Associate Professor of Biological Chemistry
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220E MSRB III
Ann Arbor, MI 48109
[email protected]
1150 W. Medical Center Dr., 4220E MSRB III
Ann Arbor, MI 48109
Available to mentor
Uhn-Soo Cho, PhD
Associate Professor
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HHMI Postdoctoral FellowHarvard Medical School, Boston, 2012
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PhDUniversity of Washington, Seattle, 2007
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MSKorea University, Seoul, 2000
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BSKorea University, Seoul, 1998
Our laboratory is interested in illustrating the molecular mechanisms of key biological events, particularly epigenetic regulation and metabolic homeostasis, using structural biology as major tools. We use X-ray crystallography and cryogenic electron microscopy to determine the atomic level of macromolecular structures to understand its mechanisms.
The Cho laboratory
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Cho U-S. 2024 Jul 5;BookThe Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome
DOI:10.1007/978-3-031-58843-3_6 -
Thamkachy R, Medina-Pritchard B, Park SH, Chiodi CG, Zou J, de la Torre-Barranco M, Shimanaka K, Abad MA, Gallego Páramo C, Feederle R, Ruksenaite E, Heun P, Davies OR, Rappsilber J, Schneidman-Duhovny D, Cho U-S, Jeyaprakash AA. EMBO Rep, 2024 Jul 1;Journal ArticleStructural basis for Mis18 complex assembly and its implications for centromere maintenance.
DOI:10.1038/s44319-024-00183-w PMID: 38951710 -
Cho U-S. Subcell Biochem, 2024 104: 101 - 117.Journal ArticleThe Core Complex of Yeast COMPASS and Human Mixed-Lineage Leukemia (MLL), Structure, Function, and Recognition of the Nucleosome.
DOI:10.1007/978-3-031-58843-3_6 PMID: 38963485 -
Sha L, Yang Z, An S, Yang W, Kim S, Oh H, Xu J, Yin J, Wang H, Lenz H-J, An W, Cho U-S, Dou Y. Nat Cell Biol, 2023 Nov; 25 (11): 1637 - 1649.Journal ArticleNon-canonical MLL1 activity regulates centromeric phase separation and genome stability.
DOI:10.1038/s41556-023-01270-1 PMID: 37945831 -
Ahn E, Kim B, Park S, Erwin AL, Sung SH, Hovden R, Mosalaganti S, Cho U-S. ACS Nano, 2023 Mar 28; 17 (6): 6011 - 6022.Journal ArticleBatch Production of High-Quality Graphene Grids for Cryo-EM: Cryo-EM Structure of Methylococcus capsulatus Soluble Methane Monooxygenase Hydroxylase.
DOI:10.1021/acsnano.3c00463 PMID: 36926824 -
Cobb T, Hwang I, Soukar M, Namkoong S, Cho U-S, Safdar M, Kim M, Wessells RJ, Lee JH. Proc Natl Acad Sci U S A, 2023 Sep 26; 120 (39): e2220556120Journal ArticleIditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy.
DOI:10.1073/pnas.2220556120 PMID: 37722048 -
Ahn E, Tang T, Kim B, Lee HJ, Cho U-S. J Biol Chem, 2022 Apr; 298 (4): 101793Journal ArticleDevelopment of an atmospheric plasma jet device for versatile treatment of electron microscope sample grids.
DOI:10.1016/j.jbc.2022.101793 PMID: 35248533 -
PatentGRAPHENE SUPPORTED CRYO-ELECTRON MICROSCOPY GRID
Department News
The Cho lab published a research article in ACS Nano.
