Shyamal Mosalaganti, PhD
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About
Shyamal Mosalaganti was born and brought up in India. He earned his bachelor's and master's degrees in chemistry from the Sri Sathya Sai Institute of Higher learning, India. He then moved to the Max Planck Institute of Molecular Physiology in Dortmund, Germany, on an International Max Planck Research Fellowship to study the structure and function of membrane proteins in the lab of Stefan Raunser. During his Ph.D. program, he also worked in collaboration with the group of Andrea Musacchio to elucidate the architecture of the components of human kinetochore.
Inspired by the revolution in cryo-electron microscopy, Mosalaganti continued his postdoctoral research work in understanding the architecture of protein complexes in near-native environments (in-situ structural biology). In the lab of Martin Beck at the European Molecular Biology Laboratory, his work led to mapping the symmetric core of the human nuclear pore complex.
In his lab at the U-M Life Sciences Institute, Mosalaganti continues to provide structural snapshots of macromolecular complexes in-situ, with a special focus on understanding lysosomal function, positioning and inter-organelle crosstalk.
Qualifications
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Postdoctoral FellowEuropean Molecular Biology Laboratory, Structural and Computational Biology Unit, Heidelberg, Germany
2015 - 2020
Postdoctoral Fellowship
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Postdoctoral FellowMax Planck Institute of Molecular Physiology, Department of Structural Biochemistry, Dortmund, Germany
2014 - 2015
Postdoctoral Fellowship
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Project AssociateIndian Institute of Science, Department of Biochemistry, Bangalore, India
2007 - 2009
Postdoctoral Fellowship
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Ph.D. in BichemistryMax Planck Institute of Molecular Physiology, Dortmund, Germany
2009 - 2014
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M.Sc. in ChemistrySri Satya Sai Institute of Higher Learning, Puttaparthi, India
2005 - 2007
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B.Sc. ChemistrySri Satya Sai Institute of Higher Learning, Bengaluru, India
2002 - 2005
Research Overview
My laboratory is interested in understanding how membrane-enclosed structures within our cells perform their jobs to maintain cell health. We are particularly interested in lysosomes, which not only play an important role in cellular 'waste management,' but also serve as a key decision-making center controlling cellular growth and survival. My lab combines state-of-the-art cryo-electron microscopy/tomography and correlative microscopy approaches with biochemical and cell biology methods to elucidate how lysosomes perform their functions and engage in clearance of pathological aggregates, transport ions and metabolites and play indispensible roles in maintaining cellular homeostasis.
Recent Publications
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Rana JK, Pinarbasi ES, Fernandez MG, Navratna V, Conway KS, Lieberman AP, Barmada SJ, Mosalaganti S. Acta Neuropathologica, 2026 Dec 1; 152 (1):Journal ArticleCTE-type tau filaments in Alzheimer’s disease with co-morbid LATE-NC
DOI:10.1007/s00401-026-03052-z PMID: 42410250 -
Ma Q, Hernandez CC, Navratna V, Kumar A, Rana JK, Zong J, Lee A, Mosalaganti S. Nature Communications, 2026 Dec 1; 17 (1):Journal ArticleInsights into the structure and modulation of human TWIK-2
DOI:10.1038/s41467-026-69072-1 PMID: 41617707 -
Mosalaganti S. 2026 Jul 8;PresentationLysosomes at the Crossroads of Neurodegeneration
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Mosalaganti S. 2026 Jul 8;PresentationLysosomes at the Crossroads of Neurodegeneration
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Replogle JM, Marks JD, Fernandez MG, Yuan H, Yu D, Winters E, Jawahar VM, Deshmukh R, Sutanto R, Kowal I, Frankenfield A, Shi R, Carlomagno Y, Jansen-West K, Todd TW, Kopach A, Sandra Ndayambaje I, Qi YA, Shantaraman A, Pozo-Cabanell I, Sheth U, Yue M, Duong D, Ferguson SM, Bennett DA, Damme M, Boeve BF, Day GS, Kellman B, Skarnes WC, Petersen RC, Josephs KA, Graff-Radford NR, McDonough JA, Prudencio M, Barmada SJ, Zhang Y, Hao L, DeTure M, Rawlinson B, Engelberg-Cook E, Casey MC, Perez N, Dickson DW, Wingo A, Liu Y, Seyfried NT, Wingo TS, Mosalaganti S, Petrucelli L, Ward ME. 2026 Mar 28;PreprintNeurodegeneration risk variants promote lysosomal TMEM106B fibril accumulation.
DOI:10.64898/2026.03.26.714634 PMID: 41929000 -
Chen B, Stark DC, Jadhav PV, Lynn-Nguyen TM, Halligan BS, Rossiter NJ, Sindoni N, Shin M, Paulo JA, Chang M, Koo I, Koshkin S, Eyunni S, Ronchi P, Paulsen MT, Greenbaum HS, Ruckert MT, Morlacchi P, Hanna DA, Lin J, Guerra RM, Liu T, Pagliarini DJ, Banerjee R, Parolia A, Ljungman ME, Patterson AD, Mancias JD, Mosalaganti S, Sexton JZ, Calì T, Lyssiotis CA, Shah YM. Molecular Cell, 2026 Mar 5; 86 (5): 917 - 936.e12.Journal ArticleBRD4-mediated ER membrane contact creates functionally distinct mitochondrial subtypes
DOI:10.1016/j.molcel.2026.01.012 PMID: 41690300 -
Mosalaganti S. 2026 May 28;PresentationLysosomes in Health and Disease
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Connelly SM, Bergner L, Tiwari A, Brant TS, Medford S, Ramesh S, Tidwell ED, Yoo Y, Xiao K, Gentry J, Chang L, Han B, Rangamani P, Doktorova M, Kenworthy AK, Mosalaganti S, Ohi MD. 2026 Feb 17;PreprintStructural basis of caveolin-driven membrane bending.
DOI:10.64898/2026.02.05.703862 PMID: 41717096
Featured News & Stories
New Publication led by Dr. Subhash Arya (Parent Lab) in close collaboration with the Coulombe and Mosalaganti Labs!
