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
DOI:10.1073/pnas.2000017118 PMID: 33846240 -
Scott CE, Tang Y, Alt A, Burford NT, Gerritz SW, Ogawa LM, Zhang L, Kendall DA. Eur J Pharmacol, 2019 Jul 5; 854: 1 - 8.Journal ArticleIdentification and biochemical analyses of selective CB2 agonists.
DOI:10.1016/j.ejphar.2019.03.054 PMID: 30951717
Department News
Dr. Andy Alt receives the OVPR Faculty Achievement Award
Department News
Faculty Promotions (effective September 1, 2023) at the U-M Medical School Department of Pharmacology
