Yan Zhang
Assistant Professor of Biological Chemistry
[email protected]

Available to mentor

Yan Zhang
Assistant Professor
  • Research Overview
  • Links
  • Recent Publications
  • Research Overview

    The overarching goal of my lab is (i) to decipher the fascinating biology of diverse CRISPR-Cas systems in bacteria, and (ii) to convert their novel features into new biotechnologies and gene therapy strategies for treating human diseases. We use a multidisciplinary approach blending cell biology, genetics, biochemistry, next-generation sequencing, bioinformatics, and animal models to uncover brand-new CRISPR systems from nature, invent gene-editing tools, and leverage CRISPR therapeutics to tackle a wide range of genetic disorders.

    Links
    • https://yanzhanglab.med.umich.edu/
    Recent Publications See All Publications
    • Journal Article
      Development and implementation of a Type I-C CRISPR-based programmable repression system for Neisseria gonorrhoeae.
      Geslewitz WE, Cardenas A, Zhou X, Zhang Y, Criss AK, Seifert HS. mBio, 2024 Feb 14; 15 (2): e0302523 DOI:10.1128/mbio.03025-23
      PMID: 38126782
    • Journal Article
      Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications.
      Hu C, Myers MT, Zhou X, Hou Z, Lozen ML, Nam KH, Zhang Y, Ke A. Mol Cell, 2024 Feb 1; 84 (3): 463 - 475.e5. DOI:10.1016/j.molcel.2023.12.034
      PMID: 38242128
    • Journal Article
      Snapshots of a tiny ancestral nuclease of Cas9.
      Hou Z, Tan R, Zhang Y. Trends Biochem Sci, 2023 Jan; 48 (1): 9 - 10. DOI:10.1016/j.tibs.2022.08.008
      PMID: 36100522
    • Journal Article
      Cas11 enables genome engineering in human cells with compact CRISPR-Cas3 systems.
      Tan R, Krueger RK, Gramelspacher MJ, Zhou X, Xiao Y, Ke A, Hou Z, Zhang Y. Mol Cell, 2022 Feb 17; 82 (4): 852 - 867.e5. DOI:10.1016/j.molcel.2021.12.032
      PMID: 35051351
    • Journal Article
      Introducing Large Genomic Deletions in Human Pluripotent Stem Cells Using CRISPR-Cas3.
      Hou Z, Hu C, Ke A, Zhang Y. Curr Protoc, 2022 Feb; 2 (2): e361 DOI:10.1002/cpz1.361
      PMID: 35129865
    • Journal Article
      Biochemical characterization of RNA-guided ribonuclease activities for CRISPR-Cas9 systems.
      Gramelspacher MJ, Hou Z, Zhang Y. Methods, 2020 Feb 1; 172: 32 - 41. DOI:10.1016/j.ymeth.2019.06.018
      PMID: 31228550
    • Journal Article
      Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas.
      Dolan AE, Hou Z, Xiao Y, Gramelspacher MJ, Heo J, Howden SE, Freddolino PL, Ke A, Zhang Y. Mol Cell, 2019 Jun 6; 74 (5): 936 - 950.e5. DOI:10.1016/j.molcel.2019.03.014
      PMID: 30975459
    • Journal Article
      Inserting DNA with CRISPR.
      Hou Z, Zhang Y. Science, 2019 Jul 5; 365 (6448): 25 - 26. DOI:10.1126/science.aay2056
      PMID: 31273110
    Featured News & Stories
    Department News
    PhD student Mason Myers is a lead author of a research article in Molecular Cell
    PhD student Mason Myers of the Zhang lab at U-M Medical School is a lead author of "Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications."
    Department News
    Yan Zhang lab receives Research Scouts Award for collaborative project
    Yan Zhang lab receives Research Scouts Award for collaborative project