Available to mentor
My research focuses on identifying the genetic and genomic components for psoriasis, and understanding their biological effect and contribution to disease heterogeneity. I currently direct the Center for Cutaneous Bioinformatics at the University of Michigan, and I am the associate director of the Functional Analytic Core of the P30-funded University of Michigan Skin Biology Disease and Resource Center.
I have been actively involved in coordinating and conducting different genetic and genomic studies to understand the pathophysiology of different immune-mediated disorders including psoriasis, psoriatic arthritis, atopic dermatitis, and cutaneous lupus. By using systems biology approaches, we have revealed robust disease associated signals and candidates for downstream functional assays of psoriasis and facilitated the identification of genetic signature for psoriatic arthritis risk. My research also focuses on the development and implementation of computational pipeline for genomic data to identify novel disease-associated transcripts as well as context-specific inflammatory responses for inflammatory disorders.
-
Research FellowUniversity of Michigan, Biostatistics
-
Center MemberPrecision Health Initiative
-
Petrova E, López-Gay JM, Fahrner M, Leturcq F, de Villartay J-P, Barbieux C, Gonschorek P, Tsoi LC, Gudjonsson JE, Schilling O, Hovnanian A. Commun Biol, 2024 Feb 5; 7 (1): 152Journal ArticleComparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.
DOI:10.1038/s42003-024-05780-y PMID: 38316920 -
Petrova E, López-Gay JM, Fahrner M, Leturcq F, de Villartay J-P, Barbieux C, Gonschorek P, Tsoi LC, Gudjonsson JE, Schilling O, Hovnanian A. Commun Biol, 2024 Feb 5; 7 (1): 152Journal ArticleComparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.
DOI:10.1038/s42003-024-05780-y PMID: 38316920 -
Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210Journal ArticleSystems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
DOI:10.1038/s41467-023-44645-6 PMID: 38172207 -
Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210Journal ArticleSystems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
DOI:10.1038/s41467-023-44645-6 PMID: 38172207 -
Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE. iScience, 2024 Feb 16; 27 (2): 108986Journal ArticleHERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
DOI:10.1016/j.isci.2024.108986 PMID: 38327798 -
Uppala R, Sarkar MK, Young KZ, Ma F, Vemulapalli P, Wasikowski R, Plazyo O, Swindell WR, Maverakis E, Gharaee-Kermani M, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE. iScience, 2024 Feb 16; 27 (2): 108986Journal ArticleHERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling.
DOI:10.1016/j.isci.2024.108986 PMID: 38327798 -
Cohen E, Johnson CN, Wasikowski R, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, Coulombe PA. iScience, 2024 Feb 16; 27 (2): 108805Journal ArticleSignificance of stress keratin expression in normal and diseased epithelia.
DOI:10.1016/j.isci.2024.108805 PMID: 38299111 -
Cohen E, Johnson CN, Wasikowski R, Billi AC, Tsoi LC, Kahlenberg JM, Gudjonsson JE, Coulombe PA. iScience, 2024 Feb 16; 27 (2): 108805Journal ArticleSignificance of stress keratin expression in normal and diseased epithelia.
DOI:10.1016/j.isci.2024.108805 PMID: 38299111
