Warner-Lambert/Parke-Davis Professor of Medicine
Professor of Pharmacology and Associate Chair for Innovation and Wellness
Department of Pharmacology
[email protected]
Available to mentor
Yoichi Osawa
Professor
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Sun Y, Martinez-Ramos C, Chen E, Osawa Y, Zhang H. Biomedicines, 2024 Aug 15; 12 (8):Journal ArticleA General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library.
DOI:10.3390/biomedicines12081863 PMID: 39200327 -
Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464Journal ArticleMapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
DOI:10.1016/j.jbc.2023.105464 PMID: 37979917 -
Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. J Biol Chem, 2023 Aug; 299 (8): 105050Journal ArticleComputational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign.
DOI:10.1016/j.jbc.2023.105050 PMID: 37451479 -
Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Molecules, 2023 Jul 12; 28 (14):Journal ArticleThe Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.
DOI:10.3390/molecules28145353 PMID: 37513226 -
Morishima Y, Lau M, Pratt WB, Osawa Y. J Biol Chem, 2023 Feb; 299 (2): 102856Journal ArticleDynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
DOI:10.1016/j.jbc.2022.102856 PMID: 36596358 -
Cheng S, Bo Z, Hollenberg P, Osawa Y, Zhang H. J Biol Chem, 2021 296: 100645Journal ArticleAmphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase.
DOI:10.1016/j.jbc.2021.100645 PMID: 33839156 -
Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Biophys Chem, 2021 Jul; 274: 106590Journal ArticleMapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
DOI:10.1016/j.bpc.2021.106590 PMID: 33894563 -
Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Thomas DG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Clin Cancer Res, 2020 Oct 1; 26 (19): 5246 - 5257.Journal ArticleLow-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.
DOI:10.1158/1078-0432.CCR-19-3102 PMID: 32718999
