
Available to mentor

Dr. Gregory Clines is an Associate Professor of Internal Medicine and Chief (interim) of the Division of Metabolism, Endocrinology & Diabetes (MEND) at the University of Michigan. He received MD and PhD degrees at the University of Texas Southwestern Medical Center at Dallas. He then completed internal medicine training at Duke University and an endocrinology fellowship at the University of Virginia. Before joining the University of Michigan in 2013, he was on the faculty at the University of Virginia and the University of Alabama at Birmingham.
Dr. Clines has been studying and thinking about bone diseases for nearly 30 years. His basic science laboratory studies how novel factors such as hypoxia, androgens, endothelins, Wnt signaling, and other factors regulate the osteoblast-cancer cell synergy in bone metastasis. His other research interests include understanding how sex steroids regulate skeletal size and shape and the development of novel imaging techniques to assess bone quality.
His clinical interests include metabolic and genetic bone diseases as well as general endocrinology. Dr. Clines sees patients at the Metabolism, Endocrinology & Diabetes Clinic (Metabolic Bone Disease Clinic) and at the Ann Arbor Veterans Affairs Medical Center.
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Endocrinology FellowshipUniversity of Virginia, Internal Medicine, 2005
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ResidentDuke University, Internal Medicine, 2002
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InternshipDuke University, Internal Medicine, 2000
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PhD, Genetics and DevelopmentThe University of Texas Southwestern Medical Center at Dallas, Southwestern Graduate School of Biomedical Sciences, 1999
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MDThe University of Texas Southwestern Medical Center at Dallas, 1999
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BS, Biology (with honors)The University of Texas at Arlington, 1990
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Center MemberBiosciences Initiative
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Center MemberCenter for Cell Plasticity and Organ Design
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Jepsen KJ, Bredbenner TL, Karvonen-Gutierrez CA, Leis AM, Hood MM, Harlow SD, Randolph J, Clines GA, Merillat S, Elliott MR, Cauley JA, Greendale GA, Karlamangla AS, Peters KW, Harrison SL, Lui L-Y, Cawthon PM, Orwoll E. J Bone Miner Res, 2025 Jun 28;Journal ArticleFemoral neck width is associated with unique trajectories of age-related hip structural changes and fracture risk within populations of adult women and men.
DOI:10.1093/jbmr/zjaf090 PMID: 40580057 -
Kather FA, Clines GA, Janney C, Hughes DT, Esfandiari NH, Saberi S. Journal of the Endocrine Society, 2024 Oct 7; 8 (Supplement_1): bvae163.445Journal Article6722 Increase in Femoral Neck BMD After Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism
DOI:10.1210/jendso/bvae163.445 PMID: PMC11454277 -
Khurram D, Kraftson A, Clines G. 2024 Sep 29;Proceeding / Abstract / PosterOsteoporosis associated with SCN8A mutation
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Grigoryan S, Clines GA. Endocrine Practice, 2024 Jul 1; 30 (7): 687 - 694.Journal ArticleHormonal Control of Bone Architecture Throughout the Lifespan: Implications for Fracture Prediction and Prevention
DOI:10.1016/j.eprac.2024.04.006 PMID: 38631489 -
Abdul Kather F, Clines G, Janney C, Hughes D, Esfandiari N, Saberi S. 2024 Jun 1;Proceeding / Abstract / PosterIncrease in Femoral Neck BMD After Parathyroidectomy in Patients with Mild Primary Hyperparathyroidism
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Clines KL, Moon HH, Clines GA. Journal of Bone Oncology, 2024 Apr 25; 45: 100563Journal Article#25. Regulation of osteoblast migration, secretome, and metabolic programming by prostate cancer
DOI:10.1016/j.jbo.2024.100563 -
Jepsen KJ, Bigelow EMR, Goulet RW, Nolan BT, Casden MA, Kennedy K, Hertz S, Kadur C, Clines GA, Leis AM, Karvonen-Gutierrez CA, Bredbenner TL. JBMR Plus, 2024 Apr 1; 8 (4):Journal ArticleStructural differences contributing to sex-specific associations between FN BMD and whole-bone strength for adult White women and men
DOI:10.1093/jbmrpl/ziae013 -
Chen Z, Akanbi F, Lucas DR, Walton DM, Benavides E, Soki FN, Siegel GW, McCauley LK, Clines GA. Journal of Bone and Mineral Research, 2024 Feb 1; 39 (2): 79 - 84.Journal ArticleA skeleton in a huff: insights in etiologies of osteosclerosis
DOI:10.1093/jbmr/zjad021 PMID: 38477819