Kevin S Chen, MD
Assistant Professor of Neurosurgery
Assistant Professor of Neurology
[email protected]

Available to mentor

Kevin S Chen, MD
Clinical Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Chen completed his Neurosurgical residency at Michigan Medicine, and additionally completed a fellowship in Stereotactic/Functional Neurosurgery at Stanford University. His clinical interests center on treating dysfunctional neural circuits, and using neuromodulation to help symptoms of movement disorders (e.g., Parkinson's disease, essential tremor, dystonia, etc.). Similarly, he has interest in neuromodulation using spinal cord stimulation for the treatment of certain chronic pain syndromes (e.g., complex regional pain syndrome, diabetic neuropathy, etc.), or use of intrathecal drug delivery (e.g., spasticity). He also has expertise in the surgical treatments of epilepsy, including vagal nerve stimulators, stereoelectroencephalography, responsive neurostimulators, deep brain stimulation for epilepsy, laser interstitial thermal therapy, and temporal lobectomy. During fellowship training, he also received training in the use of MRI-guided focused ultrasound, an incision-less approach for the treatment of movement disorders.

    • Clinical Fellowship
      Stanford Health Care, Neurosurgery, 2019
    • Residency
      Michigan Medicine, Neurosurgery, 2018
    • MD
      Duke University, DUMC 3878, 2011
    • BA
      Johns Hopkins University, Baltimore, 2007
    Center Memberships
    • Center Member
      Eisenberg Family Depression Center
    Research Overview

    Stem cells are a particular focus of Dr. Chen's research, specifically induced pluripotent stem cells (iPS). These cells are created from tissue that is easily obtainable from patients, for example, skin cells, and quickly grown in a culture dish. By genetically reprogramming these cells, they revert back to a “stem cell” state and can then be formed into nerve cells to form new brain connections. Dr. Chen is studying how these connections may impact ALS, Alzheimer's disease, and other dementias. The ability to regulate nerve activity with new nerve connections could eventually also be applied to other neurodegenerative disorders, such as Parkinson’s disease, as well as other conditions, such as epilepsy, stroke, chronic pain, and psychiatric diseases.

    Recent Publications See All Publications
    • Journal Article
      Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism.
      Chen KS, Noureldein MH, McGinley LM, Hayes JM, Rigan DM, Kwentus JF, Mason SN, Mendelson FE, Savelieffd MG, Feldman EL. bioRxiv, 2023 Nov 4; DOI:10.1101/2023.11.01.565161
      PMID: 37961246
    • Journal Article
      Regional interneuron transcriptional changes reveal pathologic markers of disease progression in a mouse model of Alzheimer's disease.
      Chen KS, Noureldein MH, Rigan DM, Hayes JM, Savelieff MG, Feldman EL. bioRxiv, 2023 Nov 4; DOI:10.1101/2023.11.01.565165
      PMID: 37961679
    • Journal Article
      Monoclonal antibody-mediated immunosuppression enables long-term survival of transplanted human neural stem cells in mouse brain.
      McGinley LM, Chen KS, Mason SN, Rigan DM, Kwentus JF, Hayes JM, Glass ED, Reynolds EL, Murphy GG, Feldman EL. Clin Transl Med, 2022 Sep; 12 (9): e1046 DOI:10.1002/ctm2.1046
      PMID: 36101963
    • Journal Article
      Magnetic resonance imaging of human neural stem cells in rodent and primate brain.
      McGinley LM, Willsey MS, Kashlan ON, Chen KS, Hayes JM, Bergin IL, Mason SN, Stebbins AW, Kwentus JF, Pacut C, Kollmer J, Sakowski SA, Bell CB, Chestek CA, Murphy GG, Patil PG, Feldman EL. Stem Cells Transl Med, 2021 Jan; 10 (1): 83 - 97. DOI:10.1002/sctm.20-0126
      PMID: 32841522
    • Journal Article
      Targeted intraspinal injections to assess therapies in rodent models of neurological disorders.
      Chen KS, McGinley LM, Kashlan ON, Hayes JM, Bruno ES, Chang JS, Mendelson FE, Tabbey MA, Johe K, Sakowski SA, Feldman EL. Nat Protoc, 2019 Feb; 14 (2): 331 - 349. DOI:10.1038/s41596-018-0095-5
      PMID: 30610242
    • Journal Article
      Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease.
      McGinley LM, Kashlan ON, Bruno ES, Chen KS, Hayes JM, Kashlan SR, Raykin J, Johe K, Murphy GG, Feldman EL. Sci Rep, 2018 Oct 3; 8 (1): 14776 DOI:10.1038/s41598-018-33017-6
      PMID: 30283042
    • Journal Article
      A simple, inexpensive method for subcortical stereotactic targeting in nonhuman primates.
      Bentley JN, Khalsa SSS, Kobylarek M, Schroeder KE, Chen K, Bergin IL, Tat DM, Chestek CA, Patil PG. J Neurosci Methods, 2018 Jul 15; 305: 89 - 97. DOI:10.1016/j.jneumeth.2018.05.007
      PMID: 29768185
    • Journal Article
      Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice.
      McGinley LM, Kashlan ON, Chen KS, Bruno ES, Hayes JM, Backus C, Feldman S, Kashlan BN, Johe K, Feldman EL. Ann Clin Transl Neurol, 2017 Oct; 4 (10): 749 - 755. DOI:10.1002/acn3.443
      PMID: 29046883