Professor Emeritus of Biological Chemistry and Research Professor Emeritus
Michigan Neuroscience Institute
Medical School
[email protected]
Available to mentor
Michael D Uhler
Professor Emeritus/a
The Uhler lab research is focused on the signal transduction systems that function in the nervous system and components of those systems that are altered in human diseases. Recently, we have used human stem cells and their neuronal development to study the biochemical and genetic interactions that are disrupted in depression, epilepsy and aging.
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Center MemberEisenberg Family Depression Center
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Center MemberCenter for Computational Medicine and Bioinformatics
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Parent R, Lin RL, Ouillette L, Glass E, Burns H, Uhler MD, Case SL, Thibault O, Murphy GG. Biological Psychiatry Global Open Science, 2025 Sep 1; 5 (5):Journal ArticleThe Impact of Overexpression of the Mouse Ortholog of CACNA1C on Behavior and Cortical Dynamics
DOI:10.1016/j.bpsgos.2025.100537 -
Mojica-Perez SP, Stokes K, Jaklic DC, Jahagirdar S, Uhler M, Parent JM, Niu W. STAR Protocols, 2023 Dec 15; 4 (4):Journal ArticleProtocol for selecting single human pluripotent stem cells using a modified micropipetter
DOI:10.1016/j.xpro.2023.102629 PMID: 37804512 -
Verma I, Yuan Y, Lopez-Santiago L, Uhler M, Isom L, Parent J. 2023 Jun 14;Proceeding / Abstract / PosterHuman Induced Pluripotent Stem Cell Model to Study Interneuron Defects in Dravet Syndrome
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Schultz ML, Schache KJ, Azaria RD, Kuiper EQ, Erwood S, Ivakine EA, Farhat NY, Porter FD, Pathmasiri KC, Cologna SM, Uhler MD, Lieberman AP. Jci Insight, 2022 Dec 8; 7 (23):Journal ArticleSpecies-specific differences in NPC1 protein trafficking govern therapeutic response in Niemann-Pick type C disease
DOI:10.1172/jci.insight.160308 PMID: 36301667 -
Yuan Y, Verma I, Uhler M, Lopez-Santiago L, Parent J, Isom L. 2022 Dec 1;Proceeding / Abstract / PosterElectrophysiological characterization of human SCN1A+/- iPSC-derived, non-parvalbumin- expressing interneurons.
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Morton SU, Sefton CR, Zhang H, Dai M, Turner DL, Uhler MD, Agrawal PB. International Journal of Molecular Sciences, 2021 Mar 1; 22 (5): 1 - 15.Journal ArticleMicrorna-mrna profile of skeletal muscle differentiation and relevance to congenital myotonic dystrophy
DOI:10.3390/ijms22052692 PMID: 33799993 -
Gupta S, M-Redmond T, Meng F, Tidball A, Akil H, Watson S, Parent JM, Uhler M. Journal of Neurochemistry, 2018 May 1; 145 (3): 188 - 203.Journal ArticleFibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons
DOI:10.1111/jnc.14255 PMID: 29168882 -
Dang L, Swaminathan P, Liu Y, Tidball A, Klarr D, Parent M, Lopez-Santiago L, Yuan Y, Uhler M, Isom L, Parent J. 2017 Oct 3;Proceeding / Abstract / PosterUsing Dravet Syndrome patient-specific neurons to screen for effective anti-seizure medications
Department News
UM Biological Chemistry Professor Emeritus Michael Uhler receives MICHR Distinguished Mentor Award.
Department News
Congratulations and best wishes to Michael Uhler, PhD, Professor Emeritus of Biological Chemistry and Research Professor Emeritus, Michigan Neuroscience Institute.
