Yuqing E Chen
Frederick G L Huetwell Professor of Cardiovascular Medicine
Professor of Internal Medicine
Professor of Surgery
Professor of Pharmacology
Professor of Molecular and Integrative Physiology
[email protected]

Available to mentor

Yuqing E Chen
  • About
  • Center Memberships
  • Recent Publications
  • About

    Dr. Chen is an expert in diabetes and cardiovascular disease. He cloned Exendin 4 (BYETTA), facilitating GLP1 drug development. He discovered the mechanisms of nitro-fatty acids, novel anti-inflammatory signaling molecules, currently in phase 2 clinical trials. Recently he embarked in successful integration of human genetic discoveries with translational research.

    Center Memberships
    • Center Member
      Center for Integrative Research in Critical Care
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Biosciences Initiative
    Recent Publications See All Publications
    • Journal Article
      XBP1-mediated transcriptional regulation of SLC5A1 in human epithelial cells in disease conditions.
      Sun Y, Zhang Y, Zhang J, Chen YE, Jin J-P, Zhang K, Mou H, Liang X, Xu J. Cell Biosci, 2024 Feb 22; 14 (1): 27 DOI:10.1186/s13578-024-01203-x
      PMID: 38388523
    • Journal Article
      Hepatic danger signaling triggers TREM2+ macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation.
      Zhou L, Qiu X, Meng Z, Liu T, Chen Z, Zhang P, Kuang H, Pan T, Lu Y, Qi L, Olson DP, Xu XZS, Chen YE, Li S, Lin JD. Sci Transl Med, 2024 Mar 13; 16 (738): eadk1866 DOI:10.1126/scitranslmed.adk1866
      PMID: 38478630
    • Journal Article
      Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD.
      Ghrayeb A, Finney AC, Agranovich B, Peled D, Anand SK, McKinney MP, Sarji M, Yang D, Weissman N, Drucker S, Fernandes SI, Fernández-García J, Mahan K, Abassi Z, Tan L, Lorenzi PL, Traylor J, Zhang J, Abramovich I, Chen YE, Rom O, Mor I, Gottlieb E. Cell Metab, 2024 Jan 2; 36 (1): 116 - 129.e7. DOI:10.1016/j.cmet.2023.12.013
      PMID: 38171331
    • Journal Article
      SWI/SNF Complex in Vascular Smooth Muscle Cells and Its Implications in Cardiovascular Pathologies.
      Liu H, Zhao Y, Zhao G, Deng Y, Chen YE, Zhang J. Cells, 2024 Jan 16; 13 (2): DOI:10.3390/cells13020168
      PMID: 38247859
    • Journal Article
      Sotagliflozin attenuates liver-associated disorders in cystic fibrosis rabbits.
      Liang X, Hou X, Bouhamdan M, Sun Y, Song Z, Rajagopalan C, Jiang H, Wei H-G, Song J, Yang D, Guo Y, Zhang Y, Mou H, Zhang J, Chen YE, Sun F, Jin J-P, Zhang K, Xu J. JCI Insight, 2024 Feb 15; 9 (6): DOI:10.1172/jci.insight.165826
      PMID: 38358827
    • Journal Article
      Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice.
      Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen YE, Han R. Cell Biosci, 2023 Jun 15; 13 (1): 109 DOI:10.1186/s13578-023-01036-0
      PMID: 37322547
    • Journal Article
      Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT-Expressing Smooth Muscle Cells.
      Mizrak D, Zhao Y, Feng H, Macaulay J, Tang Y, Sultan Z, Zhao G, Guo Y, Zhang J, Yang B, Chen YE. Arterioscler Thromb Vasc Biol, 2023 Dec; 43 (12): 2285 - 2297. DOI:10.1161/ATVBAHA.123.319329
      PMID: 37823268
    • Journal Article
      ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells.
      Tsai L-K, Peng M, Chang C-C, Wen L, Liu L, Liang X, Chen YE, Xu J, Sung L-Y. Cell Biosci, 2023 Oct 24; 13 (1): 193 DOI:10.1186/s13578-023-01140-1
      PMID: 37875990