Frederick G L Huetwell Professor of Cardiovascular Medicine
Professor of Internal Medicine
Professor of Surgery
Professor of Pharmacology
Professor of Molecular and Integrative Physiology
[email protected]
Available to mentor
Yuqing E Chen
Professor
Dr. Chen is an expert in diabetes and cardiovascular disease. He cloned Exendin 4 (BYETTA), facilitating GLP1 drug development. He discovered the mechanisms of nitro-fatty acids, novel anti-inflammatory signaling molecules, currently in phase 2 clinical trials. Recently he embarked in successful integration of human genetic discoveries with translational research.
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Center MemberMM-PKUHSC Joint Institute
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Center MemberCenter for Integrative Research in Critical Care
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Center MemberBiosciences Initiative
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Center MemberCaswell Diabetes Institute
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Sun Y, Zhang Y, Zhang J, Chen YE, Jin J-P, Zhang K, Mou H, Liang X, Xu J. Cell Biosci, 2024 Feb 22; 14 (1): 27Journal ArticleXBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.
DOI:10.1186/s13578-024-01203-x PMID: 38388523 -
Yang Y, Feng H, Tang Y, Wang Z, Qiu P, Huang X, Chang L, Zhang J, Chen YE, Mizrak D, Yang B. Sci Transl Med, 2024 May 8; 16 (746): eadg6298Journal ArticleBioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects.
DOI:10.1126/scitranslmed.adg6298 PMID: 38718134 -
Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866Journal ArticleHepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
DOI:10.1126/scitranslmed.adk1866 PMID: 38478630 -
Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metab, 2024 Jan 2; 36 (1): 116 - 129.e7.Journal ArticleSerine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
DOI:10.1016/j.cmet.2023.12.013 PMID: 38171331 -
Jin T, Chen YE. Cardiovasc Drugs Ther, 2024 Oct 29;Journal ArticleInternational Accolades for GLP-1 Research: Recognizing Pioneers in Diabetes and Obesity Treatment Across Five Prestigious Awards.
DOI:10.1007/s10557-024-07630-9 PMID: 39470894 -
Liu H, Zhao Y, Zhao G, Deng Y, Chen YE, Zhang J. Cells, 2024 Jan 16; 13 (2):Journal ArticleSWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies.
DOI:10.3390/cells13020168 PMID: 38247859 -
Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei H-G, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin J-P, Zhang K, Xu J. JCI Insight, 2024 Feb 15; 9 (6):Journal ArticleSotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits.
DOI:10.1172/jci.insight.165826 PMID: 38358827 -
Liu L, Guo Y, Tian S, Lei I, Gao W, Li Z, Wang S, Chen YE, Wang Z. bioRxiv,PreprintTransient BRD4 degradation improves cardiac reprogramming by inhibiting macrophage/Oncostatin M induced JAK/STAT pathway
DOI:10.1101/2023.12.31.573781