Gregory Clines, MD, PhD
Associate Professor of Internal Medicine
Interim Section Head, Division of Metabolism, Endocrinology, and Diabetes
Medical School

Available to mentor

Gregory Clines, MD, PhD
Associate Professor
  • About
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  • Center Memberships
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    About

    Dr. Gregory Clines is an Associate Professor of Internal Medicine and Chief (interim) of the Division of Metabolism, Endocrinology & Diabetes (MEND) at the University of Michigan. He received MD and PhD degrees at the University of Texas Southwestern Medical Center at Dallas. He then completed internal medicine training at Duke University and an endocrinology fellowship at the University of Virginia. Before joining the University of Michigan in 2013, he was on the faculty at the University of Virginia and the University of Alabama at Birmingham.

    Dr. Clines has been studying and thinking about bone diseases for nearly 30 years. His basic science laboratory studies how novel factors such as hypoxia, androgens, endothelins, Wnt signaling, and other factors regulate the osteoblast-cancer cell synergy in bone metastasis. His other research interests include understanding how sex steroids regulate skeletal size and shape and the development of novel imaging techniques to assess bone quality.

    His clinical interests include metabolic and genetic bone diseases as well as general endocrinology. Dr. Clines sees patients at the Metabolism, Endocrinology & Diabetes Clinic (Metabolic Bone Disease Clinic) and at the Ann Arbor Veterans Affairs Medical Center.

    Qualifications
    • Endocrinology Fellowship
      University of Virginia, Internal Medicine, 2005
    • Resident
      Duke University, Internal Medicine, 2002
    • Internship
      Duke University, Internal Medicine, 2000
    • PhD, Genetics and Development
      The University of Texas Southwestern Medical Center at Dallas, Southwestern Graduate School of Biomedical Sciences, 1999
    • MD
      The University of Texas Southwestern Medical Center at Dallas, 1999
    • BS, Biology (with honors)
      The University of Texas at Arlington, 1990
    Center Memberships
    • Center Member
      Biosciences Initiative
    • Center Member
      Center for Cell Plasticity and Organ Design
    Recent Publications See All Publications
    • Journal Article
      Femoral neck width is associated with unique trajectories of age-related hip structural changes and fracture risk within populations of adult women and men.
      Jepsen KJ, Bredbenner TL, Karvonen-Gutierrez CA, Leis AM, Hood MM, Harlow SD, Randolph J, Clines GA, Merillat S, Elliott MR, Cauley JA, Greendale GA, Karlamangla AS, Peters KW, Harrison SL, Lui L-Y, Cawthon PM, Orwoll E. J Bone Miner Res, 2025 Jun 28; DOI:10.1093/jbmr/zjaf090
      PMID: 40580057
    • Journal Article
      6722 Increase in Femoral Neck BMD After Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism
      Kather FA, Clines GA, Janney C, Hughes DT, Esfandiari NH, Saberi S. Journal of the Endocrine Society, 2024 Oct 7; 8 (Supplement_1): bvae163.445 DOI:10.1210/jendso/bvae163.445
      PMID: PMC11454277
    • Proceeding / Abstract / Poster
      Osteoporosis associated with SCN8A mutation
      Khurram D, Kraftson A, Clines G. 2024 Sep 29;
    • Journal Article
      Hormonal Control of Bone Architecture Throughout the Lifespan: Implications for Fracture Prediction and Prevention
      Grigoryan S, Clines GA. Endocrine Practice, 2024 Jul 1; 30 (7): 687 - 694. DOI:10.1016/j.eprac.2024.04.006
      PMID: 38631489
    • Proceeding / Abstract / Poster
      Increase in Femoral Neck BMD After Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism
      Abdul Kather F, Clines G, Janney C, Hughes D, Esfandiari N, Saberi S. 2024 Jun 1;
    • Journal Article
      #25. Regulation of osteoblast migration, secretome, and metabolic programming by prostate cancer
      Clines KL, Moon HH, Clines GA. Journal of Bone Oncology, 2024 Apr 25; 45: 100563 DOI:10.1016/j.jbo.2024.100563
    • Journal Article
      Structural differences contributing to sex-specific associations between FN BMD and whole-bone strength for adult White women and men
      Jepsen KJ, Bigelow EMR, Goulet RW, Nolan BT, Casden MA, Kennedy K, Hertz S, Kadur C, Clines GA, Leis AM, Karvonen-Gutierrez CA, Bredbenner TL. JBMR Plus, 2024 Apr 1; 8 (4): DOI:10.1093/jbmrpl/ziae013
    • Journal Article
      A skeleton in a huff: insights in etiologies of osteosclerosis
      Chen Z, Akanbi F, Lucas DR, Walton DM, Benavides E, Soki FN, Siegel GW, McCauley LK, Clines GA. Journal of Bone and Mineral Research, 2024 Feb 1; 39 (2): 79 - 84. DOI:10.1093/jbmr/zjad021
      PMID: 38477819