Lam (Alex) C Tsoi, PhD
Assistant Professor of Dermatology
Assistant Professor of Computational Medicine and Bioinformatics
Research Assistant Professor, Mary H Weiser Food Allergy
Research Assistant Professor, Biostatistics
[email protected]

Available to mentor
Lam (Alex) C Tsoi, PhD
Assistant Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
    • About

    My research focuses on identifying the genetic and genomic components for psoriasis, and understanding their biological effect and contribution to disease heterogeneity. I currently direct the Center for Cutaneous Bioinformatics at the University of Michigan, and I am the associate director of the Functional Analytic Core of the P30-funded University of Michigan Skin Biology Disease and Resource Center.
    I have been actively involved in coordinating and conducting different genetic and genomic studies to understand the pathophysiology of different immune-mediated disorders including psoriasis, psoriatic arthritis, atopic dermatitis, and cutaneous lupus. By using systems biology approaches, we have revealed robust disease associated signals and candidates for downstream functional assays of psoriasis and facilitated the identification of genetic signature for psoriatic arthritis risk. My research also focuses on the development and implementation of computational pipeline for genomic data to identify novel disease-associated transcripts as well as context-specific inflammatory responses for inflammatory disorders.

    Qualifications
    • Research Fellow
      University of Michigan, Biostatistics, 2015
    Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Precision Health Initiative
    • Center Member
      Global REACH
    Recent Publications See All Publications
    • Journal Article
      342 Molecular characterization of secondary syphilis through bulk, single-cell analyses and identification of the role of MYD88 in cellular responses to Treponema pallidum
      Sérézal IG, Kirma J, Sarkar M, Xing X, Bogle R, Coon A, Harms PW, Tsoi LC, Giacani L, Gudjonsson JE. Journal of Investigative Dermatology, 2024 Dec; 144 (12): s287 DOI:10.1016/j.jid.2024.10.351
    • Journal Article
      Comparative analyses of Netherton syndrome patients and Spink5 conditional knock-out mice uncover disease-relevant pathways.
      Petrova E, López-Gay JM, Fahrner M, Leturcq F, de Villartay J-P, Barbieux C, Gonschorek P, Tsoi LC, Gudjonsson JE, Schilling O, Hovnanian A. Commun Biol, 2024 Feb 5; 7 (1): 152 DOI:10.1038/s42003-024-05780-y
      PMID: 38316920
    • Journal Article
      Lupus-prone NZM2328 mice exhibit enhanced UV-induced myeloid cell recruitment and activation in a type I interferon dependent manner.
      Maz MP, Reddy AL, Berthier CC, Tsoi LC, Colesa DJ, Wolf SJ, Shi H, Loftus SN, Moallemian R, Bogle R, Kretzler M, Jacob CO, Gudjonsson JE, Kahlenberg JM. J Autoimmun, 2024 Dec; 149: 103296 DOI:10.1016/j.jaut.2024.103296
      PMID: 39241536
    • Journal Article
      Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis.
      Ma F, Tsou P-S, Gharaee-Kermani M, Plazyo O, Xing X, Kirma J, Wasikowski R, Hile GA, Harms PW, Jiang Y, Xing E, Nakamura M, Ochocki D, Brodie WD, Pillai S, Maverakis E, Pellegrini M, Modlin RL, Varga J, Tsoi LC, Lafyatis R, Kahlenberg JM, Billi AC, Khanna D, Gudjonsson JE. Nat Commun, 2024 Jan 3; 15 (1): 210 DOI:10.1038/s41467-023-44645-6
      PMID: 38172207
    • Journal Article
      tauFisher predicts circadian time from a single sample of bulk and single-cell pseudobulk transcriptomic data.
      Duan J, Ngo MN, Karri SS, Tsoi LC, Gudjonsson JE, Shahbaba B, Lowengrub J, Andersen B. Nat Commun, 2024 May 7; 15 (1): 3840 DOI:10.1038/s41467-024-48041-6
      PMID: 38714698
    • Preprint
      Activation of IL1A/IRAK1 axis and downstream proinflammatory signaling in healthy adult and neonatal African American skin
      Trubetskoy D, Grudzien P, Klopot A, Tsoi LC, Kundu RV, White BEP, Budunova I. bioRxiv, DOI:10.1101/2024.11.18.624144
    • Journal Article
      Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+ CD8+ T-cells.
      Hwang AS, Kechter JA, Do TH, Hughes AN, Zhang N, Li X, Bogle R, Brumfiel CM, Patel MH, Boudreaux B, Bhullar P, Nassir S, Yousif ML, Stockard AL, Leibovit-Reiben Z, Ogbaudu E, DiCaudo DJ, Fox J, Gharaee-Kermani M, Xing X, Zunich S, Branch E, Kahlenberg JM, Billi AC, Plazyo O, Tsoi LC, Pittelkow MR, Gudjonsson JE, Mangold AR. J Clin Invest, 2024 Nov 14; DOI:10.1172/JCI179436
      PMID: 39541169
    • Journal Article
      Disease heterogeneity and molecular classification of inflammatory palmoplantar diseases.
      van Straalen KR, Kirma J, Yee CM, Bugada LF, Rizvi SM, Wen F, Wasikowski R, Fox J, Do TH, Schuler CF, Xing E, MacLeod AS, Harms PW, Berthier CC, Kahlenberg JM, Leung MWL, Tsoi LC, Gudjonsson JE. J Allergy Clin Immunol, 2024 Nov; 154 (5): 1204 - 1215.e9. DOI:10.1016/j.jaci.2024.07.017
      PMID: 39089334