Yatrik M Shah
Horace W Davenport Collegiate Professor of Physiology
Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
Program Director, Molecular and Integrative Physiology
Associate Director Academic Programs, Cancer Biology Graduate Program
[email protected]

Available to mentor
Yatrik M Shah
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    Dr. Shah received his PhD from the University of Toledo Health Science Center. After a postdoctoral fellowship at National Cancer Institute, he began his career as a principal investigator at the University of Michigan in 2010 in the Department of Molecular & Integrative Physiology and Internal Medicine, Division of Gastroenterology.

    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Precision Health Initiative
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Rogel Cancer Center
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    Research Overview

    Our laboratory studies changes in oxygen, metabolic waste products and nutrients from both systemic and cellular perspectives in the GI tract. Our interests lie in understanding how these factors coordinate proliferation and cell death during development, maintain functional tissues/organs, and how dysregulation culminate in disease. Our goal is to provide fundamental insights into how oxygen, metabolic waste products and nutrients are integrated into tissue and cellular metabolic homeostasis, and to understand precise mechanisms by which cellular dysregulation of these pathways impacts anemia, hemochromatosis, inflammation and cancer.

    Recent Publications See All Publications
    • Journal Article
      Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance.
      Solanki S, Sanchez K, Ponnusamy V, Kota V, Bell HN, Cho C-S, Kowalsky AH, Green M, Lee JH, Shah YM. Gastroenterology, 2023 Mar; 164 (3): 376 - 391.e13. DOI:10.1053/j.gastro.2022.11.014
      PMID: 36410445
    • Journal Article
      Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer.
      Bell HN, Huber AK, Singhal R, Korimerla N, Rebernick RJ, Kumar R, El-Derany MO, Sajjakulnukit P, Das NK, Kerk SA, Solanki S, James JG, Kim D, Zhang L, Chen B, Mehra R, Frankel TL, Győrffy B, Fearon ER, Pasca di Magliano M, Gonzalez FJ, Banerjee R, Wahl DR, Lyssiotis CA, Green M, Shah YM. Cell Metab, 2023 Jan 3; 35 (1): 134 - 149.e6. DOI:10.1016/j.cmet.2022.11.013
      PMID: 36528023
    • Journal Article
      Modulation of the HIF2α-NCOA4 axis in enterocytes attenuates iron loading in a mouse model of hemochromatosis.
      Das NK, Jain C, Sankar A, Schwartz AJ, Santana-Codina N, Solanki S, Zhang Z, Ma X, Parimi S, Rui L, Mancias JD, Shah YM. Blood, 2022 Apr 21; 139 (16): 2547 - 2552. DOI:10.1182/blood.2021013452
      PMID: 34990508
    • Journal Article
      Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance.
      Bell HN, Rebernick RJ, Goyert J, Singhal R, Kuljanin M, Kerk SA, Huang W, Das NK, Andren A, Solanki S, Miller SL, Todd PK, Fearon ER, Lyssiotis CA, Gygi SP, Mancias JD, Shah YM. Cancer Cell, 2022 Feb 14; 40 (2): 185 - 200.e6. DOI:10.1016/j.ccell.2021.12.001
      PMID: 34951957
    • Journal Article
      Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells.
      Schwartz AJ, Goyert JW, Solanki S, Kerk SA, Chen B, Castillo C, Hsu PP, Do BT, Singhal R, Dame MK, Lee H-J, Spence JR, Lakhal-Littleton S, Vander Heiden MG, Lyssiotis CA, Xue X, Shah YM. Nat Metab, 2021 Jul; 3 (7): 969 - 982. DOI:10.1038/s42255-021-00406-7
      PMID: 34155415
    • Journal Article
      HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron.
      Singhal R, Mitta SR, Das NK, Kerk SA, Sajjakulnukit P, Solanki S, Andren A, Kumar R, Olive KP, Banerjee R, Lyssiotis CA, Shah YM. J Clin Invest, 2021 Jun 15; 131 (12): DOI:10.1172/JCI143691
      PMID: 33914705
    • Journal Article
      Oxygen battle in the gut: Hypoxia and hypoxia-inducible factors in metabolic and inflammatory responses in the intestine.
      Singhal R, Shah YM. J Biol Chem, 2020 Jul 24; 295 (30): 10493 - 10505. DOI:10.1074/jbc.REV120.011188
      PMID: 32503843
    • Journal Article
      SLC4A11 mediates ammonia import and promotes cancer stemness in hepatocellular carcinoma.
      Elaimy AL, El-Derany MO, James J, Wang Z, Pearson AN, Holcomb EA, Huber AK, Gijón M, Bell HN, Sanghvi VR, Frankel TL, Su GL, Tapper EB, Tai AW, Ramnath N, Centonze CP, Dobrosotskaya I, Moeller JA, Bryant AK, Elliott DA, Choi E, Evans JR, Cuneo KC, Fitzgerald TJ, Wahl DR, Morgan MA, Chang DT, Wicha MS, Lawrence TS, Shah YM, Green MD. JCI Insight, 2024 Nov 8; 9 (21): DOI:10.1172/jci.insight.184826
      PMID: 39287988