Available to mentor
Dr. Gregory Clines is an Associate Professor of Internal Medicine and Chief (interim) of the Division of Metabolism, Endocrinology & Diabetes (MEND) at the University of Michigan. He received MD and PhD degrees at the University of Texas Southwestern Medical Center at Dallas. He then completed internal medicine training at Duke University and an endocrinology fellowship at the University of Virginia. Before joining the University of Michigan in 2013, he was on the faculty at the University of Virginia and the University of Alabama at Birmingham.
Dr. Clines has been studying and thinking about bone diseases for nearly 30 years. His basic science laboratory studies how novel factors such as hypoxia, androgens, endothelins, Wnt signaling, and other factors regulate the osteoblast-cancer cell synergy in bone metastasis. His other research interests include understanding how sex steroids regulate skeletal size and shape and the development of novel imaging techniques to assess bone quality.
His clinical interests include metabolic and genetic bone diseases as well as general endocrinology. Dr. Clines sees patients at the Metabolism, Endocrinology & Diabetes Clinic (Metabolic Bone Disease Clinic) and at the Ann Arbor Veterans Affairs Medical Center.
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Endocrinology FellowshipUniversity of Virginia, Internal Medicine, 2005
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ResidentDuke University, Internal Medicine, 2002
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InternshipDuke University, Internal Medicine, 2000
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PhD, Genetics and DevelopmentThe University of Texas Southwestern Medical Center at Dallas, Southwestern Graduate School of Biomedical Sciences, Dallas, TX, 1999
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MDThe University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 1999
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BS, Biology (with honors)The University of Texas at Arlington, Arlington, TX, 1990
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Center MemberBiosciences Initiative
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Center MemberCenter for Cell Plasticity and Organ Design
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Grigoryan S, Clines GA. Endocr Pract, 2024 Apr 16;Journal ArticleHormonal Control of Bone Architecture Throughout the Lifespan: Implications for Fracture Prediction and Prevention.
DOI:10.1016/j.eprac.2024.04.006 PMID: 38631489 -
Clines KL, Moon HH, Clines GA. Journal of Bone Oncology, 2024 Apr; 45: 100563Journal Article#25. Regulation of osteoblast migration, secretome, and metabolic programming by prostate cancer
DOI:10.1016/j.jbo.2024.100563 -
Jepsen KJ, Bigelow EMR, Goulet RW, Nolan BT, Casden MA, Kennedy K, Hertz S, Kadur C, Clines GA, Leis AM, Karvonen-Gutierrez CA, Bredbenner TL. JBMR Plus, 2024 Apr; 8 (4): ziae013Journal ArticleStructural differences contributing to sex-specific associations between FN BMD and whole-bone strength for adult White women and men.
DOI:10.1093/jbmrpl/ziae013 PMID: 38523663 -
Chen Z, Akanbi F, Lucas DR, Walton DM, Benavides E, Soki FN, Siegel GW, McCauley LK, Clines GA. J Bone Miner Res, 2024 Mar 22; 39 (2): 79 - 84.Journal ArticleA skeleton in a huff: insights in etiologies of osteosclerosis.
DOI:10.1093/jbmr/zjad021 PMID: 38477819 -
Ince MS, Hannan F, Esfandiari NH, Hussain MA, Haymart MR, Thakker RV, Clines GA. Journal of the Endocrine Society, 2023 Oct 5; 7 (Supplement_1): bvad114.515Proceeding / Abstract / PosterSAT218 Refractory Hypocalcemia From Combined Autosomal Dominant Hypocalcemia Type 2 And Postsurgical Hypoparathyroidism
DOI:10.1210/jendso/bvad114.515 -
Whitney DG, Caird MS, Raggio CL, Hurvitz EA, Clines GA, Jepsen KJ. Bone, 2023 Oct; 175: 116855Journal ArticlePerspective: A multi-trait integrative approach to understanding the structural basis of bone fragility for pediatric conditions associated with abnormal bone development.
DOI:10.1016/j.bone.2023.116855 PMID: 37481149 -
Jepsen KJ, Bigelow EM, Casden MA, Goulet RW, Kennedy K, Hertz S, Kadur C, Nolan BT, Richards-McCullough K, Merillat S, Karvonen-Gutierrez CA, Clines G, Bredbenner TL. JBMR Plus, 2023 Mar; 7 (3): e10715Journal ArticleAssociations Among Hip Structure, Bone Mineral Density, and Strength Vary With External Bone Size in White Women.
DOI:10.1002/jbm4.10715 PMID: 36936363 -
El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, Van Poznak C, Wu JY, Drake MT. J Clin Endocrinol Metab, 2023 Feb 15; 108 (3): 507 - 528.Journal ArticleTreatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.
DOI:10.1210/clinem/dgac621 PMID: 36545746