David P Olson, MD, PhD
David Murray Cowie M.D. Research Professor of Pediatrics
Associate Professor of Pediatrics
Associate Professor of Molecular and Integrative Physiology and Associate Chair, Research
Department of Pediatrics Primary Care
[email protected]

Available to mentor
David P Olson, MD, PhD
Associate Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core. Dr. Olson also serves as the Associate Chair for Research in Pediatrics.

    Qualifications
    • Fellow
      Boston Children's Hospital, Pediatrics, 2005
    • Resident
      Boston Children's Hospital, Pediatrics, 2002
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.

    Recent Publications See All Publications
    • Journal Article
      SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.
      Li Y, Kim M-H, Jiang L, Baron L, Faulkner LD, Olson DP, Li X, Gannot N, Li P, Rui L. Adv Sci (Weinh), 2024 Aug; 11 (31): e2400437 DOI:10.1002/advs.202400437
      PMID: 38885417
    • Journal Article
      Cardiovascular Outcomes in GRADE (Glycemia Reduction Approaches in Type 2 Diabetes: A Comparative Effectiveness Study).
      Green JB, Everett BM, Ghosh A, Younes N, Krause-Steinrauf H, Barzilay J, Desouza C, Inzucchi SE, Pokharel Y, Schade D, Scrymgeour A, Tan MH, Utzschneider KM, Mudaliar S, GRADE Study Research Group . Circulation, 2024 Mar 26; 149 (13): 993 - 1003. DOI:10.1161/CIRCULATIONAHA.123.066604
      PMID: 38344820
    • Journal Article
      Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866 DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      National Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists.
      Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A, Burns A, Orange JS, NPSCW . Pediatr Res, 2024 Jan; 95 (1): 70 - 74. DOI:10.1038/s41390-023-02795-9
      PMID: 37684431
    • Journal Article
      Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
      Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG. J Clin Invest, 2023 Oct 2; 133 (19): DOI:10.1172/JCI157515
      PMID: 37581939
    • Presentation
      Central Glp1R signaling and energy balance
      Olson D. 2023 Mar 13;
    • Chapter
      Brain Regulation of Feeding and Energy Homeostasis
      Affinati AH, Elias CF, Olson DP, Myers MG. 2023 Metabolic Syndrome, 283 - 301. DOI:10.1007/978-3-031-40116-9_22
    • Proceeding / Abstract / Poster
      210-LB: Central Regulation of Peripheral Adiposity by Nos1PVHNeurons
      FAULKNER LD, LEWIS K, MEEK TH, MERCER AJ, MACDOUGALD OA, OLSON D. Diabetes, 2022 Jun 1; 71 (Supplement_1): DOI:10.2337/db22-210-lb