Peter DR Higgins, MD, PhD, MSc(CRDSA), AGAF
Timothy T Nostrant M.D.
Collegiate Professor of Gastroenterology
Professor of Internal Medicine
Medical School
[email protected]

Available to mentor

Peter DR Higgins, MD, PhD, MSc(CRDSA), AGAF
Professor
  • About
  • Links
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Manage Your Profile
    About

    Dr. Peter Higgins received his bachelor's degree and medical degrees from Duke University, and completed a Ph.D. in molecular cancer biology at Duke. He completed a fellowship in gastroenterology at the University of Michigan in 2004, completed an M.Sc. in Clinical Research Design and Statistical Analysis at the University of Michigan School of Public Health, and joined the University of Michigan faculty the same year. Dr. Higgins has previously served as the IBD editor for the American Journal of Gastroenterology, the chair of the AGA Immunology, Microbiology, and IBD section, and chaired the University of Michigan GI Division Research Advisory Council. His research focuses on inflammatory bowel disease, which includes Crohn's disease and ulcerative colitis. He is interested in the molecular mechanisms of intestinal fibrosis, which leads to intestinal blockages and surgery. Dr. Higgins studies novel approaches to Acute Severe Ulcerative Colitis and strictures in Crohn's disease. His clinical research includes studies on patient-reported outcomes in IBD, cell therapies in IBD, and biomarker-guided therapy in IBD. Dr. Higgins' research interests are complemented by his clinical interest in improving the quality of care of patients with IBD. He served as a member of the AGA IBD Quality Measures Committee, and has participated in the development of national guidelines for high quality IBD care. Dr. Higgins currently serves as the NSAC (National Scientific Advisory Committee) chair of the Crohn's and Colitis Foundation. Dr. Higgins has received many honors and awards, including the AGA IBD Clinical Research Excellence Award.

    Links
    • Higgins IBD Program
    Center Memberships
    • Center Member
      Precision Health Initiative
    Research Overview

    Detection and measurement of inflammation in inflammatory bowel disease (IBD). Mechanisms of intestinal fibrosis, and measurement of fibrosis with ultrasound and biomarkers. Development of novel anti-fibrotic and anti-inflammatory therapies. Patient-reported outcomes in IBD.

    Recent Publications See All Publications
    • Journal Article
      Health Outcomes, Discrimination, and Stigma Among Sexual and Gender Minority People With Inflammatory Bowel Disease.
      Newman KL, Wren PA, Long MD, Higgins PDR. Inflamm Bowel Dis, 2025 Apr 8; DOI:10.1093/ibd/izaf054
      PMID: 40197744
    • Preprint
      Immune phenotype-guided identification of disease-associated pathobionts in Crohn’s disease
      Nagao-Kitamoto H, Sugihara K, Kitamoto S, Ebihara S, Kim Y, Newman KL, Alonso U, Suzuki T, Kioi Y, Yunesi A, Inohara N, Alteri CJ, Minar P, Denson LA, Higgins PDR, Kao JY, Bishu S, Xie Y, Lei YL, Kamada N. 2025 Apr 9; bioRxiv, DOI:10.1101/2025.04.01.646605
    • Preprint
      A gut-selective Axl Inhibitor Attenuates Intestinal Fibrosis in myofibroblast cell models and the Mouse S. Typhimurium Model in vivo
      Feng Y, Johnson LA, Clasby M, Higgins PDR. 2025 Apr 6; bioRxiv, DOI:10.1101/2025.03.30.646118
    • Journal Article
      Risankizumab Is Effective for The Management of Crohn’s Disease of the Pouch
      Kayal M, Spencer EA, Smyth M, Raffals L, Qazi T, Deepak P, Beniwal-Patel P, Chang S, Higgins P, Cross RK, Anderson C, Long M, Herfarth HH, Dubinsky MC, Barnes EL. Inflammatory Bowel Diseases, 2025 Mar 1; 31 (3): 878 - 881. DOI:10.1093/ibd/izae164
      PMID: 39038228
    • Journal Article
      Why Symptoms Linger in Quiescent Crohn’s Disease: Investigating the Impact of Sulfidogenic Microbes and Sulfur Metabolic Pathways
      Golob J, Rao K, Berinstein JA, Singh P, Chey WD, Owyang C, Kamada N, Higgins PDR, Young V, Bishu S, Lee AA. Inflammatory Bowel Diseases, 2025 Mar 20; 31 (3): 763 - 776. DOI:10.1093/ibd/izae238
    • Journal Article
      EFFICACY AND SAFETY OF UPADACITINIB FOR ACUTE SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
      Patel A, Hassan SA, Sulbaran M, EL-Najjar Y, Touma M-J, Perry C, Flomenhoft D, Barrett T, Kinnucan J, Higgins P, Fudman D, Berinstein J. Inflammatory Bowel Diseases, 2025 Mar 5; 31 (Supplement_1): s72 - s73. DOI:10.1093/ibd/izae282.168
    • Journal Article
      USING LONGITUDINAL C-REACTIVE PROTEIN MEASUREMENTS THROUGHOUT HOSPITALIZATION TO ASSESS COLECTOMY RISK IN PATIENTS WITH ACUTE SEVERE ULCERATIVE COLITIS
      Abu Omar Y, Gu P, Kayal M, Tedesco N, Goyal M, Bishu S, Cohen-Mekelburg S, Lee A, Stidham R, Waljee A, Higgins P, Berinstein J. Inflammatory Bowel Diseases, 2025 Mar 5; 31 (Supplement_1): s43 - s43. DOI:10.1093/ibd/izae282.099
    • Journal Article
      EFFICACY AND SAFETY OF UPADACITINIB FOR ACUTE SEVERE ULCERATIVE COLITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS
      Patel A, Hassan SA, Sulbaran M, EL-Najjar Y, Touma M-J, Perry C, Flomenhoft D, Barrett T, Kinnucan J, Higgins P, Fudman D, Berinstein J. Gastroenterology, 2025 Mar 1; 168 (3): s102 - s103. DOI:10.1053/j.gastro.2025.01.125
    Featured News & Stories drawing of scientists and doctors up close to insides of stomach
    Health Lab
    How a phone call led Michigan Medicine to become a leader in treating severe ulcerative colitis
    Michigan Medicine becomes leader in treating severe ulcerative colitis with JAK inhibitors.