Gregory A Clines
Associate Professor of Internal Medicine and Interim Section Head
Division of Metabolism
Endocrinology
Diabetes
[email protected]

Available to mentor

Gregory A Clines
Associate Professor
  • About
  • Qualifications
  • Center Memberships
  • Recent Publications
  • About

    Dr. Gregory Clines is an Associate Professor of Internal Medicine and Chief (interim) of the Division of Metabolism, Endocrinology & Diabetes (MEND) at the University of Michigan. He received MD and PhD degrees at the University of Texas Southwestern Medical Center at Dallas. He then completed internal medicine training at Duke University and an endocrinology fellowship at the University of Virginia. Before joining the University of Michigan in 2013, he was on the faculty at the University of Virginia and the University of Alabama at Birmingham.

    Dr. Clines has been studying and thinking about bone diseases for nearly 30 years. His basic science laboratory studies how novel factors such as hypoxia, androgens, endothelins, Wnt signaling, and other factors regulate the osteoblast-cancer cell synergy in bone metastasis. His other research interests include understanding how sex steroids regulate skeletal size and shape and the development of novel imaging techniques to assess bone quality.

    His clinical interests include metabolic and genetic bone diseases as well as general endocrinology. Dr. Clines sees patients at the Metabolism, Endocrinology & Diabetes Clinic (Metabolic Bone Disease Clinic) and at the Ann Arbor Veterans Affairs Medical Center.

    Qualifications
    • Endocrinology Fellowship
      University of Virginia, Internal Medicine, 2005
    • Resident
      Duke University, Internal Medicine, 2002
    • Internship
      Duke University, Internal Medicine, 2000
    • PhD, Genetics and Development
      The University of Texas Southwestern Medical Center at Dallas, Southwestern Graduate School of Biomedical Sciences, Dallas, TX, 1999
    • MD
      The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd., 1999
    • BS, Biology (with honors)
      The University of Texas at Arlington, Arlington, TX, 1990
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design
    Recent Publications See All Publications
    • Journal Article
      Hormonal Control of Bone Architecture Throughout the Lifespan: Implications for Fracture Prediction and Prevention.
      Grigoryan S, Clines GA. Endocr Pract, 2024 Apr 16; DOI:10.1016/j.eprac.2024.04.006
      PMID: 38631489
    • Journal Article
      #25. Regulation of osteoblast migration, secretome, and metabolic programming by prostate cancer
      Clines KL, Moon HH, Clines GA. Journal of Bone Oncology, 2024 Apr; 45: 100563 DOI:10.1016/j.jbo.2024.100563
    • Journal Article
      Structural differences contributing to sex-specific associations between FN BMD and whole-bone strength for adult White women and men.
      Jepsen KJ, Bigelow EMR, Goulet RW, Nolan BT, Casden MA, Kennedy K, Hertz S, Kadur C, Clines GA, Leis AM, Karvonen-Gutierrez CA, Bredbenner TL. JBMR Plus, 2024 Apr; 8 (4): ziae013 DOI:10.1093/jbmrpl/ziae013
      PMID: 38523663
    • Journal Article
      A skeleton in a huff: insights in etiologies of osteosclerosis.
      Chen Z, Akanbi F, Lucas DR, Walton DM, Benavides E, Soki FN, Siegel GW, McCauley LK, Clines GA. J Bone Miner Res, 2024 Mar 22; 39 (2): 79 - 84. DOI:10.1093/jbmr/zjad021
      PMID: 38477819
    • Proceeding / Abstract / Poster
      SAT218 Refractory Hypocalcemia From Combined Autosomal Dominant Hypocalcemia Type 2 And Postsurgical Hypoparathyroidism
      Ince MS, Hannan F, Esfandiari NH, Hussain MA, Haymart MR, Thakker RV, Clines GA. Journal of the Endocrine Society, 2023 Oct 5; 7 (Supplement_1): bvad114.515 DOI:10.1210/jendso/bvad114.515
    • Journal Article
      Perspective: A multi-trait integrative approach to understanding the structural basis of bone fragility for pediatric conditions associated with abnormal bone development.
      Whitney DG, Caird MS, Raggio CL, Hurvitz EA, Clines GA, Jepsen KJ. Bone, 2023 Oct; 175: 116855 DOI:10.1016/j.bone.2023.116855
      PMID: 37481149
    • Journal Article
      Associations Among Hip Structure, Bone Mineral Density, and Strength Vary With External Bone Size in White Women.
      Jepsen KJ, Bigelow EM, Casden MA, Goulet RW, Kennedy K, Hertz S, Kadur C, Nolan BT, Richards-McCullough K, Merillat S, Karvonen-Gutierrez CA, Clines G, Bredbenner TL. JBMR Plus, 2023 Mar; 7 (3): e10715 DOI:10.1002/jbm4.10715
      PMID: 36936363
    • Journal Article
      Treatment of Hypercalcemia of Malignancy in Adults: An Endocrine Society Clinical Practice Guideline.
      El-Hajj Fuleihan G, Clines GA, Hu MI, Marcocci C, Murad MH, Piggott T, Van Poznak C, Wu JY, Drake MT. J Clin Endocrinol Metab, 2023 Feb 15; 108 (3): 507 - 528. DOI:10.1210/clinem/dgac621
      PMID: 36545746