Yuqing E Chen
Frederick G L Huetwell Professor of Cardiovascular Medicine
Professor of Internal Medicine
Professor of Surgery
Professor of Pharmacology
Professor of Molecular and Integrative Physiology
Medical School
[email protected]

Available to mentor
Yuqing E Chen
Professor
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    About

    Dr. Chen is an expert in diabetes and cardiovascular disease. He cloned Exendin 4 (BYETTA), facilitating GLP1 drug development. He discovered the mechanisms of nitro-fatty acids, novel anti-inflammatory signaling molecules, currently in phase 2 clinical trials. Recently he embarked in successful integration of human genetic discoveries with translational research.

    Center Memberships
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Biosciences Initiative
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Recent Publications See All Publications
    • Journal Article
      Vascular smooth muscle cell PRDM16 regulates circadian variation in blood pressure
      Wang Z, Mu W, Zhong J, Xu R, Liu Y, Zhao G, Guo Y, Zhang J, Surakka I, Chen YE, Chang L. Journal of Clinical Investigation, 2025 Feb 3; 135 (3): DOI:10.1172/JCI183409
      PMID: 39625782
    • Journal Article
      International Accolades for GLP-1 Research: Recognizing Pioneers in Diabetes and Obesity Treatment Across Five Prestigious Awards
      Jin T, Chen YE. Cardiovascular Drugs and Therapy, 2025 Feb 1; 39 (1): 9 - 12. DOI:10.1007/s10557-024-07630-9
      PMID: 39470894
    • Journal Article
      XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions
      Sun Y, Zhang Y, Zhang J, Chen YE, Jin JP, Zhang K, Mou H, Liang X, Xu J. Cell and Bioscience, 2024 Dec 1; 14 (1): DOI:10.1186/s13578-024-01203-x
    • Journal Article
      Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects
      Yang Y, Feng H, Tang Y, Wang Z, Qiu P, Huang X, Chang L, Zhang J, Chen YE, Mizrak D, Yang B. Science Translational Medicine, 2024 May 8; 16 (746): DOI:10.1126/scitranslmed.adg6298
      PMID: 38718134
    • Journal Article
      Hepatic danger signaling triggers TREM2<sup>+</sup> macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Science Translational Medicine, 2024 Mar 13; 16 (738): DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
      Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metabolism, 2024 Jan 2; 36 (1): 116 - 129.e7. DOI:10.1016/j.cmet.2023.12.013
      PMID: 38171331
    • Journal Article
      SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies
      Liu H, Zhao Y, Zhao G, Deng Y, Chen YE, Zhang J. Cells, 2024 Jan 1; 13 (2): DOI:10.3390/cells13020168
      PMID: 38247859
    • Journal Article
      Sotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits
      Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei HG, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin JP, Zhang K, Xu J. JCI Insight, 2024 Jan 1; 9 (6): DOI:10.1172/jci.insight.165826
      PMID: 38358827
    Featured News & Stories doctors in surgery room over surgery table with cooler open with labels on it
    Health Lab
    Why donor hearts fail in cold storage — and how to prevent it
    Researchers have discovered a new molecular process that occurs when donor hearts are preserved in cold storage which contributes to failure after transplant, a study in both humans and animals shows. Fortunately, therapy that is typically prescribed for high blood pressure can target this process to reduce cold preservation associated with cardiac injury. This discovery has potential to improve the consistent function of donor hearts and extend the distance they can be safely transported in cold storage.
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    Health Lab
    Drug candidate successfully treats atherosclerosis, fatty liver disease in large mammals 
    A compound that was previously found to treat severe fatty liver disease also reduces atherosclerosis, a primary driver of cardiovascular death, in non-human primates. The drug candidate was developed at the University of Michigan.