Available to mentor
Dr. Olson is a physician scientist with clinical training in pediatrics and pediatric endocrinology. He leads a research laboratory focused on dissecting the neural mechanisms of energy balance control and metabolism. He is Co-director of the T32 training grant in Pediatric Endocrinology and is the Director of the Michigan Diabetes Research Center's Molecular Genetics Core. Dr. Olson also serves as the Associate Chair for Research in Pediatrics.
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FellowBoston Children's Hospital, Pediatrics, 2005
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ResidentBoston Children's Hospital, Pediatrics, 2002
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Center MemberCaswell Diabetes Institute
The Olson lab is committed to determining the mechanisms by which the brain regulates feeding, energy expenditure, body weight and glucose metabolism. Our research uses advanced molecular genetic techniques to manipulate discrete subsets of neurons in the hypothalamus and hindbrain. Using rodent models, we aim to determine the role that specific neurons play in energy homeostasis, feeding behavior and peripheral glucose handling.
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Cherrington AL, Tripputi MT, Younes N, Herman WH, Katona A, Groessl EJ, Craig J, Gonzalez JS, Garg R, Casula S, Kuo S, Florez HJ, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 603 - 609.Journal ArticleImpact of Glucose-Lowering Medications on Health-Related Quality of Life in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
DOI:10.2337/dc23-1648 PMID: 38190625 -
Rasouli N, Younes N, Ghosh A, Albu J, Cohen RM, DeFronzo RA, Diaz E, Sayyed Kassem L, Luchsinger JA, McGill JB, Sivitz WI, Tamborlane WV, Utzschneider KM, Kahn SE, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 580 - 588.Journal ArticleLongitudinal Effects of Glucose-Lowering Medications on β-Cell Responses and Insulin Sensitivity in Type 2 Diabetes: The GRADE Randomized Clinical Trial.
DOI:10.2337/dc23-1070 PMID: 38211595 -
Banerji MA, Buse JB, Younes N, Krause-Steinrauf H, Ghazi A, Lee M, Park J, Pop-Busui R, Underkofler C, Fortmann SP, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 589 - 593.Journal ArticleMortality in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
DOI:10.2337/dc23-1356 PMID: 38252886 -
Hollander PA, Krause-Steinrauf H, Butera NM, Kazemi EJ, Ahmann AJ, Fattaleh BN, Johnson ML, Killean T, Lagari VS, Larkin ME, Legowski EA, Rasouli N, Willis HJ, Martin CL, GRADE Research Group . Diabetes Care, 2024 Apr 1; 47 (4): 638 - 645.Journal ArticleThe Use of Rescue Insulin in the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE).
DOI:10.2337/dc23-0516 PMID: 37756542 -
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866Journal ArticleHepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
DOI:10.1126/scitranslmed.adk1866 PMID: 38478630 -
Moore DJ, Powell W, Boyer D, Bline K, Harshman L, Nowalk A, Burns A, Orange JS, NPSCW . Pediatr Res, 2024 Jan; 95 (1): 70 - 74.Journal ArticleNational Pediatrician-Scientist Collaborative Workgroup comment on new ACGME requirements' impact on pediatric physician-scientists.
DOI:10.1038/s41390-023-02795-9 PMID: 37684431 -
Li Y, Kim M-H, Jiang L, Baron L, Faulkner LD, Olson DP, Li X, Gannot N, Li P, Rui L. Adv Sci (Weinh), 2024 Aug; 11 (31): e2400437Journal ArticleSH2B1 Defends Against Energy Imbalance, Obesity, and Metabolic Disease via a Paraventricular Hypothalamus→Dorsal Raphe Nucleus Neurocircuit.
DOI:10.1002/advs.202400437 PMID: 38885417 -
Rupp AC, Tomlinson AJ, Affinati AH, Yacawych WT, Duensing AM, True C, Lindsley SR, Kirigiti MA, MacKenzie A, Polex-Wolf J, Li C, Knudsen LB, Seeley RJ, Olson DP, Kievit P, Myers MG. J Clin Invest, 2023 Oct 2; 133 (19):Journal ArticleSuppression of food intake by Glp1r/Lepr-coexpressing neurons prevents obesity in mouse models.
DOI:10.1172/JCI157515 PMID: 37581939
