Professor Emeritus of Biological Chemistry and Research Professor Emeritus, Michigan Neuroscience Institute
[email protected]
Available to mentor
Michael D Uhler
Professor Emeritus/a
The Uhler lab research is focused on the signal transduction systems that function in the nervous system and components of those systems that are altered in human diseases. Recently, we have used human stem cells and their neuronal development to study the biochemical and genetic interactions that are disrupted in depression, epilepsy and aging.
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Center MemberEisenberg Family Depression Center
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Center MemberCenter for Computational Medicine and Bioinformatics
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Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. STAR Protoc, 2023 Dec 15; 4 (4): 102629Journal ArticleProtocol for selecting single human pluripotent stem cells using a modified micropipetter.
DOI:10.1016/j.xpro.2023.102629 PMID: 37804512 -
Schultz ML, Schache KJ, Azaria RD, Kuiper EQ, Erwood S, Ivakine EA, Farhat NY, Porter FD, Pathmasiri KC, Cologna SM, Uhler MD, Lieberman AP. JCI Insight, 2022 Dec 8; 7 (23):Journal ArticleSpecies-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease.
DOI:10.1172/jci.insight.160308 PMID: 36301667 -
Morton SU, Sefton CR, Zhang H, Dai M, Turner DL, Uhler MD, Agrawal PB. Int J Mol Sci, 2021 Mar 7; 22 (5):Journal ArticlemicroRNA-mRNA Profile of Skeletal Muscle Differentiation and Relevance to Congenital Myotonic Dystrophy.
DOI:10.3390/ijms22052692 PMID: 33799993 -
Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M. J Neurochem, 2018 May; 145 (3): 188 - 203.Journal ArticleFibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons.
DOI:10.1111/jnc.14255 PMID: 29168882 -
Tidball AM, Dang LT, Glenn TW, Kilbane EG, Klarr DJ, Margolis JL, Uhler MD, Parent JM. Stem Cell Reports, 2017 Sep 12; 9 (3): 725 - 731.Journal ArticleRapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing.
DOI:10.1016/j.stemcr.2017.07.003 PMID: 28781079 -
Gupta S, Redmond T, Meng F, Uhler M. The FASEB Journal, 2017 Apr; 31 (S1):Proceeding / Abstract / PosterPotential mechanisms of the antidepressant effects of FGF2: Gene expression changes in postmitotic human excitatory neurons
DOI:10.1096/fasebj.31.1_supplement.936.8 -
Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. Cell Metab, 2016 Mar 8; 23 (3): 505 - 516.Journal ArticleHIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
DOI:10.1016/j.cmet.2016.01.004 PMID: 26853750 -
Huang HS, Redmond TM, Kubish GM, Gupta S, Thompson RC, Turner DL, Uhler MD. J Mol Neurosci, 2015 Mar; 55 (3): 684 - 705.Journal ArticleTranscriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.
DOI:10.1007/s12031-014-0408-2 PMID: 25189318
Department News
UM Biological Chemistry Professor Emeritus Michael Uhler receives MICHR Distinguished Mentor Award.
Department News
Congratulations and best wishes to Michael Uhler, PhD, Professor Emeritus of Biological Chemistry and Research Professor Emeritus, Michigan Neuroscience Institute.
