Assistant Professor of Biological Chemistry
[email protected]
Available to mentor
Chase A Weidmann
Assistant Professor
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Postdoctoral Scholar/Staff ScientistWashington University in St. Louis School of Medicine, Cell Biology and Physiology, 2021
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Postdoctoral FellowUniversity of North Carolina at Chapel Hill, Chemistry, 2020
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Ph.D. in Biological ChemistryUniversity of Michigan, Ann Arbor, MI, 2015
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B.S. in BiochemistryUniversity of Rochester, Rochester, NY, 2009
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
We are interested in how cellular signals are propagated through interactions between RNA and protein, and how these interaction networks malfunction during cancer and disease. While most of the human genome is transcribed into RNA, only a small portion (< 5%) encodes protein; the remainder of the transcriptome includes many classes of small and large noncoding RNAs whose mechanisms are not fully understood. Our vision is to leverage RNA and protein sequencing and imaging technologies to characterize RNA-protein interaction networks and generate novel therapeutic strategies that target protein interaction sites on RNA.
Website
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Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC. bioRxiv,PreprintFunctional Validation of SAM Riboswitch Element A from Listeria monocytogenes
DOI:10.1101/2024.05.28.596223 -
Hatfield BM, Weidmann CA, Weeks KM. Methods Mol Biol, 2024 2723: 143 - 159.Journal ArticleMeasuring Proximity-Mediated Function of mRNA Regulatory Proteins by Engineered Tethering.
DOI:10.1007/978-1-0716-3481-3_9 PMID: 37824069 -
Monroy-Eklund A, Taylor C, Weidmann CA, Burch C, Laederach A. RNA, 2023 May; 29 (5): 691 - 704.Journal ArticleStructural analysis of MALAT1 long noncoding RNA in cells and in evolution.
DOI:10.1261/rna.079388.122 PMID: 36792358 -
Mustoe AM, Weidmann CA, Weeks KM. Acc Chem Res, 2023 Apr 4; 56 (7): 763 - 775.Journal ArticleSingle-Molecule Correlated Chemical Probing: A Revolution in RNA Structure Analysis.
DOI:10.1021/acs.accounts.2c00782 PMID: 36917683 -
Grayeski PJ, Weidmann CA, Kumar J, Lackey L, Mustoe AM, Busan S, Laederach A, Weeks KM. Nucleic Acids Res, 2022 Sep 23; 50 (17): 9689 - 9704.Journal ArticleGlobal 5'-UTR RNA structure regulates translation of a SERPINA1 mRNA.
DOI:10.1093/nar/gkac739 PMID: 36107773 -
Olson SW, Turner A-MW, Arney JW, Saleem I, Weidmann CA, Margolis DM, Weeks KM, Mustoe AM. Mol Cell, 2022 May 5; 82 (9): 1708 - 1723.e10.Journal ArticleDiscovery of a large-scale, cell-state-responsive allosteric switch in the 7SK RNA using DANCE-MaP.
DOI:10.1016/j.molcel.2022.02.009 PMID: 35320755 -
Przanowska RK, Weidmann CA, Saha S, Cichewicz MA, Jensen KN, Przanowski P, Irving PS, Janes KA, Guertin MJ, Weeks KM, Dutta A. Cell Rep, 2022 Feb 15; 38 (7): 110361Journal ArticleDistinct MUNC lncRNA structural domains regulate transcription of different promyogenic factors.
DOI:10.1016/j.celrep.2022.110361 PMID: 35172143 -
Weidmann CA, Mustoe AM, Jariwala PB, Calabrese JM, Weeks KM. Nat Biotechnol, 2021 Mar; 39 (3): 347 - 356.Journal ArticleAnalysis of RNA-protein networks with RNP-MaP defines functional hubs on RNA.
DOI:10.1038/s41587-020-0709-7 PMID: 33077962
Department News
Assistant Professor Chase Weidmann of the Department of Biological Chemistry at U-M Medical School is the 2024 recipient of the Outstanding Faculty Mentor Award from the CMB Program.
