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The Fundamentals
Treating Diabetes & Weight: The Ozempic & Wegovy Effect
Today on The Fundamentals, our guest Dr. Martin Myers, Director of the U-M Elizabeth Weiser Caswell Diabetes Institute, discusses diabetes research in the context of Ozempic, Wegovy, and other drugs that are changing how people think about weight loss. You can learn more about Dr. Myers here, and you can follow the department of molecular and integrative physiology @UMPhysiology on X.
Illustration of a microscope
Health Lab
Helpful enzymes vanish in many patients with antiphospholipid syndrome
Researchers recently revealed a new mechanism behind antiphospholipid syndrome that the investigators hope will eventually allow treatments to be targeted closer to the source of the problem.
Florescent image of a human ovarian follicle
Health Lab
Spatial atlas of the human ovary with cell-level resolution will bolster reproductive research
New map of the ovary provides a deeper understanding of how oocytes interact with the surrounding cells during the normal maturation process, and how the function of the follicles may break down in aging or fertility related diseases.
A CT scan of healthy lungs
Health Lab
Study reveals potential to reverse lung fibrosis using the body’s own healing technique
A recent U-M study uncovers a pathway utilized during normal wound healing that has the potential to reverse idiopathic pulmonary fibrosis.
White rat with pink eyes in a glass case
Health Lab
An updated rat reference provides more accuracy for research
An updated rat reference provides more accuracy for research; could help researchers using rat models for the study of DNA, RNA, evolution, or genes linked to disease risks
Close up image of red blood cells moving through veins
Health Lab
Discovery reveals how this common stinky gas is processed to promote blood vessel growth
A new collaborative study, examined the interaction between three naturally occurring gases — nitric oxide (NO), oxygen, and H2S — during generation of new blood vessels, called angiogenesis.
Illustration of hand and enzymes that affect scleroderma patients
Health Lab
Novel antibody targets CD38 enzyme to treat systemic sclerosis
New study has identified an enzyme contributing to systemic sclerosis.
Illustration of neuron cell
Health Lab
Two genes linked to autism implicated in brain cell connectivity
A new study links two autism-associated genes together for the first time, potentially revealing a mechanism behind brain changes seen in people with autism.
doctor with patient white and black patient ignored
Health Lab
Fixing racial inequities in lupus care
When it comes to lupus care, Black adults are normally left behind despite being one of the highest lupus populations.
Health Lab
Managing scleroderma symptoms through a team approach
Research published in the Arthritis Care and Research Journal from Michigan Medicine found that scleroderma patients made significant strides when working with trained peer health coaches in adhering to wellness routines, leading to resilience and improvements in fatigue, pain and depressive symptoms.
ginger bunch
Health Lab
Could ginger help treat autoimmune disease symptoms?
Michigan Medicine researchers are examining whether ginger supplements could help treat symptoms in autoimmune diseases
flies moving sled in snow with person
Health Lab
Gene links exercise endurance, cold tolerance and cellular maintenance in flies
A study in PNAS identifies a protein that, when missing, makes exercising in the cold that much harder—that is, at least in fruit flies.
stethoscope
Health Lab
Genetic mutation linked to adrenal tumor and hypertension
Research from the Department of Molecular & Integrative Physiology at Michigan Medicine identifies a previously unknown genetic mutation that causes the disease called primary aldosteronism in certain populations.
dna strand in blue grainy off white background yellow spots
Health Lab
A new regulator of innate immunity identified
One of the most important protein complexes in mammals involved in ERAD is called SEL1L-HRD1. Recent research finds that this protein complex helps regulate another critical protein involved in innate immunity, called STING, at the endoplasmic reticulum.
black room with person visual far away walking towards glowing light
Health Lab
Evidence of conscious-like activity in the dying brain
A Michigan Medicine study provides early evidence of a surge of activity correlated with consciousness in the dying brain.