Gregory Clines, MD, PhD
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About
Dr. Gregory Clines is an Associate Professor of Internal Medicine and Chief of the Division of Metabolism, Endocrinology & Diabetes (MEND) at the University of Michigan. He received MD and PhD degrees at the University of Texas Southwestern Medical Center at Dallas. He then completed internal medicine training at Duke University and an endocrinology fellowship at the University of Virginia. Before joining the University of Michigan in 2013, he was on the faculty at the University of Virginia and the University of Alabama at Birmingham.
Dr. Clines has been studying and thinking about bone diseases for nearly 30 years. His basic science laboratory studies how novel factors such as hypoxia, androgens, endothelins, Wnt signaling, and other factors regulate the osteoblast-cancer cell synergy in bone metastasis. His other research interests include understanding how sex steroids regulate skeletal size and shape and the development of novel imaging techniques to assess bone quality.
His clinical interests include metabolic and genetic bone diseases as well as general endocrinology. Dr. Clines sees patients at the Metabolism, Endocrinology & Diabetes Clinic (Metabolic Bone Disease Clinic) and at the Ann Arbor Veterans Affairs Medical Center.
Qualifications
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Endocrinology FellowshipUniversity of Virginia, Internal Medicine, Charlottesville, United States
2002 - 2005
Postdoctoral Fellowship
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ResidentDuke University, Internal Medicine, Durham, United States
2000 - 2002
Residency
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InternshipDuke University, Internal Medicine, Durham, United States
1999 - 2000
Internship
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PhD, Genetics and DevelopmentThe University of Texas Southwestern Medical Center at Dallas, Southwestern Graduate School of Biomedical Sciences, Dallas, TX, Texas, United States
1991 - 1999
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MDThe University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., Dallas, TX, Texas, 75390-9003, United States
1991 - 1999
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BS, Biology (with honors)The University of Texas at Arlington, Arlington, TX, Texas, United States
1985 - 1990
Center Memberships
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Center MemberBiosciences Initiative
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Center MemberCaswell Diabetes Institute
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Center MemberCenter for Cell Plasticity and Organ Design
Recent Publications
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Abdul Kather F, Esfandiari NH, Clines G, Janney CA, Hughes D, Saberi, MD S. Endocrine Practice, 2025 Dec 12; 32 (4): 565 - 569.Journal ArticlePost-parathyroidectomy bone density changes in patients with biochemically mild primary hyperparathyroidism
DOI:10.1016/j.eprac.2025.11.019 -
Leis AM, Jepsen KJ, Bigelow E, Goulet RW, Clines GA, Richards-McCullough K, Cho Y, Richards TR, Karvonen-Gutierrez CA. Journal of Bone and Mineral Research, 2026 Apr 1; 41 (4): 415 - 423.Journal ArticleTrajectories of areal bone mineral density significantly differ by patterning of femoral neck area and bone mineral content across the menopausal transition
DOI:10.1093/jbmr/zjaf162 PMID: 41230819 -
Khurram D, Kupkova K, Mesner LD, Kraftson AT, Farber CR, Clines GA. JCEM Case Rep, 2026 Sep 19; 3 (12): luaf239 - luaf239.Journal ArticleOsteoporosis Associated with SCN8A Mutation.
DOI:10.1210/jcemcr/luaf239 -
Jepsen KJ, Bredbenner TL, Karvonen-Gutierrez CA, Leis AM, Hood MM, Harlow SD, Randolph J, Clines GA, Merillat S, Elliott MR, Cauley JA, Greendale GA, Karlamangla AS, Peters KW, Harrison SL, Lui LY, Cawthon PM, Orwoll E. Journal of Bone and Mineral Research, 2025 Oct 1; 40 (10): 1114 - 1126.Journal ArticleFemoral neck width is associated with unique trajectories of age-related hip structural changes and fracture risk within populations of adult women and men
DOI:10.1093/jbmr/zjaf090 PMID: 40580057 -
Sonmez Ince M, Esfandiari N, Hussain MA, Haymart M, Thakker RV, Clines G. 2025 Jun 15;Proceeding / Abstract / PosterRefractory Hypocalcemia from Combined Autosomal Dominant Hypocalcemia Type 2 And Postsurgical Hypoparathyroidism
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Kather FA, Clines GA, Janney C, Hughes DT, Esfandiari NH, Saberi S. Journal of the Endocrine Society, 2024 Oct 7; 8 (Supplement_1): bvae163.445Journal Article6722 Increase in Femoral Neck BMD After Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism
DOI:10.1210/jendso/bvae163.445 PMID: PMC11454277 -
Khurram D, Kraftson A, Clines G. 2024 Sep 29;Proceeding / Abstract / PosterOsteoporosis associated with SCN8A mutation
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Grigoryan S, Clines GA. Endocrine Practice, 2024 Jul 1; 30 (7): 687 - 694.Journal ArticleHormonal Control of Bone Architecture Throughout the Lifespan: Implications for Fracture Prediction and Prevention
DOI:10.1016/j.eprac.2024.04.006 PMID: 38631489