David S Lorberbaum
Assistant Professor of Pharmacology
Medical School
6313 Brehm Tower
Department of Pharmacology
1000 Wall Street
Ann Arbor, MI 48105
[email protected]
Department of Pharmacology
1000 Wall Street
Ann Arbor, MI 48105
Available to mentor
David S Lorberbaum
Assistant Professor
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About
The pancreas is a multifunctional organ and is susceptible to a myriad of diseases. We use a combination of in vivo mouse genetics, in vitro human-derived embryonic stem cell differentiations, and ex vivo pancreatic organoid cultures to define the mechanisms by which the pancreas develops, matures, and functions in health and disease with the ultimate goal of improving therapeutic treatments for pancreas disorders, like diabetes and agenesis.
Links
Laboratory Website
Qualifications
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Postdoctoral FellowUniversity of Colorado Denver Anschutz Medical Campus, Barbara Davis Center for Diabetes, Aurora, United States
2016 - 2023
Postdoctoral Fellowship
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PhDUniversity of Michigan, Ann Arbor, United States
2010 - 2016
Center Memberships
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
Research Overview
Cell signaling, gene regulation, transcription factors, context-specific gene expression, development, cell biology, diabetes, pancreas agenesis, stem cell derived islets, organoids, mouse genetics, disease models
Recent Publications
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Como CN, O'Rourke R, Winkler C, Mitchell D, Tran L, Lorberbaum D, Sussel L, Franco S, Siegenthaler J. Cell Reports, 2025 May 27; 44 (5):Journal ArticleMeningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
DOI:10.1016/j.celrep.2025.115637 PMID: 40310723 -
Bandral M, Sussel L, Lorberbaum DS. Current Topics in Developmental Biology, 2025 Jan 1; 161: 297 - 318.ChapterRetinoid signaling in pancreas development, islet function, and disease
DOI:10.1016/bs.ctdb.2024.10.007 PMID: 39870436 -
Como CN, O’Rourke R, Winkler C, Mitchell D, Tran L, Lorberbaum D, Sussel L, Franco S, Siegenthaler J. 2024 Apr 11; bioRxiv,PreprintMeningeal-derived retinoic acid regulates neurogenesis via suppression of Notch and Sox2
DOI:10.1101/2024.04.05.588348 -
Lorberbaum DS, Sarbaugh D, Sussel L. Frontiers in Endocrinology, 2022 Oct 21; 13:Journal ArticleLeveraging the strengths of mice, human stem cells, and organoids to model pancreas development and diabetes
DOI:10.3389/fendo.2022.1042611 -
Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Stem Cell Reports, 2021 Apr 13; 16 (4): 1009Journal ArticleErratum: Modeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System (Stem Cell Reports (2020) 14(6) (1033–1043), (S2213671120301430), (10.1016/j.stemcr.2020.04.003))
DOI:10.1016/j.stemcr.2021.03.006 PMID: 33852882 -
Ramirez DG, Abenojar E, Hernandez C, Lorberbaum DS, Papazian LA, Passman S, Pham V, Exner AA, Benninger RKP. Nature Communications, 2020 Dec 1; 11 (1):Journal ArticleContrast-enhanced ultrasound with sub-micron sized contrast agents detects insulitis in mouse models of type1 diabetes
DOI:10.1038/s41467-020-15957-8 PMID: 32382089 -
Lorberbaum DS, Kishore S, Rosselot C, Sarbaugh D, Brooks EP, Aragon E, Xuan S, Simon O, Ghosh D, Mendelsohn C, Gadue P, Sussel L. Development Cambridge, 2020 Jun 22; 147 (12):Journal ArticleRetinoic acid signaling within pancreatic endocrine progenitors regulates mouse and human β cell specification
DOI:10.1242/dev.189977 PMID: 32467243 -
Hudish LI, Bubak A, Triolo TM, Niemeyer CS, Lorberbaum DS, Sussel L, Nagel M, Taliaferro JM, Russ HA. Stem Cell Reports, 2020 Jun 9; 14 (6): 1033 - 1043.Journal ArticleModeling Hypoxia-Induced Neuropathies Using a Fast and Scalable Human Motor Neuron Differentiation System.
DOI:10.1016/j.stemcr.2020.04.003 PMID: PMC7355142
