Available to mentor
Dr. Peter Higgins received his bachelor's degree and medical degrees from Duke University, and completed a Ph.D. in molecular cancer biology at Duke. He completed a fellowship in gastroenterology at the University of Michigan in 2004, completed an M.Sc. in Clinical Research Design and Statistical Analysis at the University of Michigan School of Public Health, and joined the University of Michigan faculty the same year. Dr. Higgins currently serves as the IBD editor for the American Journal of Gastroenterology. His research focuses on inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. He is interested in the molecular mechanisms of intestinal fibrosis, which leads to intestinal blockages and surgery. Dr. Higgins studies the use of ultrasound to measure intestinal scarring, the use of biomarkers to detect early scarring, and measurement of markers of early inflammation. His clinical research includes studies on patient-reported outcomes in IBD, medication holidays after long-term remission in IBD, and biomarker-guided therapy in IBD. Dr. Higgins' research interests are complemented by his clinical interest in improving the quality of care of patients with IBD. He is a member of the AGA IBD Quality Measures Committee, and has participated in the development of national guidelines for high quality IBD care. Dr. Higgins has received many honors and awards, including the AGA IBD Clinical Research Excellence Award.
Higgins IBD Program
Detection and measurement of inflammation in inflammatory bowel disease (IBD). Mechanisms of intestinal fibrosis, and measurement of fibrosis with ultrasound and biomarkers. Medication holidays after long-term IBD remission. Patient-reported outcomes in IBD.
-
Lee S-H, Turpin W, Espin-Garcia O, Xu W, Croitoru K, Crohn's and Colitis Canada-Genetic, Environmental, Microbial (CCC-GEM) Project Research Consortium . Gastroenterology, 2025 Jan; 168 (1): 150 - 153.e4.Additional ScholarshipDevelopment and Validation of an Integrative Risk Score for Future Risk of Crohn's Disease in Healthy First-Degree Relatives: A Multicenter Prospective Cohort Study.
DOI:10.1053/j.gastro.2024.08.021 PMID: 39209122 -
Lee S-H, Bushra M, Qiu L, Griffiths AM, Turpin W, Croitoru K, Crohn’s and Colitis Canada-Genetic, Environmental, Microbial (CCC-GEM) Project Research Consortium , Lee S-H, Bushra M, Qiu L, Shao J, Olivera PA, Leibovitzh H, Xue M, Xu W, Espin-Garcia O, Amuais GL, Huynh HQ, Panaccione R, Steinhart AH, Cino M, Mack D, Marshall J, Ropeleski M, Bitton A, Jacobson K, McGrath J, Yerushalmi B, Abreu MT, Bernstein CN, Radford-Smith G, Lees C, Turner D, Madsen K, Guttman DS, Silverberg M, Griffiths AM, Moayyedi P, Turpin W, Beck P, Dieleman L, Feagan BG, Kaplan G, Krause DO, Seidman E, Snapper S, Stadnyk A, Surette M, Walters T, Vallance B, Critch J, Denson L, Deslandres C, El-Matary W, Herfarth H, Higgins P, Hyams J, Otley A, Hedin C, Hussey S, Keljo D, Kevans D, Murthy S, Parekh N, Plamondon S, Rosh J, Rubin D, Schultz M, Siegel C, Croitoru K. Gastroenterology, 2024 Oct 9;Journal ArticleEarly Life Exposure to Parental Crohn's Disease Is Associated With Offspring's Gut Microbiome, Gut Permeability, and Increased Risk of Future Crohn's Disease.
DOI:10.1053/j.gastro.2024.09.033 PMID: 39384162 -
Olivera PA, Martinez-Lozano H, Leibovitzh H, Xue M, Neustaeter A, Espin-Garcia O, Xu W, Madsen KL, Guttman DS, Bernstein CN, Yerushalmi B, Hyams JS, Abreu MT, Marshall JK, Wrobel I, Mack DR, Jacobson K, Bitton A, Aumais G, Panacionne R, Dieleman LA, Silverberg MS, Steinhart AH, Moayyedi P, Turner D, Griffiths AM, Turpin W, Lee S-H, Croitoru K, Crohn’s and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium . Gastroenterology, 2025 Jan; 168 (1): 99 - 110.e2.Journal ArticleHealthy First-Degree Relatives From Multiplex Families vs Simplex Families Have Higher Subclinical Intestinal Inflammation, a Distinct Fecal Microbial Signature, and Harbor a Higher Risk of Developing Crohn's Disease.
DOI:10.1053/j.gastro.2024.08.031 PMID: 39236898 -
D'Haens G, Higgins PDR, Peyrin-Biroulet L, Sands BE, Lee S, Moses RE, Redondo I, Escobar R, Hunter Gibble T, Keohane A, Morris N, Zhang X, Arora V, Kobayashi T. Inflamm Bowel Dis, 2024 Dec 5; 30 (12): 2335 - 2346.Proceeding / Abstract / PosterExtended Induction and Prognostic Indicators of Response in Patients Treated with Mirikizumab with Moderately to Severely Active Ulcerative Colitis in the LUCENT Trials.
DOI:10.1093/ibd/izae004 PMID: 38271613 -
Koleck TA, Dreisbach C, Zhang C, Grayson S, Lor M, Deng Z, Conway A, Higgins PDR, Bakken S. J Am Med Inform Assoc, 2024 Dec 1; 31 (12): 3032 - 3041.Journal ArticleUser guide for Social Determinants of Health Survey data in the All of Us Research Program.
DOI:10.1093/jamia/ocae214 PMID: 39190874 -
Golob J, Rao K, Berinstein JA, Singh P, Chey WD, Owyang C, Kamada N, Higgins PDR, Young V, Bishu S, Lee AA. Inflamm Bowel Dis, 2024 Nov 14;Journal ArticleWhy Symptoms Linger in Quiescent Crohn's Disease: Investigating the Impact of Sulfidogenic Microbes and Sulfur Metabolic Pathways.
DOI:10.1093/ibd/izae238 PMID: 39541261 -
Cushing-Damm KC, Chen Y, Du X, Kuppa A, Raut C, Oliveri A, Chen VL, Vanderwerff B, Zawistowski M, Rao K, Higgins P, Speliotes EK. mSphere, 2024 Nov 21; 9 (11): e0056724Journal ArticleGenetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection.
DOI:10.1128/msphere.00567-24 PMID: 39436105 -
Sheehan JL, Greene-Higgs L, Resnicow K, Patel MR, Barnes EL, Waljee AK, Higgins PDR, Cohen-Mekelburg S. Dig Dis Sci, 2024 Nov; 69 (11): 4089 - 4097.Journal ArticleSelf-Efficacy, Patient Activation, and the Burden of Inflammatory Bowel Disease on Patients' Daily Lives.
DOI:10.1007/s10620-024-08712-2 PMID: 39460883
