Anthony Rosenzweig, MD
Stanley and Judith Frankel Professor of Heart and Brain Health
Professor of Internal Medicine
Professor of Pharmacology and Center Director
MM Institute for Heart and Brain Health
[email protected]

Available to mentor

Anthony Rosenzweig, MD
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Rosenzweig, MD graduated from Harvard College, where he majored in biochemistry and molecular biology. He received his medical degree from Harvard Medical School and completed his residency in internal medicine and fellowship in cardiovascular medicine at the Massachusetts General Hospital (MGH). Additional research training included a one-year predoctoral fellowship in neurosciences at the University of Pennsylvania and postdoctoral training in the laboratories of Drs. Jonathan and Christine Seidman, as well as Dr. Michael Gimbrone, all at Harvard Medical School.

    Dr. Rosenzweig is the inaugural Director of the Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) at the University of Michigan Medical Center. Previous leadership roles include having served as Chief of Cardiology, Co-Director of the Corrigan Minehan Heart Center and Director of Cardiovascular Research at MGH as well as the Paul Dudley White Professor of Medicine at Harvard Medical School (2015-2022). He also has served as the inaugural Director of the Program in Cardiovascular Gene Therapy at MGH, a Trustee of the Harvard Clinical Research Institute (an academic clinical research organization), an Executive Committee member of the Harvard Stem Cell Institute and its Cardiovascular Program Leader, as well as the Director of Cardiovascular Research and Associate Chief of Cardiology at the Beth Israel Deaconess Medical Center in Boston. Dr. Rosenzweig is also a member of the Leducq Foundation Scientific Advisory Committee and the American Heart Association Basic Sciences Council leadership.

    • Rosenzweig Lab
    • Residency in Internal Medicine
      Massachusetts General Hospital, Boston
    • Fellowship in Cardiovascular Medicine
      Massachusetts General Hospital, Boston
    • Postdoctoral Research Fellowship
      Harvard Medical School, Genetics
    • Postdoctoral Research Fellowship
      Brigham and Women's Hospital, Vascular Biology
    • M.D.
      Harvard Medical School, Boston
    Center Memberships
    • Center Member
      Biointerfaces Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Dr. Rosenzweig’s research has focused on identifying novel mechanisms and therapeutic targets in heart failure, using the exercised heart to understand what keeps hearts healthy. Of particular interest is how dysregulation of common pathways, such as those involved in metabolism, cellular senescence, or inflammation, can drive disease in multiple organs, including the brain and heart, since targeting such pathways could have broad clinical benefits. Dr. Rosenzweig is deeply committed to realizing the translational potential of basic science discoveries. His work has led to multiple patent awards, licensed approaches to mutation detection, and new therapeutic strategies being investigated in clinical trials. He has led successful partnerships with industry, served on industry advisory panels, and co-founded a recently funded biotech start-up focused on small molecule therapies for Long QT Syndrome. Dr. Rosenzweig has been a principal investigator for multiple successful research consortia including an international Leducq Foundation Network of Research Excellence, multiple NIH U-awards, an AHA Strategically Focused Research Network Center, and multiple NIH T32 training grants. His research has been continuously funded by the NIH for over 30 years.

    Recent Publications See All Publications
    • Journal Article
      Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
      Zureigat H, Osborne MT, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski AV, Wasfy MM, Guseh JS, Churchill TW, Rosovsky RP, Fayad Z, Rosenzweig A, Baggish A, Pitman RK, Choi KW, Smoller J, Shin LM, Tawakol A. Journal of the American College of Cardiology, 2024 Apr 23; 83 (16): 1543 - 1553. DOI:10.1016/j.jacc.2024.02.029
    • Journal Article
      Placental senescence pathophysiology is shared between peripartum cardiomyopathy and preeclampsia in mouse and human.
      Roh JD, Castro C, Yu A, Rana S, Shahul S, Gray KJ, Honigberg MC, Ricke-Hoch M, Iwamoto Y, Yeri A, Kitchen R, Guerra JB, Hobson R, Chaudhari V, Chang B, Sarma A, Lerchenmüller C, Al Sayed ZR, Diaz Verdugo C, Xia P, Skarbianskis N, Zeisel A, Bauersachs J, Kirkland JL, Karumanchi SA, Gorcsan J, Sugahara M, Damp J, Hanley-Yanez K, Ellinor PT, Arany Z, McNamara DM, IPAC Investigators , Hilfiker-Kleiner D, Rosenzweig A. Sci Transl Med, 2024 Apr 17; 16 (743): eadi0077 DOI:10.1126/scitranslmed.adi0077
      PMID: 38630848
    • Journal Article
      Intrinsic and Extrinsic Contributors to the Cardiac Benefits of Exercise
      Hastings MH, Castro C, Freeman R, Abdul Kadir A, Lerchenmüller C, Li H, Rhee J, Roh JD, Roh K, Singh AP, Wu C, Xia P, Zhou Q, Xiao J, Rosenzweig A. JACC: Basic to Translational Science, 2024 Apr 1; 9 (4): 535 - 552. DOI:10.1016/j.jacbts.2023.07.011
    • Journal Article
      Roles of Activin A and Gpnmb in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD).
      Liu H, Yerevanian A, Westerhoff M, Hastings MH, Guerra JRB, Zhao M, Svensson KJ, Cai B, Soukas AA, Rosenzweig A. Diabetes, 2024 Feb 1; 73 (2): 260 - 279. DOI:10.2337/db23-0357
      PMID: 37934943
    • Journal Article
      miR-222 inhibits pathological cardiac hypertrophy and heart failure.
      Liu X, Li H, Hastings MH, Xiao C, Damilano F, Platt C, Lerchenmüller C, Zhu H, Wei XP, Yeri A, Most P, Rosenzweig A. Cardiovasc Res, 2024 Mar 14; 120 (3): 262 - 272. DOI:10.1093/cvr/cvad184
      PMID: 38084908
    • Journal Article
      Abstract 16612: Cardiomyocyte PGC-1α Prevents Cardiac Atrophy and Failure in Response to Endurance Exercise Training
      Khetarpal S, LI H, Castro C, Houstis NA, Rhee J, Sprenger H-G, Mittenbuhler M, Kuznetsov A, Freeman R, Asnani A, Dumesic P, Roh JD, Rosenzweig A, Spiegelman B. Circulation, 2023 Nov 7; 148 (Suppl_1): a16612 - a16612. DOI:10.1161/circ.148.suppl_1.16612
    • Journal Article
      Cardioprotective and Anti-Inflammatory Effects of FAM3D in Myocardial Ischemia-Reperfusion Injury.
      Rhee J, Freeman R, Roh K, Lyons M, Xiao C, Zlotoff D, Yeri A, Li H, Guerra J, Guseh JS, Kuznetsov A, Houstis N, Roh J, Damilano F, Liu X, Silverman M, Kwong R, Das S, Rosenzweig A. Circ Res, 2023 Sep 15; 133 (7): 651 - 653. DOI:10.1161/CIRCRESAHA.123.322640
      PMID: 37638415
    • Journal Article
      Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction.
      Yurista SR, Eder RA, Welsh A, Jiang W, Chen S, Foster AN, Mauskapf A, Tang WHW, Hucker WJ, Coll-Font J, Rosenzweig A, Nguyen CT. Metabolism, 2023 Aug; 145: 155608 DOI:10.1016/j.metabol.2023.155608
      PMID: 37268056