Tobias W Giessen
Assistant Professor of Biological Chemistry
[email protected]

Available to mentor

Tobias W Giessen
Assistant Professor
  • About
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  • Recent Publications
  • About

    The Giessen Lab is interested in the structure, function, and engineering of protein organelles, protein machines, and enzyme filaments. Our current focus lies on microbial protein organelles, compartments, and filaments involved in detoxification, nutrient utilization, and natural product biosynthesis, as well as on the discovery and characterization of novel enzyme machines and assemblies involved in the biosynthesis of bioactive compounds. We endeavor to leverage our molecular level insights into large protein assemblies for synthetic biology applications in drug delivery, biocatalysis, and bionanotechnology. Our interdisciplinary work utilizes techniques and approaches spanning the fields of biochemistry, structural biology (cryo-EM and x-ray crystallography), microbiology and synthetic biology.

    • Giessen Lab Website
    • Tobias W. Giessen - Google Scholar
    • Postdoctoral Research Fellow
      Harvard Medical School, Systems Biology, 2018
    • Postdoctoral Research Fellow
      Wyss Institute for Biologically Inspired Engineering at Harvard, Synthetic Biology, 2018
    • Postdoctoral Research Fellow
      Loewe Center for Synthetic Microbiology, Marburg, 2014
    • PhD in Biochemistry
      Philipps-University Marburg, Marburg, 2013
    • Diplom (BS/MS) in Chemistry
      Philipps-University Marburg, Marburg, 2010
    Recent Publications See All Publications
    • Preprint
      Structural and biochemical characterization of an encapsulin-associated rhodanese from Acinetobacter baumannii.
      Benisch R, Giessen TW. 2024 Mar 5; DOI:10.1101/2024.02.19.581022
      PMID: 38464153
    • Patent
      Protein-based bacterial nanocompartments
      Giessen T, Kwon S.
    • Journal Article
      A widespread bacterial protein compartment sequesters and stores elemental sulfur.
      Benisch R, Andreas MP, Giessen TW. Sci Adv, 2024 Feb 2; 10 (5): eadk9345 DOI:10.1126/sciadv.adk9345
      PMID: 38306423
    • Preprint
      Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages.
      Szyszka TN, Andreas MP, Lie F, Miller LM, Adamson LSR, Fatehi F, Twarock R, Draper BE, Jarrold MF, Giessen TW, Lau YH. 2024 Feb 6; DOI:10.1101/2024.02.05.579038
      PMID: 38370832
    • Journal Article
      A team of dynein motor proteins drives microtubule-based trafficking of HIV-1
      Badieyan S, Andreas MP, Shi J, Aiken C, Giessen TW, Cianfrocco MA. Biophysical Journal, 2024 Feb; 123 (3): 125a DOI:10.1016/j.bpj.2023.11.860
    • Preprint
      HIV-1 binds dynein directly to hijack microtubule transport machinery.
      Badieyan S, Lichon D, Andreas MP, Gillies JP, Peng W, Shi J, DeSantis ME, Aiken CR, Böcking T, Giessen TW, Campbell EM, Cianfrocco MA. 2023 Dec 2; DOI:10.1101/2023.08.29.555335
      PMID: 37693451
    • Journal Article
      Structure and heterogeneity of a highly cargo-loaded encapsulin shell.
      Kwon S, Andreas MP, Giessen TW. J Struct Biol, 2023 Dec; 215 (4): 108022 DOI:10.1016/j.jsb.2023.108022
      PMID: 37657675
    • Preprint
      Cyclodipeptide oxidase is an enzyme filament.
      Andreas MP, Giessen TW. 2023 Sep 25; DOI:10.1101/2023.09.25.559410
      PMID: 37808672
    Featured News & Stories Structure of the filamentous protein cyclodipeptide oxidase AlbAB
    Department News
    The Giessen lab publishes two new papers and receives research awards from the National Science Foundation
    Recent research achievements from the Giessen lab.
    Cutaway view of an self-assembling protein nanocompartment
    Department News
    The Giessen lab publishes a research article in Nature Communications
    The Giessen lab publishes a research article in Nature Communications.