Available to mentor
John Varga MD attended Columbia University in New York, and obtained his medical degree from New York University. He completed Internal Medicine Residency at Rhode Island Hospital in Providence and Rheumatology Fellowship at Boston University. Following post-doctoral research at the University of Pennsylvania, he was on the faculty of the University of Illinois and Northwestern University in Chicago, and recently was recruited to Chief of Rheumatology at the University of Michigan. For the past three decades, Varga’s research has focused on fibrosis and the application of precision medicine approaches to improve patient outcomes. His lab, continuously funded by the NIH, investigates immunological and cellular mechanisms of fibrosis. He has served as a charter member of the NIH ACTS Study section and Co-Editor of Arthritis and Rheumatology, and is a member of the ACR Board of Directors. He is the author of more than 380 journal articles and book chapters and three textbooks. He has mentored over 20 post-doctoral MD and PhD trainees, many of whom have gone on to develop successful academic or industry careers.
John Varga Sclerolab
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Post-doctoral Research Fellow, T32University of Pennsylvania, Philadelphia, 1987
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Rheumatology FellowBoston University School of Medicine, Boston, 1985
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Intern and Resident in MedicineRhode Island Hospital/Brown, United States, 1983
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MDNew York University School of Medicine, New York, 1980
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BAColumbia University, New York, 1975
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Center MemberCenter for Computational Medicine and Bioinformatics
My lab studies inflammation and metabolism in the context of chronic autoimmune and fibrotic diseases. We use mouse models, patient samples, genetics and genomics to identify mechanisms of disease and novel targets for therapy. Our research is patient-oriented and we embrace of a tight "bench-to-bedside-to bench" approach. Our Michigan Scleroderma Program afford unique access to patients including genetics and biological specimen, for our research, including early-stage clinical trials.
Visit the John Varga Sclerolab website: https://medresearch.umich.edu/labs-departments/labs/sclerolab
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Kortam N, Liang W, Shiple C, Huang S, Gedert R, Clair JS, Sarosh C, Foster C, Tsou P-S, Varga J, Knight JS, Khanna D, Ali RA. Arthritis Res Ther, 2024 Jul 25; 26 (1): 139Journal ArticleElevated neutrophil extracellular traps in systemic sclerosis-associated vasculopathy and suppression by a synthetic prostacyclin analog.
DOI:10.1186/s13075-024-03379-6 PMID: 39054558 -
Dal Santo T, Golberg M, Nassar E-L, Carrier M-E, Hu S, Kwakkenbos L, Bartlett SJ, Fox RS, Lee YC, Varga J, Benedetti A, Thombs BD, Scleroderma Patient-centered Intervention Network Pain Patient Advisory Team . BMC Rheumatol, 2024 Jun 21; 8 (1): 28Journal ArticleProtocol for the development of a tool to map systemic sclerosis pain sources, patterns, and management experiences: a Scleroderma Patient-centered Intervention Network patient-researcher partnership.
DOI:10.1186/s41927-024-00398-3 PMID: 38907303 -
Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210Journal ArticleSystems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
DOI:10.1038/s41467-023-44645-6 PMID: 38172207 -
Jang JW, Capaldi E, Smith T, Verma P, Varga J, Ho KJ. Mol Med, 2024 Aug 23; 30 (1): 128Journal ArticleTrimethylamine N-oxide: a meta-organismal axis linking the gut and fibrosis.
DOI:10.1186/s10020-024-00895-8 PMID: 39180015 -
Adams C, Nassar E-L, Carrier M-E, Kwakkenbos L, Henry RS, Virgili-Gervais G, Hu S, Bartlett SJ, Fortuné C, Gietzen A, Gottesman K, Guillot G, Hudson M, Lawrie-Jones A, Lewis N, Malcarne V, Mayes MD, Patten SB, Richard M, Sauvé M, Varga J, Welling J, Wojeck R, Mouthon L, Benedetti A, Thombs BD, SPIN Investigators . J Scleroderma Relat Disord, 2024 Oct; 9 (3): 242 - 247.Journal ArticleChanges in work and adequacy of financial resources during COVID-19 among people with systemic sclerosis: A Scleroderma Patient-centered Intervention Network study.
DOI:10.1177/23971983241262655 PMID: 39381050 -
Nassar E-L, Virgili-Gervais G, Carrier M-E, Kwakkenbos L, Henry RS, Hu S, Provencher S, Golberg M, Bartlett SJ, Mouthon L, Patten SB, Varga J, Benedetti A, Thombs BD, Scleroderma Patient-centered Intervention Network (SPIN) COVID-19 Patient Advisory Team, on behalf of the SPIN Investigators . Lancet Rheumatol, 2024 Oct; 6 (10): e660 - e663.Journal ArticleExperiences of telehealth during and after the COVID-19 pandemic and preferences for future care of people with systemic sclerosis: a cross-sectional study.
DOI:10.1016/S2665-9913(24)00166-8 PMID: 38944052 -
Virgili-Gervais G, Henry RS, Kwakkenbos L, Carrier M-E, Patten S, Bartlett SJ, Mouthon L, Varga J, Benedetti A, Thombs BD, SPIN COVID-19 Patient Advisory Team , SPIN Investigators . J Psychosom Res, 2024 Sep; 184: 111852Journal ArticleAssociation of COVID-19 vaccination and anxiety symptoms: A Scleroderma Patient-centered Intervention Network (SPIN) Cohort longitudinal study.
DOI:10.1016/j.jpsychores.2024.111852 PMID: 38936011 -
Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. Arthritis Care Res (Hoboken), 2024 Aug; 76 (8): 1070 - 1082.Journal Article2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases.
DOI:10.1002/acr.25347 PMID: 38973729
