Yoichi Osawa
Warner-Lambert/Parke-Davis Professor of Medicine
Associate Chair, Department of Pharmacology
Professor of Pharmacology
[email protected]

Available to mentor

Yoichi Osawa
  • Recent Publications
  • Recent Publications See All Publications
    • Journal Article
      Mapping interactions of calmodulin and neuronal NO synthase by crosslinking and mass spectrometry.
      Felker D, Lee K, Pospiech TH, Morishima Y, Zhang H, Lau M, Southworth DR, Osawa Y. J Biol Chem, 2024 Jan; 300 (1): 105464 DOI:10.1016/j.jbc.2023.105464
      PMID: 37979917
    • Journal Article
      Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign.
      Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. J Biol Chem, 2023 Aug; 299 (8): 105050 DOI:10.1016/j.jbc.2023.105050
      PMID: 37451479
    • Journal Article
      The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.
      Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Molecules, 2023 Jul 12; 28 (14): DOI:10.3390/molecules28145353
      PMID: 37513226
    • Journal Article
      Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase.
      Morishima Y, Lau M, Pratt WB, Osawa Y. J Biol Chem, 2023 Feb; 299 (2): 102856 DOI:10.1016/j.jbc.2022.102856
      PMID: 36596358
    • Journal Article
      Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase.
      Cheng S, Bo Z, Hollenberg P, Osawa Y, Zhang H. J Biol Chem, 2021 296: 100645 DOI:10.1016/j.jbc.2021.100645
      PMID: 33839156
    • Journal Article
      Mapping protein-protein interactions in homodimeric CYP102A1 by crosslinking and mass spectrometry.
      Felker D, Zhang H, Bo Z, Lau M, Morishima Y, Schnell S, Osawa Y. Biophys Chem, 2021 Jul; 274: 106590 DOI:10.1016/j.bpc.2021.106590
      PMID: 33894563
    • Journal Article
      Hsp70:CHIP Ubiquitinates Dysfunctional but Not Native Neuronal NO Synthase.
      Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Mol Pharmacol, 2020 Sep; 98 (3): 243 - 249. DOI:10.1124/mol.120.119990
      PMID: 32591478
    • Presentation
      Hsp90- and Hsp70- based Chaperone Machinery as a Heme Insertase
      2018 Oct 1;