David P Olson, MD, PhD
David Murray Cowie M.D. Research Professor of Pediatrics
Associate Professor of Pediatrics
Associate Professor of Molecular and Integrative Physiology and Associate Chair
Research
Department of Pediatrics Primary Care
[email protected]

Available to mentor

David P Olson, MD, PhD
Associate Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core. Dr. Olson also serves as the Associate Chair for Research in Pediatrics.

    Qualifications
    • Fellow
      Boston Children's Hospital, Pediatrics, 2005
    • Resident
      Boston Children's Hospital, Pediatrics, 2002
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.

    Recent Publications See All Publications
    • Journal Article
      Impact of Glucose-Lowering Medications on Health-Related Quality of Life in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
      Cherrington AL, Tripputi MT, Younes N, Herman WH, Katona A, Groessl EJ, Craig J, Gonzalez JS, Garg R, Casula S, Kuo S, Florez HJ, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 603 - 609. DOI:10.2337/dc23-1648
      PMID: 38190625
    • Journal Article
      Longitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
      Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 580 - 588. DOI:10.2337/dc23-1070
      PMID: 38211595
    • Journal Article
      Mortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
      Banerji MA, Buse JB, Younes N, Krause-Steinrauf H, Ghazi A, Lee M, Park J, Pop-Busui R, Underkofler C, Fortmann SP, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 589 - 593. DOI:10.2337/dc23-1356
      PMID: 38252886
    • Journal Article
      The Use of Rescue Insulin in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
      Hollander PA, Krause-Steinrauf H, Butera NM, Kazemi EJ, Ahmann AJ, Fattaleh BN, Johnson ML, Killean T, Lagari VS, Larkin ME, Legowski EA, Rasouli N, Willis HJ, Martin CL, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 638 - 645. DOI:10.2337/dc23-0516
      PMID: 37756542
    • Journal Article
      Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866 DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      National Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists.
      Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A, Burns A, Orange JS, NPSCW . Pediatr Res, 2024 Jan; 95 (1): 70 - 74. DOI:10.1038/s41390-023-02795-9
      PMID: 37684431
    • Journal Article
      SH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.
      Li Y, Kim M-H, Jiang L, Baron L, Faulkner LD, Olson DP, Li X, Gannot N, Li P, Rui L. Adv Sci (Weinh), 2024 Aug; 11 (31): e2400437 DOI:10.1002/advs.202400437
      PMID: 38885417
    • Journal Article
      Suppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
      Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG. J Clin Invest, 2023 Oct 2; 133 (19): DOI:10.1172/JCI157515
      PMID: 37581939