Lam (Alex) C Tsoi, PhD
Assistant Professor of Dermatology
Assistant Professor of Computational Medicine and Bioinformatics
Research Assistant Professor, Mary H Weiser Food Allergy
Research Assistant Professor, Biostatistics
[email protected]

Available to mentor
Lam (Alex) C Tsoi, PhD
Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
    • About

    My research focuses on identifying the genetic and genomic components for psoriasis, and understanding their biological effect and contribution to disease heterogeneity. I currently direct the Center for Cutaneous Bioinformatics at the University of Michigan, and I am the associate director of the Functional Analytic Core of the P30-funded University of Michigan Skin Biology Disease and Resource Center.
    I have been actively involved in coordinating and conducting different genetic and genomic studies to understand the pathophysiology of different immune-mediated disorders including psoriasis, psoriatic arthritis, atopic dermatitis, and cutaneous lupus. By using systems biology approaches, we have revealed robust disease associated signals and candidates for downstream functional assays of psoriasis and facilitated the identification of genetic signature for psoriatic arthritis risk. My research also focuses on the development and implementation of computational pipeline for genomic data to identify novel disease-associated transcripts as well as context-specific inflammatory responses for inflammatory disorders.

    Qualifications
    • Research Fellow
      University of Michigan, Biostatistics, 2015
    Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Precision Health Initiative
    • Center Member
      Global REACH
    Recent Publications See All Publications
    • Journal Article
      Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.
      Petrova E, López-Gay JM, Fahrner M, Leturcq F, de Villartay J-P, Barbieux C, Gonschorek P, Tsoi LC, Gudjonsson JE, Schilling O, Hovnanian A. Commun Biol, 2024 Feb 5; 7 (1): 152 DOI:10.1038/s42003-024-05780-y
      PMID: 38316920
    • Journal Article
      Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
      Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Sep 5; 149: 103296 DOI:10.1016/j.jaut.2024.103296
      PMID: 39241536
    • Journal Article
      Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
      Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210 DOI:10.1038/s41467-023-44645-6
      PMID: 38172207
    • Journal Article
      tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data.
      Duan J, Ngo MN, Karri SS, Tsoi LC, Gudjonsson JE, Shahbaba B, Lowengrub J, Andersen B. Nat Commun, 2024 May 7; 15 (1): 3840 DOI:10.1038/s41467-024-48041-6
      PMID: 38714698
    • Journal Article
      Secondary ACMG and non-ACMG genetic findings in a multiethnic cohort of 16,713 pediatric participants.
      Saeidian AH, March ME, Youssefian L, Watson DJ, Bhandari E, Wang X, Zhao X, Owen NM, Strong A, Harr MH, CAG Secondary Finding Consortium , Bhoj E, Zackai E, Vahidnezhad H, Gudjonsson JE, Cederbaum SD, Deignan JL, Glessner J, Grody WW, Hakonarson H. Genet Med, 2024 Jul 31; 26 (11): 101225 DOI:10.1016/j.gim.2024.101225
      PMID: 39096151
    • Journal Article
      The STAT3/SETDB2 axis dictates NF-κB-mediated inflammation in macrophages during wound repair.
      Mangum KD, denDekker A, Li Q, Tsoi LC, Joshi AD, Melvin WJ, Wolf SJ, Moon JY, Audu CO, Shadiow J, Obi AT, Wasikowski R, Barrett EC, Bauer TM, Boyer K, Ahmed Z, Davis FM, Gudjonsson J, Gallagher KA. JCI Insight, 2024 Oct 22; 9 (20): DOI:10.1172/jci.insight.179017
      PMID: 39435663
    • Proceeding / Abstract / Poster
      53910 Single Cell and Spatial Profiling of Cutaneous Lichen Planus Treated with Baricitinib
      Kechter J, Hwang A, Li X, Hughes A, Tsoi L, Pittelkow M, Gudjonsson J, Mangold A. Journal of the American Academy of Dermatology, 2024 Sep; 91 (3): ab310 DOI:10.1016/j.jaad.2024.07.1235
    • Proceeding / Abstract / Poster
      Diabetic Wound Keratinocytes Induce Macrophage JMJD3-Mediated Nlrp3 Expression via IL-1R Signaling.
      Wolf SJ, Audu CO, Moon JY, Joshi AD, Melvin WJ, Barrett EC, Mangum K, de Jimenez GS, Rocco S, Buckley S, Ahmed Z, Wasikowski R, Kahlenberg JM, Tsoi LC, Gudjonsson JE, Gallagher KA. Diabetes, 2024 Sep 1; 73 (9): 1462 - 1472. DOI:10.2337/db23-0968
      PMID: 38869447