Jack M Parent

 profile-jack-parent-2014
William J Herdman Professor of Neurology
Professor of Neurology and Research Professor
Michigan Neuroscience Institute
Medical School
[email protected]
Available to mentor
Jack M Parent
profile-jack-parent-2014
Professor
  • Qualifications
  • Center Memberships
  • Recent Publications

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    • Qualifications
    • Postdoctoral Fellow, Epilepsy Research Laboratory
      University of California, San Francisco, San Francisco, United States
      1996 - 2000
      Postdoctoral Fellowship
    • Fellow in Epilepsy and Clinical Neurophysiology, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1994 - 1996
      Postdoctoral Fellowship
    • Chief Resident, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1993 - 1994
      Chief Resident
    • Resident, Department of Neurology
      University of California, San Francisco, San Francisco, United States
      1991 - 1993
      Residency
    • Intern, Department of Internal Medicine
      University of California, San Francisco, San Francisco, United States
      1990 - 1991
      Internship
    • MD
      Yale University School of Medicine, New Haven, CT, United States
      1986 - 1990
    • AB
      Stanford University, Stanford, CA, United States
      1982 - 1986

    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Taubman Institute

    Recent Publications

     See All Publications
    • Journal Article
      Cardiac remodeling and arrhythmia in a mouse model of Depdc5 haploinsufficiency
      Ramos-Mondragon R, Wang S, Liu Q, Chen C, Greiner AM, Marx AM, Shih M, Parent JM, London B, Isom LL. Epilepsia, 2026 Jan 1; DOI:10.1002/epi.70244
    • Journal Article
      Non-Synaptic Function and Localization of Syntaxin-Binding Protein 1 in a Mouse Model of STXBP1-Related Epileptic Encephalopathy
      Yang T, Banerjee R, Deng Y, Jahagirdar1 S, Nesvizhskii AI, Uhler MD, Parent JM, Wang Y. Annals of Neurology, 2026 Jan 1; DOI:10.1002/ana.78097
      PMID: 41510908
    • Preprint
      Hyperthermic Seizure Susceptibility and Focal Decreases in Parvalbumin-Expressing Cortical Interneurons in a Mouse Model of PCDH19-Clustering Epilepsy
      Ziobro J, Huang J, Daddo N, Margolis E, Jonatzke K, Umemori H, Parent JM. 2025 Nov 14; Cold Spring Harbor Laboratory, DOI:10.1101/2025.11.12.688097
    • Journal Article
      Cortical Versus Hippocampal Network Dysfunction in a Human Brain Assembloid Model of Epilepsy and Intellectual Disability
      McCrimmon C, Toker D, Pahos M, Cao Q, Lozano K, Lin J, Parent J, Tidball A, Zheng J, Molnar L, Mody I, Novitch B, Samarasinghe R. Cell reports, 2025 Aug 8;
    • Journal Article
      Altered Cardiac Excitability and Arrhythmia in Models of SCN1B-Linked Developmental and Epileptic Encephalopathy.
      Ramos-Mondragon R, Wang S, Edokobi N, Liu Q, Qiao X, Shih M, Dang LT, Tsan Y-C, Štěrbová K, Helms AS, Weckhuysen S, Lopez-Santiago LF, Parent JM, Isom LL. JCI Insight, 2025 Aug 5; DOI:10.1172/jci.insight.190918
      PMID: 40763036
    • Journal Article
      Health priorities and treatment preferences of adults with epilepsy: A narrative literature review with a systematic search
      Hill CE, Vanderboll K, Parent JM, Skolarus LE, Zahuranec DB. Epilepsy and Behavior, 2025 May 1; 166: DOI:10.1016/j.yebeh.2025.110359
    • Preprint
      EpiPred: A gene-specific machine learning model for classifying missense variants in the epilepsy-related gene <i>STXBP1</i>
      Calhoun J, Wang C, Biar C, Gunti J, Lee J, Geller A, Hong J, Schnell S, Dang L, Wang Y, Parent J, Isom L, Uhler M, Mefford H, Ross E, Aguiar-Pulido V, Carvill G. 2025 Oct 23; bioRxiv, DOI:10.1101/2025.08.09.669488
    • Proceeding / Abstract / Poster
      Dravet Syndrome Patient Variant SCN1B p.R89C Alters Neuronal Membrane Electric Properties Leading to Hyperexcitability in Human iPSC-derived Excitatory Cortical Neurons.
      Yuan Y, Lopez-Santiago L, Dang L, Lin G, Swaminathan P, Vaid S, Loughman A, Tidball A, Štěrbová K, Weckhuysen S, DeJonghe P, Parent J, Isom L. 2024 Dec 6;

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