Harry L Mobley, PhD
Frederick G Novy Distinguished University Professor of Microbiology and Immunology
Frederick Novy Collegiate Professor and Professor of Microbiology and Immunology
Microbiology and Immunology
1500 E. Medical Center Drive
Ann Arbor, MI 48109
[email protected]

Available to mentor

Harry L Mobley, PhD
Professor
  • About
  • Links
  • Qualifications
  • Research Overview
  • Recent Publications
  • About

    Dr. Mobley received his PhD at the University of Louisville School of Medicine and conducted postdoctoral work at the University of Maryland School of Medicine in Biochemistry and Vaccine Development, after which he joined the faculty in the Division of Infectious Diseases and rose to the rank of Professor of Microbiology and Immunology. After 23 years at Maryland, Dr. Mobley was named Chair of the Department of Microbiology and Immunology at the University of Michigan Medical School in 2004, serving in this role until 2019. Dr. Mobley’s research focuses on uropathogenic E. coli and Proteus mirabilis, but has also studied Helicobacter pylori and Gram-negative bacterial species causing bacteremia including E. coli, Klebsiella pneumoniae, Acinetobacter baumannii, Citrobacter freundii, and Serratia marcescens.

    Links
    • Mobley Lab
    Qualifications
    • Biochemistry
      University of Maryland School of Medicine, Department of Biological Chemistry, 1984
    • Bacterial Genetics
      University of Maryland School of Medicine, Center for Vaccine Development, 1984
    • PhD
      University of Louisville School of Medicine, Louisville, 1981
    • MS
      University of Louisville School of Medicine, Louisville, 1977
    • BS
      Emory University School of Medicine, Atlanta, 1975
    Research Overview

    Molecular mechanisms of bacterial pathogenesis of urinary tract infection and bacteremia; bacterial genetics; E. coli, Proteus mirabilis, Acinetobacter baumannii

    Recent Publications See All Publications
    • Journal Article
      Iron limitation induces motility in uropathogenic E. coli CFT073 partially through action of LpdA.
      Frick-Cheng AE, Shea AE, Roberts JR, Smith SN, Ohi MD, Mobley HLT. mBio, 2024 Jul 17; 15 (7): e0104824 DOI:10.1128/mbio.01048-24
      PMID: 38874412
    • Journal Article
      PD63-04 ASYMPTOMATIC BACTERIURIA DIAGNOSTICS FOR LOW RESOURCE SETTINGS USING A MODIFIED WATER QUALITY TEST KIT
      Fleck RC, Stocki JA, Nguyen IB, Walde R, Mobley HLT, Shea AE. Journal of Urology, 2024 May; 211 (5S): e1293 DOI:10.1097/01.ju.0001009384.23104.ca.04
    • Presentation
      Bacteremia Fitness Factors in Gram-Negative Bacilli
      Mobley H. 2024 Apr 27;
    • Journal Article
      Emerging roles for ABC transporters as virulence factors in uropathogenic Escherichia coli.
      Shea AE, Forsyth VS, Stocki JA, Mitchell TJ, Frick-Cheng AE, Smith SN, Hardy SL, Mobley HLT. Proc Natl Acad Sci U S A, 2024 Apr 16; 121 (16): e2310693121 DOI:10.1073/pnas.2310693121
      PMID: 38607934
    • Journal Article
      Proteus mirabilis UreR coordinates cellular functions required for urease activity.
      Fitzgerald MJ, Pearson MM, Mobley HLT. J Bacteriol, 2024 Apr 18; 206 (4): e0003124 DOI:10.1128/jb.00031-24
      PMID: 38534115
    • Preprint
      Fitness Factor Genes Conserved within the Multi-species Core Genome of Gram-negative Enterobacterales Species Contribute to Bacteremia Pathogenesis
      Mobley HLT, Anderson MT, Moricz BS, Severin GB, Holmes CL, Ottosen EN, Eichler T, Gupta S, Paudel S, Sinha R, Mason S, Himpsl SD, Brown AN, Gaca M, Kiser CM, Clarke TH, Fouts DE, DiRita VJ, Bachman MA. bioRxiv, DOI:10.1101/2024.03.18.585282
    • Journal Article
      Organ agar serves as physiologically relevant alternative for in vivo bacterial colonization.
      Pearson MM, Shea AE, Pahil S, Smith SN, Forsyth VS, Mobley HLT. Infect Immun, 2023 Nov 16; 91 (11): e0035523 DOI:10.1128/iai.00355-23
      PMID: 37850748
    • Journal Article
      Conserved metabolic regulator ArcA responds to oxygen availability, iron limitation, and cell envelope perturbations during bacteremia.
      Brown AN, Anderson MT, Smith SN, Bachman MA, Mobley HLT. mBio, 2023 Oct 31; 14 (5): e0144823 DOI:10.1128/mbio.01448-23
      PMID: 37681955
    Featured News & Stories Left to right: Surbhi Gupta (University of Michigan), Laura Mike (University of Pittsburgh), Harry Mobley (University of Michigan), Melanie Pearson (University of Michigan), Chelsie Armbruster (SUNY Buffalo), and Allyson Shea (University of South Alabama)
    Department News
    Harry Mobley receives a Lifetime Achievement Award from the Urinary Tract Infection Global Alliance (UTIGA)
    Harry Mobley receives the Lifetime Achievement Award at the 5th Clinical and Scientific Advances in Urinary Tract Infections held July 19-21 in Columbus, Ohio
    Department News
    Aric Brown will defend his dissertation
    Aric Brown will defend his dissertation