Peter K Todd, MD, PhD
Chester and Anne Alecks Sackett Endowed Professor
Professor of Neurology
Associate Chair for Research
Department of Neurology
Medical Director
Neurology
Professor of Human Genetics
[email protected]

Available to mentor

Peter K Todd, MD, PhD
Professor
  • About
  • Links
  • Center Memberships
  • Recent Publications
  • About

    I am a physician scientist who studies inherited neurological disorders and a board-certified neurologist with specialty training in Movement Disorders and Neurogenetics. My lab studies nucleotide repeat expansion disorders, including work on Fragile X-associated disorders, C9orf72-associated ALS and Frontotemporal Dementia, Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS), Huntington's Disease and Myotonic Dystrophy. We use drosophila, mice and cell based (including human inducible pluripotent stem cells) model systems to explore the mechanisms underlying these diseases with a goal of developing novel therapeutics. We also explore novel means by which repetitive elements influence native neuronal function and contribute to common neurological conditions.

    Clinically, I see patients with inherited neurodegenerative disorders, including Parkinson's Disease, Dementia, and Ataxia. I direct both the University of Michigan Fragile X Clinic and our Multidisciplinary Ataxia Clinic while also seeing patients and teaching residents and medical students at the Ann Arbor VA Medical Center. Administratively, I serve as Associate Chair for Research in the Department of Neurology at Michigan where I play active roles in faculty recruitment and retention, promotion, clinical trial infrastructure and help guide our department’s overall research strategy.

    Links
    • https://sites.google.com/site/toddlabmichigan/todd-lab
    Center Memberships
    • Center Member
      Precision Health Initiative
    Recent Publications See All Publications
    • Journal Article
      Stress granule formation helps to mitigate neurodegeneration.
      Glineburg MR, Yildirim E, Gomez N, Rodriguez G, Pak J, Li X, Altheim C, Waksmacki J, McInerney GM, Barmada SJ, Todd PK. Nucleic Acids Res, 2024 Sep 9; 52 (16): 9745 - 9759. DOI:10.1093/nar/gkae655
      PMID: 39106168
    • Journal Article
      AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS neurons.
      Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Willey S, Van Deynze K, Mumm C, Boyle AP, Cortese A, Ndayisaba A, Khurana V, Barmada SJ, Dijkstra AA, Todd PK. Sci Adv, 2024 Sep 6; 10 (36): eadn2321 DOI:10.1126/sciadv.adn2321
      PMID: 39231235
    • Preprint
      TDP43 autoregulation gives rise to shortened isoforms that are tightly controlled by both transcriptional and post-translational mechanisms.
      Dykstra MM, Weskamp K, Gómez NB, Waksmacki J, Tank E, Glineburg MR, Snyder A, Pinarbasi E, Bekier M, Li X, Bai J, Shahzad S, Nedumaran J, Wieland C, Stewart C, Willey S, Grotewold N, McBride J, Moran JJ, Suryakumar AV, Lucas M, Tessier P, Ward M, Todd P, Barmada SJ. 2024 Jul 4; DOI:10.1101/2024.07.02.601776
      PMID: 39005384
    • Presentation
      Session: Molecular Mechanisms that Drive Cell Function and Fate
      Todd P. 2024 Jul 1;
    • Journal Article
      Ribosomal quality control factors inhibit repeat-associated non-AUG translation from GC-rich repeats.
      Tseng Y-J, Krans A, Malik I, Deng X, Yildirim E, Ovunc S, Tank EMH, Jansen-West K, Kaufhold R, Gomez NB, Sher R, Petrucelli L, Barmada SJ, Todd PK. Nucleic Acids Res, 2024 Jun 10; 52 (10): 5928 - 5949. DOI:10.1093/nar/gkae137
      PMID: 38412259
    • Presentation
      CGG Repeats as Functional Elements and Drivers of Disease
      2024 May;
    • Preprint
      AAGGG repeat expansions trigger RFC1-independent synaptic dysregulation in human CANVAS Neurons.
      Maltby CJ, Krans A, Grudzien SJ, Palacios Y, Muiños J, Suárez A, Asher M, Khurana V, Barmada SJ, Dijkstra AA, Todd PK. 2023 Dec 14; DOI:10.1101/2023.12.13.571345
      PMID: 38168171
    • Preprint
      Stress granule formation helps to mitigate neurodegeneration.
      Glineburg MR, Yildirim E, Gomez N, Li X, Pak J, Altheim C, Waksmacki J, McInerney G, Barmada SJ, Todd PK. 2023 Nov 11; DOI:10.1101/2023.11.07.566060
      PMID: 37986813