Assistant Professor of Biological Chemistry
[email protected]
Available to mentor
Chase A Weidmann
Assistant Professor
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Postdoctoral Scholar/Staff ScientistWashington University in St. Louis School of Medicine, Cell Biology and Physiology, 2021
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Postdoctoral FellowUniversity of North Carolina at Chapel Hill, Chemistry, 2020
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Ph.D. in Biological ChemistryUniversity of Michigan, Ann Arbor, MI, 2015
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B.S. in BiochemistryUniversity of Rochester, Rochester, NY, 2009
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
We are interested in how cellular signals are propagated through interactions between RNA and protein, and how these interaction networks malfunction during cancer and disease. While most of the human genome is transcribed into RNA, only a small portion (< 5%) encodes protein; the remainder of the transcriptome includes many classes of small and large noncoding RNAs whose mechanisms are not fully understood. Our vision is to leverage RNA and protein sequencing and imaging technologies to characterize RNA-protein interaction networks and generate novel therapeutic strategies that target protein interaction sites on RNA.
Website
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Hall I, O'Steen M, Gold S, C Keane S, Weidmann CA. RNA, 2024 Dec 16; 31 (1): 113 - 125.Journal ArticleTemplate switching enables chemical probing of native RNA structures.
DOI:10.1261/rna.079926.123 PMID: 39438135 -
Hao X, Chen Y, Sahu D, Przanowska RK, Weidmann CA, Nardi I, Weeks KM, Dutta A. 2024 Dec 24;PreprintA 36-base hairpin within lncRNA DRAIC , modulated by alternative splicing, interacts with the IKKα coiled-coil domain and inhibits NF-κB and tumor cell phenotypes.
DOI:10.1101/2024.12.23.629241 PMID: 39764029 -
Saleem I, Miller T, Kearns L, Mitchell D, Bose R, Weidmann CA, Mustoe AM. bioRxiv,PreprintSimultaneous mapping of RNA secondary, tertiary, and quaternary structure in living cells by multi-site DMS probing
DOI:10.1101/2024.11.27.625770 -
Connacher RP, Roden RT, Huang K-L, Korte AJ, Yeruva S, Dittbenner N, DesMarais AJ, Weidmann CA, Randall TA, Williams J, Hall TMT, Wagner EJ, Goldstrohm AC. Nucleic Acids Res, 2024 Nov 11; 52 (20): 12669 - 12688.Journal ArticleThe TRIM-NHL RNA-binding protein Brain Tumor coordinately regulates expression of the glycolytic pathway and vacuolar ATPase complex.
DOI:10.1093/nar/gkae810 PMID: 39351871 -
Weidmann C. 2024 Oct 24;PresentationChemically probing the landscape of RNA-protein networks inside of the cell
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Hall I, Zablock K, Sobetski R, Weidmann CA, Keane SC. Biochemistry, 2024 Oct 15; 63 (20): 2621 - 2631.Journal ArticleFunctional Validation of SAM Riboswitch Element A from Listeria monocytogenes.
DOI:10.1021/acs.biochem.4c00247 PMID: 39323220 -
Weidmann C. 2024 May 13;PresentationProbing RNA-protein networks inside of the cell
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Hatfield BM, Weidmann CA, Weeks KM. Methods Mol Biol, 2024 2723: 143 - 159.Journal ArticleMeasuring Proximity-Mediated Function of mRNA Regulatory Proteins by Engineered Tethering.
DOI:10.1007/978-1-0716-3481-3_9 PMID: 37824069
Department News
Assistant Professor Chase Weidmann of the Department of Biological Chemistry at U-M Medical School is the 2024 recipient of the Outstanding Faculty Mentor Award from the CMB Program.
