![](https://medschool.umich.edu/sites/default/files/styles/square_1_1/public/2023-11/Peter_K_Todd_MD%2C_PhD.jpg?h=d94c4b90&itok=c7WFVR4w)
Available to mentor
![](https://medschool.umich.edu/sites/default/files/styles/square_1_1/public/2023-11/Peter_K_Todd_MD%2C_PhD.jpg?h=d94c4b90&itok=c7WFVR4w)
I am a physician scientist who studies inherited neurological disorders and a board-certified neurologist with specialty training in Movement Disorders and Neurogenetics. My lab studies nucleotide repeat expansion disorders, including work on Fragile X-associated disorders, C9orf72-associated ALS and Frontotemporal Dementia, Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS), Huntington's Disease and Myotonic Dystrophy. We use drosophila, mice and cell based (including human inducible pluripotent stem cells) model systems to explore the mechanisms underlying these diseases with a goal of developing novel therapeutics. We also explore novel means by which repetitive elements influence native neuronal function and contribute to common neurological conditions.
Clinically, I see patients with inherited neurodegenerative disorders, including Parkinson's Disease, Dementia, and Ataxia. I direct both the University of Michigan Fragile X Clinic and our Multidisciplinary Ataxia Clinic while also seeing patients and teaching residents and medical students at the Ann Arbor VA Medical Center. Administratively, I serve as Associate Chair for Research in the Department of Neurology at Michigan where I play active roles in faculty recruitment and retention, promotion, clinical trial infrastructure and help guide our department’s overall research strategy.
https://sites.google.com/site/toddlabmichigan/todd-lab
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Center MemberPrecision Health Initiative
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Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Bai J, Shahzad S, Nedumaran J, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier P, Ward M, Todd P, Barmada SJ. 2024 Jul 4;PreprintTDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms.
DOI:10.1101/2024.07.02.601776 PMID: 39005384 -
Tseng Y-J, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, Tank EMH, Jansen-West K, Kaufhold R, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK. Nucleic Acids Res, 2024 Jun 10; 52 (10): 5928 - 5949.Journal ArticleRibosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
DOI:10.1093/nar/gkae137 PMID: 38412259 -
2024 May;PresentationCGG Repeats as Functional Elements and Drivers of Disease
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Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Khurana V, Barmada SJ, Dijkstra AA, Todd PK. 2023 Dec 14;PreprintAAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons.
DOI:10.1101/2023.12.13.571345 PMID: 38168171 -
Glineburg MR, Yildirim E, Gomez N, Li X, Pak J, Altheim C, Waksmacki J, McInerney G, Barmada SJ, Todd PK. 2023 Nov 11;PreprintStress granule formation helps to mitigate neurodegeneration.
DOI:10.1101/2023.11.07.566060 PMID: 37986813 -
Tassone F, Protic D, Allen EG, Archibald AD, Baud A, Brown TW, Budimirovic DB, Cohen J, Dufour B, Eiges R, Elvassore N, Gabis LV, Grudzien SJ, Hall DA, Hessl D, Hogan A, Hunter JE, Jin P, Jiraanont P, Klusek J, Kooy RF, Kraan CM, Laterza C, Lee A, Lipworth K, Losh M, Loesch D, Lozano R, Mailick MR, Manolopoulos A, Martinez-Cerdeno V, McLennan Y, Miller RM, Montanaro FAM, Mosconi MW, Potter SN, Raspa M, Rivera SM, Shelly K, Todd PK, Tutak K, Wang JY, Wheeler A, Winarni TI, Zafarullah M, Hagerman RJ. Cells, 2023 Sep 21; 12 (18):Journal ArticleInsight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on FMR1 Premutation.
DOI:10.3390/cells12182330 PMID: 37759552 -
2023 Sep;PresentationRepeating Themes in Human Neurologic Disease
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Malik I, Tseng Y-J, Wieland CM, Green KM, Zheng K, Calleja K, Todd PK. Neurobiol Dis, 2023 Aug; 184: 106212Journal ArticleDissecting the roles of EIF4G homologs reveals DAP5 as a modifier of CGG repeat-associated toxicity in a Drosophila model of FXTAS.
DOI:10.1016/j.nbd.2023.106212 PMID: 37352983