Uhn-Soo Cho, PhD
Associate Professor of Biological Chemistry
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220E MSRB III
Ann Arbor, MI 48109
[email protected]

Available to mentor

Uhn-Soo Cho, PhD
Associate Professor
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
  • Qualifications
    • HHMI Postdoctoral Fellow
      Harvard Medical School, Boston, 2012
    • PhD
      University of Washington, Seattle, 2007
    • MS
      Korea University, Seoul, 2000
    • BS
      Korea University, Seoul, 1998
    Research Overview

    Our laboratory is interested in illustrating the molecular mechanisms of key biological events, particularly epigenetic regulation and metabolic homeostasis, using structural biology as major tools. We use X-ray crystallography and cryogenic electron microscopy to determine the atomic level of macromolecular structures to understand its mechanisms.

    • The Cho laboratory
    Recent Publications See All Publications
    • Journal Article
      Non-canonical MLL1 activity regulates centromeric phase separation and genome stability.
      Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz H-J, An W, Cho U-S, Dou Y. Nat Cell Biol, 2023 Nov; 25 (11): 1637 - 1649. DOI:10.1038/s41556-023-01270-1
      PMID: 37945831
    • Journal Article
      Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase.
      Ahn E, Kim B, Park S, Erwin AL, Sung SH, Hovden R, Mosalaganti S, Cho U-S. ACS Nano, 2023 Mar 28; 17 (6): 6011 - 6022. DOI:10.1021/acsnano.3c00463
      PMID: 36926824
    • Journal Article
      Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy.
      Cobb T, Hwang I, Soukar M, Namkoong S, Cho U-S, Safdar M, Kim M, Wessells RJ, Lee JH. Proc Natl Acad Sci U S A, 2023 Sep 26; 120 (39): e2220556120 DOI:10.1073/pnas.2220556120
      PMID: 37722048
    • Journal Article
      Development of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids.
      Ahn E, Tang T, Kim B, Lee HJ, Cho U-S. J Biol Chem, 2022 Apr; 298 (4): 101793 DOI:10.1016/j.jbc.2022.101793
      PMID: 35248533
    • Patent
    • Journal Article
      Regulation of MLL1 Methyltransferase Activity in Two Distinct Nucleosome Binding Modes.
      Ayoub A, Park SH, Lee Y-T, Cho U-S, Dou Y. Biochemistry, 2022 Jan 4; 61 (1): 1 - 9. DOI:10.1021/acs.biochem.1c00603
      PMID: 34928138
    • Preprint
      Batch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of <i>Methylococcus capsulatus</i> Soluble Methane Monooxygenase Hydroxylase
      Ahn E, Kim B, Park S, Erwin A, Sung SH, Hovden R, Mosalaganti S, Cho U-S. 2021 bioRxiv, DOI:10.1101/2021.12.26.474209
    • Presentation
      Structural Biology in the time of COVID-19
      2021 Jun 1;
    Featured News & Stories
    Department News
    Cho lab publishes research article in ACS Nano
    The Cho lab published a research article in ACS Nano.