Joseph Wider, PhD
Research Assistant Professor
Emergency Medicine
[email protected]

Available to mentor
Joseph Wider, PhD
Research Assistant Professor
  • About
  • Recent Publications
    • About

    Dr. Wider’s lab studies the role of mitochondria in the brain. Mitochondria are central to normal brain function but are recognized as a common component in acute brain injuries, such as traumatic brain injury, ischemic stroke, cardiac arrest and neonatal hypoxic ischemic encephalopathy. Dr. Wider studies the molecular mechanisms of mitochondrial dysfunction and the causal relationship with the pathogenesis of injury. Using in vitro, preclinical and translational models, the Wider lab is focused on expanding our understanding of brain injury and developing therapies that improve neurological outcomes.

    Recent Publications See All Publications
    • Journal Article
      Mitochondrial membrane potential and oxidative stress interact to regulate Oma1-dependent processing of Opa1 and mitochondrial dynamics.
      Fogo GM, Raghunayakula S, Emaus KJ, Torres Torres FJ, Wider JM, Sanderson TH. FASEB J, 2024 Sep 30; 38 (18): e70066 DOI:10.1096/fj.202400313R
      PMID: 39312414
    • Journal Article
      Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest.
      Wider JM, Gruley E, Morse PT, Wan J, Lee I, Anzell AR, Fogo GM, Mathieu J, Hish G, O'Neil B, Neumar RW, Przyklenk K, Hüttemann M, Sanderson TH. Crit Care, 2023 Dec 14; 27 (1): 491 DOI:10.1186/s13054-023-04745-7
      PMID: 38098060
    • Journal Article
      Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides.
      Morse PT, Tuck S, Kerns M, Goebel DJ, Wan J, Waddell T, Wider JM, Hüttemann CL, Malek MH, Lee I, Sanderson TH, Hüttemann M. Bioeng Transl Med, 2023 May; 8 (3): e10496 DOI:10.1002/btm2.10496
      PMID: 37206207
    • Presentation
      Remote Preconditioning: Evaluating the Efficacy of Cardioprotection in Type-2 Diabetes and Exploring the Mechanistic Role of Exosomes
      2023 Jan 1;
    • Journal Article
      Parathyroid Hormone-Related Peptide and Its Analog, Abaloparatide, Attenuate Lethal Myocardial Ischemia-Reperfusion Injury.
      Wider J, Undyala VVR, Lanske B, Datta NS, Przyklenk K. J Clin Med, 2022 Apr 19; 11 (9): DOI:10.3390/jcm11092273
      PMID: 35566399
    • Journal Article
      Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest.
      Zhang R, Bryson TD, Fogo GM, Liao J, Raghunayakula S, Mathieu J, Wider JM, Ren X, Maheras KJ, Emaus KJ, Gruley E, Chen Y, Neumar RW, Sanderson TH. Mol Neurobiol, 2022 Mar; 59 (3): 1872 - 1881. DOI:10.1007/s12035-021-02645-x
      PMID: 35028899
    • Presentation
      Training through DCTP: Mitochondrial Basis of Neurological Injury
      2022 Jan 1;
    • Journal Article
      Machine learning-based classification of mitochondrial morphology in primary neurons and brain.
      Fogo GM, Anzell AR, Maheras KJ, Raghunayakula S, Wider JM, Emaus KJ, Bryson TD, Bukowski MJ, Neumar RW, Przyklenk K, Sanderson TH. Sci Rep, 2021 Mar 4; 11 (1): 5133 DOI:10.1038/s41598-021-84528-8
      PMID: 33664336