1500 East Medical Center Drive
Ann Arbor, MI 48109
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Anna Suk-Fong Lok, M.D., is director of clinical hepatology and assistant dean for clinical research at the University of Michigan Medical School. She also is the Dame Sheila Sherlock Distinguished University Professor of Hepatology and Internal Medicine and Alice Lohrman Andrews Research Professor of Hepatology in the Department of Internal Medicine.
In her role as assistant dean, Dr. Lok is responsible for leading, championing, and implementing recommendations from the Research Board of Directors to transform the clinical trials enterprise of the academic medical center. She is responsible for the overall leadership and direction, management, and oversight of the Clinical Trials Support Units and the Clinical Research Unit, training of clinical investigators, and facilitation and support of clinical research.
Dr. Lok obtained her medical degree from the University of Hong Kong and her hepatology training under the late Dame Sheila Sherlock at the Royal Free Hospital in London, UK. She was on the faculty at the University of Hong Kong until she moved to the United States in 1992.
Her research focuses on the natural history and treatment of hepatitis B and C, and the prevention of liver cancer. Her research is funded by the National Institutes of Health, federal and private foundations, and various pharmaceutical companies. She has published more than 600 papers on viral hepatitis and liver diseases and is the co-author of five editions of the American Association for the Study of Liver Diseases Association Guidelines on Hepatitis B. She was one of the top 1% most cited scientists in the world for the decade 2002-12. She has trained more than 60 fellows and junior faculty from all over the world, some of whom have risen to the ranks of full professors and directors of liver programs in their home country. She received a Distinguished Mentor Award from the Michigan Institute of Clinical and Health Research in 2012, an Inspirational Physician Award from the American Medical Association in 2014, and a Distinguished Mentor Award from the American Gastroenterological Association in 2022. She was inducted into the Clinical Excellence Society in the Department of Internal Medicine in 2013.
Dr. Lok has received many awards throughout her career. She has been included in the list of “Best Doctors” and “Who's Who” for many years. She was inducted into the Association of American Physicians in 2012 and elected to the National Academy of Medicine in 2022. Recent awards include the Distinguished Scientist Award from the Hepatitis B Foundation in 2008, the Distinguished Women Scientist Award from the American Gastroenterological Association in 2008, the Distinguished Service Award from the American Association for the Study of Liver Diseases in 2011, the Distinguished Scientific Achievement Award from the American Liver Foundation in 2015, the William Beaumont Prize in Gastroenterology from the American Gastroenterological Association in 2016, a Gold Medal Award from the Canadian Association for the Study of the Liver and an honorary Doctor of Science degree from the University of Hong Kong in 2017, the International Recognition Award from the European Association of the Study of the Liver in 2018, and a Distinguished University Professorship from the University of Michigan in 2019.
She is currently an associate editor of Hepatology Communication. She was an associate editor of HEPATOLOGY from 2001-06, a co-editor of the Journal of Viral Hepatitis from 2007-09, and a senior associate editor of GASTROENTEROLOGY from 2011-12.
Dr. Lok was the President of the American Association for the Study of Liver Diseases in 2017.
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MDUniversity of Hong Kong, Hong Kong, 1990
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MB BSUniversity of Hong Kong School of Medicine, Hong Kong, 1977
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Center MemberRogel Cancer Center
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Center MemberInstitute for Healthcare Policy and Innovation
Epidemiology, natural history, and treatment of hepatitis B and C
Risk stratification of nonalcoholic fatty liver disease
Prevention and early detection of hepatocellular carcinoma
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Gairing SJ, Mangini C, Zarantonello L, Gioia S, Nielsen EJ, Danneberg S, Lok AS, Sultanik P, Galle PR, Labenz J, Thabut D, Marquardt JU, Bloom PP, Lauridsen MM, Montagnese S, Nardelli S, Labenz C. J Intern Med, 2024 Mar; 295 (3): 331 - 345.Journal ArticleMinimal hepatic encephalopathy is associated with a higher risk of overt hepatic encephalopathy and poorer survival.
DOI:10.1111/joim.13747 PMID: 37983845 -
Lok ASF. Gut Liver, 2024 Mar 27;Journal ArticleToward a Functional Cure for Hepatitis B.
DOI:10.5009/gnl240023 PMID: 38533651 -
Gairing SJ, Mangini C, Zarantonello L, Gioia S, Nielsen EJ, Danneberg S, Gabriel M, Ehrenbauer AF, Bloom PP, Ripoll C, Sultanik P, Galle PR, Labenz J, Thabut D, Zipprich A, Lok AS, Weissenborn K, Marquardt JU, Lauridsen MM, Nardelli S, Montagnese S, Labenz C. Am J Gastroenterol, 2023 Dec 1; 118 (12): 2191 - 2200.Journal ArticlePrevalence of Minimal Hepatic Encephalopathy in Patients With Liver Cirrhosis: A Multicenter Study.
DOI:10.14309/ajg.0000000000002251 PMID: 36940426 -
Perrillo R, Lok AS, Leonard K, Ghany MG, Terrault N, Belle SH, Janssen HLA, Hepatitis B Research Network . Am J Gastroenterol, 2023 Nov 1; 118 (11): 2075 - 2079.Journal ArticleAssociation of Alanine Aminotransferase Flares to Hepatitis B Surface Decline During Tenofovir Alone or With Pegylated Interferon Alfa.
DOI:10.14309/ajg.0000000000002355 PMID: 37307571 -
Ghany MG, King WC, Hinerman AS, Lok AS, Lisker-Melman M, Chung RT, Terrault N, Janssen HLA, Khalili M, Lee WM, Lau DTY, Cloherty GA, Sterling RK. Hepatology, 2023 Nov 1; 78 (5): 1542 - 1557.Journal ArticleUse of HBV RNA and to predict change in serological status and disease activity in CHB.
DOI:10.1097/HEP.0000000000000413 PMID: 37074026 -
Mellinger JL, Medley S, Kidwell KM, Asefah H, Winder GS, Fernandez AC, Lok ASF, Blow F. Hepatol Commun, 2023 Oct 1; 7 (10):Journal ArticleImproving alcohol treatment engagement using integrated behavioral interventions in alcohol-associated liver disease: A randomized pilot trial.
DOI:10.1097/HC9.0000000000000181 PMID: 37708435 -
Kim 金雄來 WR, Iwakiri 岩切泰子 Y, Lok 駱淑芳 ASF. Hepatology, 2023 Oct 1; 78 (4): 1032 - 1034.Journal ArticleWhat is in a name? Toward culturally sensitive nomenclature for liver disease in the east and west.
DOI:10.1097/HEP.0000000000000410 PMID: 37070237 -
Bloom PP, Fisher C, Otajonova N, Garrido L, Farrell A, Robin J, Asrani S, Lok AS. The American Journal of Gastroenterology, 2023 Sep; 118 (9S): s2 - s3.Journal ArticleP4 HE Audio Recording to Detect Minimal Hepatic Encephalopathy (“HEAR-MHE”) Study: Speech Identifies Minimal Hepatic Encephalopathy
DOI:10.14309/01.ajg.0000948296.56025.07