1150 W. Medical Center Drive 3570 MSRB II
Ann Arbor, MI 48109
Available to mentor
Clinical Interests: asthma, bronchopulmonary dysplasia, chronic respiratory failure, congenital lung disease, cystic fibrosis. Dr. Hershenson is a board certified Pediatric Pulmonologist at The University of Michigan Medical School.
Hershenson Lab Marc Hershenson Mott Children's Hospital Profile Marc Hershenson Michigan Experts Profile Marc Hershenson PubMed Profile
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FellowshipThe Children's Hospital, Pediatrics, 1988
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FellowshipThe Children's Hospital, Pediatrics, 1988
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FellowshipThe Children's Hospital, Anesthesia, 1988
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ResidencyChildren's Memorial Hospital, Pediatrics, 1984
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InternChildren's Memorial Hospital, Pediatrics, 1982
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MDUniversity of Illinois College of Medicine, United States, 1981
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BSUniversity of Illinois at Urbana-Champaign, Urbana, 1977
Viral-induced asthma exacerbation, early-life viral infections in the development of asthma
The focus of my laboratory is respiratory viral infections, in particular rhinovirus infections. In addition to causing the "common cold," rhinovirus infections cause exacerbation of asthma, COPD and other chronic lung diseases. Early-life rhinovirus infections have also been associated with bronchiolitis and the development of asthma. Finally, we have studied other respiratory viruses including enterovirus-D68, which has been associated with a polio-like illness in children, and human coronavirus-NL63, a non-COVID coronavirus which causes common colds as well as pneumonia in vulnerable populations. Our work combines cell culture, animal models and human subjects research.
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Bentley JK, Kreger JE, Breckenridge HA, Singh S, Lei J, Li Y, Baker SC, Lumeng CN, Hershenson MB. Am J Physiol Lung Cell Mol Physiol, 2024 Oct 1; 327 (4): L557 - L573.Journal ArticleDeveloping a mouse model of human coronavirus NL63 infection: comparison with rhinovirus-A1B and effects of prior rhinovirus infection.
DOI:10.1152/ajplung.00149.2023 PMID: 39189801 -
Coughlin MA, Werner NL, Church JT, Perkins EM, Bryner BS, Barks JD, Bentley JK, Hershenson MB, Rabah R, Bartlett RH, Mychaliska GB. 2024 Jul 16; American Society for Artificial Internal Organs (ASAIO) Platinum 70th Anniversary Special Edition, 367 - 374.ChapterAn Artificial Placenta Protects Against Lung Injury and Promotes Continued Lung Development in Extremely Premature Lambs
DOI:10.1201/9781003543480-54 -
Sliwicki A, Essoh S, Kreger JE, Hershenson MB, Popova AP, Flori HR. 2024 May; a2246 - a2246.Proceeding / Abstract / PosterA Pilot Investigation of the Pediatric Host Inflammatory Response to Rhinovirus in Critical Bronchiolitis
DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2246 -
Kreger JE, Reiner MC, Ramsey AM, Hassan F, Filbrun AG, Hershenson MB. 2024 May; a6198 - a6198.Proceeding / Abstract / PosterInitiation of Home Positive Pressure Mechanical Ventilation at the University of Michigan C.S. Mott Children's Hospital, 2012-2022
DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a6198 -
Kreger JE, Essoh SN, Sliwicki AL, Jayachandran C, Czapla JA, Flori HR, Popova AP, Hershenson MB. 2024 May; a1290 - a1290.Proceeding / Abstract / PosterNasal Aspirate Cytokine Levels in Children Hospitalized With Rhinovirus A and Rhinovirus C Infections
DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a1290 -
Li Y, Singh S, Kreger J, Eberhardt E, Kuo S, Breckenridge H, Czapla J, Bentley JK, Horani A, Brody SL, Hershenson MB. 2024 May; a4336 - a4336.Proceeding / Abstract / PosterRhinovirus C15 Induces Epithelial Remodeling and Inflammatory Cytokine Expression: Implications for Asthma Exacerbation
DOI:10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4336 -
Li Y, Singh S, Breckenridge HA, Cui TX, Vigil TM, Kreger JE, Lei J, Wong HKA, Sajjakulnukit P, Zhou X, Kelley Bentley J, Lyssiotis CA, Mortensen RM, Hershenson MB. Mucosal Immunol, 2024 Aug 13;Journal ArticleItaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation.
DOI:10.1016/j.mucimm.2024.08.001 PMID: 39147278 -
Li Y, Han M, Singh S, Breckenridge HA, Kreger JE, Stroupe CC, Sawicky DA, Kuo S, Goldsmith AM, Ke F, Shenoy AT, Bentley JK, Matsumoto I, Hershenson MB. JCI Insight, 2024 Jan 23; 9 (2):Journal ArticleTuft cells are required for a rhinovirus-induced asthma phenotype in immature mice.
DOI:10.1172/jci.insight.166136 PMID: 38061015