Costas A Lyssiotis, PhD
Maisel Research Professor of Oncology
Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
Director Academic Program
Office of Graduate and Postdoctoral Studies
Co-Director of Pancreas Cancer Initiatives
Rogel Cancer Center
1150 E. Medical Center Drive
Ann Arbor
Michigan, 48109-5942 United States
[email protected]

Available to mentor

Costas A Lyssiotis, PhD
Professor
  • About
  • Links
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Prof. Lyssiotis obtained his bachelor’s degree in Chemistry and Biochemistry from the University of Michigan in 2004, his PhD in Chemical Biology from The Scripps Research Institute in 2010, and then completed postdoctoral training in the laboratory of Lewis C. Cantley at Harvard and Cornell. In 2015, Prof. Lyssiotis joined the faculty at the University of Michigan with appointments in the Departments of Physiology and Medicine. His lab studies the biochemical pathways and metabolic requirements that enable tumor survival and growth. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, his group aims to transition new information about these processes into targeted therapies for cancer and other diseases. He is the recipient of several junior scholar awards including being named a Lefkofsky Scholar, a Kimmel Scholar, an AACR NextGen young investigator, a Dale F. Frey Breakthrough Scientist, and a V Foundation Fellow.

    Links
    • Lyssiotis Lab
    Center Memberships
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      MM-PKUHSC Joint Institute
    • Center Member
      Rogel Cancer Center
    • Center Member
      Global REACH
    Research Overview

    Tumor Metabolism, Cancer Biochemistry, Immunometabolism, Tumor Microenvironment, Pancreatic Cancer, Metabolomics, Immunotherapy, Cancer-Diet Interactions, Diffuse Intrinsic Pontine Glioma (DIPG)

    Recent Publications See All Publications
    • Journal Article
      Uridine-derived ribose fuels glucose-restricted pancreatic cancer.
      Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee H-J, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. Nature, 2023 Jun; 618 (7963): 151 - 158. DOI:10.1038/s41586-023-06073-w
      PMID: 37198494
    • Journal Article
      Pancreatic cancer: Advances and challenges.
      Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Cell, 2023 Apr 13; 186 (8): 1729 - 1754. DOI:10.1016/j.cell.2023.02.014
      PMID: 37059070
    • Journal Article
      OXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment.
      Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. Sci Immunol, 2022 Nov 25; 7 (77): eabm8182 DOI:10.1126/sciimmunol.abm8182
      PMID: 36399539
    • Journal Article
      Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.
      Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Nat Cancer, 2022 Nov; 3 (11): 1386 - 1403. DOI:10.1038/s43018-022-00463-1
      PMID: 36411320
    • Journal Article
      Metabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
      Kerk SA, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, Hoffman MT, Wen H-J, Long D, Ackenhusen SE, Ramos J, Gao X, Nwosu ZC, Galban S, Halbrook CJ, Lombard DB, Piwnica-Worms DR, Ying H, Pasca di Magliano M, Crawford HC, Shah YM, Lyssiotis CA. Elife, 2022 Jul 11; 11: DOI:10.7554/eLife.73245
      PMID: 35815941
    • Journal Article
      Hyaluronic acid fuels pancreatic cancer cell growth.
      Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, Zhang L, Pratt MR, Keshari KR, Ying H, Lyssiotis CA. Elife, 2021 Dec 24; 10: DOI:10.7554/eLife.62645
      PMID: 34951587
    • Journal Article
      A guide to interrogating immunometabolism.
      Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. Nat Rev Immunol, 2021 Oct; 21 (10): 637 - 652. DOI:10.1038/s41577-021-00529-8
      PMID: 33859379
    • Journal Article
      Metabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment.
      Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA. Nat Rev Cancer, 2021 Aug; 21 (8): 510 - 525. DOI:10.1038/s41568-021-00375-9
      PMID: 34244683
    Featured News & Stories doctors talking to eachother down a hallway
    Health Lab
    A collaborative approach to pancreatic cancer
    The Rogel and Blondy Center for Pancreatic Cancer is a center of excellence in pancreatic cancer research, combining pioneering research with innovative clinical care and an array of clinical trials. Center co-director Marina Pasca di Magliano explains that the key to a robust research program and responsive care lies in collaboration.
    Department News
    New publication from Rosa Menjivar (Pasca di Magliano lab) in collaboration with Costas Lyssiotis
    "Arginase 1 is a key driver of immune suppression in pancreatic cancer," has been published in eLife.