Joseph Wider, PhD
Research Assistant Professor
Emergency Medicine
Medical School
[email protected]

Available to mentor
Joseph Wider, PhD
Research Assistant Professor
  • About
  • Qualifications
  • Recent Publications
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    About

    Dr. Wider’s lab studies the role of mitochondria in the brain. Mitochondria are central to normal brain function but are recognized as a common component in acute brain injuries, such as traumatic brain injury, ischemic stroke, cardiac arrest and neonatal hypoxic ischemic encephalopathy. Dr. Wider studies the molecular mechanisms of mitochondrial dysfunction and the causal relationship with the pathogenesis of injury. Using in vitro, preclinical and translational models, the Wider lab is focused on expanding our understanding of brain injury and developing therapies that improve neurological outcomes.

    Qualifications
    • Research Fellow
      University of Michigan, Pleasant Ridge, 2021
    Recent Publications See All Publications
    • Journal Article
      Mitochondrial dynamics and quality control regulate proteostasis in neuronal ischemia-reperfusion
      Fogo GM, Raghunayakula S, Emaus KJ, Torres Torres FJ, Shangguan G, Wider JM, Hüttemann M, Sanderson TH. Autophagy, 2025 Jan 1; DOI:10.1080/15548627.2025.2472586
      PMID: 40016670
    • Journal Article
      Mitochondrial membrane potential and oxidative stress interact to regulate Oma1-dependent processing of Opa1 and mitochondrial dynamics
      Fogo GM, Raghunayakula S, Emaus KJ, Torres Torres FJ, Wider JM, Sanderson TH. FASEB Journal, 2024 Sep 30; 38 (18): DOI:10.1096/fj.202400313R
      PMID: 39312414
    • Journal Article
      Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest
      Wider JM, Gruley E, Morse PT, Wan J, Lee I, Anzell AR, Fogo GM, Mathieu J, Hish G, O’Neil B, Neumar RW, Przyklenk K, Hüttemann M, Sanderson TH. Critical Care, 2023 Dec 1; 27 (1): DOI:10.1186/s13054-023-04745-7
      PMID: 38098060
    • Journal Article
      Non-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides
      Morse PT, Tuck S, Kerns M, Goebel DJ, Wan J, Waddell T, Wider JM, Hüttemann CL, Malek MH, Lee I, Sanderson TH, Hüttemann M. Bioengineering and Translational Medicine, 2023 May 1; 8 (3): DOI:10.1002/btm2.10496
    • Presentation
      Remote Preconditioning: Evaluating the Efficacy of Cardioprotection in Type-2 Diabetes and Exploring the Mechanistic Role of Exosomes
      2023 Aug 17;
    • Journal Article
      Parathyroid Hormone-Related Peptide and Its Analog, Abaloparatide, Attenuate Lethal Myocardial Ischemia-Reperfusion Injury
      Wider J, Undyala VVR, Lanske B, Datta NS, Przyklenk K. Journal of Clinical Medicine, 2022 May 1; 11 (9): DOI:10.3390/jcm11092273
    • Journal Article
      Rapid Treatment with Intramuscular Magnesium Sulfate During Cardiopulmonary Resuscitation Does Not Provide Neuroprotection Following Cardiac Arrest
      Zhang R, Bryson TD, Fogo GM, Liao J, Raghunayakula S, Mathieu J, Wider JM, Ren X, Maheras KJ, Emaus KJ, Gruley E, Chen Y, Neumar RW, Sanderson TH. Molecular Neurobiology, 2022 Mar 1; 59 (3): 1872 - 1881. DOI:10.1007/s12035-021-02645-x
      PMID: 35028899
    • Presentation
      Training through DCTP: Mitochondrial Basis of Neurological Injury
      2023 Aug 17;
    Featured News & Stories 3D illustration of mitochondria
    Research News
    Weil Institute member lands $2.8 million grant to explore infrared light-based neuroprotective therapy
    Supported by NINDS, U-M investigators study the potential of infrared light to restore mitochondrial function and mitigate secondary brain injury.