Michael D Uhler
Professor of Biological Chemistry
Research Professor
Michigan Neuroscience Institute
[email protected]

Available to mentor

Michael D Uhler
Research Professor
  • About
  • Center Memberships
  • Recent Publications
  • About

    The Uhler lab research is focused on the signal transduction systems that function in the nervous system and components of those systems that are altered in human diseases. Recently, we have used human stem cells and their neuronal development to study the biochemical and genetic interactions that are disrupted in depression, epilepsy and aging.

    Center Memberships
    • Center Member
      Eisenberg Family Depression Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    Recent Publications See All Publications
    • Journal Article
      Protocol for selecting single human pluripotent stem cells using a modified micropipetter.
      Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. STAR Protoc, 2023 Dec 15; 4 (4): 102629 DOI:10.1016/j.xpro.2023.102629
      PMID: 37804512
    • Journal Article
      Species-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease.
      Schultz ML, Schache KJ, Azaria RD, Kuiper EQ, Erwood S, Ivakine EA, Farhat NY, Porter FD, Pathmasiri KC, Cologna SM, Uhler MD, Lieberman AP. JCI Insight, 2022 Dec 8; 7 (23): DOI:10.1172/jci.insight.160308
      PMID: 36301667
    • Journal Article
      microRNA-mRNA Profile of Skeletal Muscle Differentiation and Relevance to Congenital Myotonic Dystrophy.
      Morton SU, Sefton CR, Zhang H, Dai M, Turner DL, Uhler MD, Agrawal PB. Int J Mol Sci, 2021 Mar 7; 22 (5): DOI:10.3390/ijms22052692
      PMID: 33799993
    • Journal Article
      Fibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons.
      Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M. J Neurochem, 2018 May; 145 (3): 188 - 203. DOI:10.1111/jnc.14255
      PMID: 29168882
    • Journal Article
      Rapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing.
      Tidball AM, Dang LT, Glenn TW, Kilbane EG, Klarr DJ, Margolis JL, Uhler MD, Parent JM. Stem Cell Reports, 2017 Sep 12; 9 (3): 725 - 731. DOI:10.1016/j.stemcr.2017.07.003
      PMID: 28781079
    • Proceeding / Abstract / Poster
      Potential mechanisms of the antidepressant effects of FGF2: Gene expression changes in postmitotic human excitatory neurons
      Gupta S, Redmond T, Meng F, Uhler M. The FASEB Journal, 2017 Apr; 31 (S1): DOI:10.1096/fasebj.31.1_supplement.936.8
    • Journal Article
      HIF2α Is an Essential Molecular Brake for Postprandial Hepatic Glucagon Response Independent of Insulin Signaling.
      Ramakrishnan SK, Zhang H, Takahashi S, Centofanti B, Periyasamy S, Weisz K, Chen Z, Uhler MD, Rui L, Gonzalez FJ, Shah YM. Cell Metab, 2016 Mar 8; 23 (3): 505 - 516. DOI:10.1016/j.cmet.2016.01.004
      PMID: 26853750
    • Journal Article
      Transcriptional regulatory events initiated by Ascl1 and Neurog2 during neuronal differentiation of P19 embryonic carcinoma cells.
      Huang HS, Redmond TM, Kubish GM, Gupta S, Thompson RC, Turner DL, Uhler MD. J Mol Neurosci, 2015 Mar; 55 (3): 684 - 705. DOI:10.1007/s12031-014-0408-2
      PMID: 25189318