109 Zina Pitcher Place, A506
Ann Arbor, MI 48109-2200
Available to mentor
I am a Professor in the Radiology Department, with affiliated appointments in the Departments of Computational Medicine and Bioinformatics and Biomedical Engineering. I have over 16 years’ experience with medical imaging with an emphasis on quantitative imaging techniques and image processing and analysis for applications in oncology and pulmonology. Since 2011, I have focused my research on the development and analysis of surrogate imaging markers for phenotyping pulmonary diseases. One of my significant contributions to pulmonary imaging is the development of parametric response mapping (PRM), which simultaneously quantifies small airways disease and emphysema in patients with COPD. My groups algorithms, such as PRM, have been integrated into the study design of various US multi-center clinical trials, such as COPDGene and SPIROMICS. In addition, I have patented analytical techniques for improved phenotyping of lung disease, and I have played a critical role in the funding, through my SBIR, and development of a commercial PRM product as an FDA-approved medical imaging device. My group has also made advances in thoracic radiology through the development of a deep learning CNN model for detection and quantification of air trapping on CT scans from school-aged patients with cystic fibrosis
Lab website
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Research FellowNational Institutes of Health, Division of Bioengineering and Physical Science, 2006
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Research FellowUniversity Hospital of Essen, Department of Diagnostic and Interventional Radiology, 2005
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Postdoctoral FellowNational Institutes of Health, National Institute on Aging, 2002
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Center MemberCenter for Computational Medicine and Bioinformatics
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Center MemberRogel Cancer Center
Biomedical Imaging
Functional and Molecular Imaging
Image Analysis
Machine Learning
Computed Tomography
Magnetic Resonance Imaging/Spectroscopy
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Bell AJ, Pal R, Labaki WW, Hoff BA, Wang JM, Murray S, Kazerooni EA, Galban S, Lynch DA, Humphries SM, Martinez FJ, Hatt CR, Han MK, Ram S, Galban CJ. Respir Res, 2024 Feb 28; 25 (1): 106Journal ArticleLocal heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression.
DOI:10.1186/s12931-024-02729-x PMID: 38419014 -
Sharifi H, Bertini CD, Alkhunaizi M, Hernandez M, Musa Z, Borges C, Turk I, Bashoura L, Dickey BF, Cheng G-S, Yanik G, Galban CJ, Guo HH, Godoy MCB, Reinhardt JM, Hoffman EA, Castro M, Rondon G, Alousi AM, Champlin RE, Shpall EJ, Lu Y, Peterson S, Datta K, Nicolls MR, Hsu J, Sheshadri A. Blood Adv, 2024 Oct 8; 8 (19): 5156 - 5165.Journal ArticleCT strain metrics allow for earlier diagnosis of bronchiolitis obliterans syndrome after hematopoietic cell transplant.
DOI:10.1182/bloodadvances.2024013748 PMID: 39163616 -
Bell AJ, Ram S, Labaki WW, Murray S, Kazerooni EA, Galban S, Martinez FJ, Hatt CR, Wang JM, Ivanov V, McGettigan P, Khokhlovich E, Maiorino E, Suryadevara R, Boueiz A, Castaldi P, Mirkes EM, Zinovyev A, Gorban AN, Galban CJ, Han MK. Am J Respir Crit Care Med, 2024 Sep 13;Journal ArticleTemporal Exploration of COPD Phenotypes: Insights from the COPDGene and SPIROMICS Cohorts.
DOI:10.1164/rccm.202401-0127OC PMID: 39269427 -
Chaudhary MFA, Awan HA, Gerard SE, Bodduluri S, Comellas AP, Barjaktarevic IZ, Graham Barr R, Cooper CB, Galban CJ, Han MK, Curtis JL, Hansel NN, Krishnan JA, Menchaca MG, Martinez FJ, Ohar J, Vargas Buonfiglio LG, Paine R, Bhatt SP, Hoffman EA, Reinhardt JM. 2024 Sep 11;PreprintDeep Learning Estimation of Small Airways Disease from Inspiratory Chest CT is Associated with FEV1 Decline in COPD.
DOI:10.1101/2024.09.10.24313079 PMID: 39314974 -
Bayfield KJ, Weinheimer O, Middleton A, Boyton C, Fitzpatrick R, Kennedy B, Blaxland A, Jayasuriya G, Caplain N, Wielpütz MO, Yu L, Galban CJ, Robinson TE, Bartholmai B, Gustafsson P, Fitzgerald D, Selvadurai H, Robinson PD. J Cyst Fibros, 2024 Sep; 23 (5): 918 - 925.Journal ArticleComparative sensitivity of early cystic fibrosis lung disease detection tools in school aged children.
DOI:10.1016/j.jcf.2024.05.012 PMID: 38969602 -
Combs MP, Belloli EA, Gargurevich N, Flaherty KR, Murray S, Galbán CJ, Lama VN. J Heart Lung Transplant, 2024 Sep; 43 (9): 1468 - 1477.Journal ArticleResults from randomized trial of pirfenidone in patients with chronic rejection (STOP-CLAD study).
DOI:10.1016/j.healun.2024.05.013 PMID: 38796045 -
Opron K, Begley LA, Erb-Downward JR, Li G, Alexis NE, Barjaktarevic I, Barr RG, Bleecker ER, Boucher R, Bowler RP, Christenson SA, Comellas AP, Criner G, Cooper CB, Couper D, Galban CJ, Han MK, Hastie A, Hatt C, Hoffman EA, Kaner RJ, Kesimer M, Krishnan JA, LaFon DC, Martinez FJ, Ortega VE, Peters SP, Paine R, Putcha N, Woodruff PG, Huffnagle GB, Kozik AJ, Curtis JL, Huang YJ, SPIROMICS Investigators . Am J Respir Crit Care Med, 2024 Jul 15; 210 (2): 186 - 200.Journal ArticleLoss of Airway Phylogenetic Diversity Is Associated with Clinical and Pathobiological Markers of Disease Development in Chronic Obstructive Pulmonary Disease.
DOI:10.1164/rccm.202303-0489OC PMID: 38261629 -
Gerard SE, Dougherty TM, Nagpal P, Jin D, Han MK, Newell JD, Saha PK, Comellas AP, Cooper CB, Couper D, Fortis S, Guo J, Hansel NN, Kanner RE, Kazeroni EA, Martinez FJ, Motahari A, Paine R, Rennard S, Schroeder JD, Woodruff PG, Barr RG, Smith BM, Hoffman EA, SPIROMICS Research Group . Ann Am Thorac Soc, 2024 Jul; 21 (7): 1022 - 1033.Journal ArticleVessel and Airway Characteristics in One-Year Computed Tomography-defined Rapid Emphysema Progression: SPIROMICS.
DOI:10.1513/AnnalsATS.202304-383OC PMID: 38530051
