Ann Arbor
Michigan, 48109-5942 United States
Available to mentor
Prof. Lyssiotis obtained his bachelor’s degree in Chemistry and Biochemistry from the University of Michigan in 2004, his PhD in Chemical Biology from The Scripps Research Institute in 2010, and then completed postdoctoral training in the laboratory of Lewis C. Cantley at Harvard and Cornell. In 2015, Prof. Lyssiotis joined the faculty at the University of Michigan with appointments in the Departments of Physiology and Medicine. His lab studies the biochemical pathways and metabolic requirements that enable tumor survival and growth. This work spans the areas of cancer metabolism, the tumor microenvironment and immunometabolism using and developing protocols in mass spectrometry-based metabolomics. Ultimately, his group aims to transition new information about these processes into targeted therapies for cancer and other diseases. He is the recipient of several junior scholar awards including being named a Lefkofsky Scholar, a Kimmel Scholar, an AACR NextGen young investigator, a Dale F. Frey Breakthrough Scientist, and a V Foundation Fellow.
Lyssiotis Lab
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
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Center MemberRogel Cancer Center
Tumor Metabolism, Cancer Biochemistry, Immunometabolism, Tumor Microenvironment, Pancreatic Cancer, Metabolomics, Immunotherapy, Cancer-Diet Interactions, Diffuse Intrinsic Pontine Glioma (DIPG)
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Nwosu ZC, Ward MH, Sajjakulnukit P, Poudel P, Ragulan C, Kasperek S, Radyk M, Sutton D, Menjivar RE, Andren A, Apiz-Saab JJ, Tolstyka Z, Brown K, Lee H-J, Dzierozynski LN, He X, Ps H, Ugras J, Nyamundanda G, Zhang L, Halbrook CJ, Carpenter ES, Shi J, Shriver LP, Patti GJ, Muir A, Pasca di Magliano M, Sadanandam A, Lyssiotis CA. Nature, 2023 Jun; 618 (7963): 151 - 158.Journal ArticleUridine-derived ribose fuels glucose-restricted pancreatic cancer.
DOI:10.1038/s41586-023-06073-w PMID: 37198494 -
Halbrook CJ, Lyssiotis CA, Pasca di Magliano M, Maitra A. Cell, 2023 Apr 13; 186 (8): 1729 - 1754.Journal ArticlePancreatic cancer: Advances and challenges.
DOI:10.1016/j.cell.2023.02.014 PMID: 37059070 -
Hong HS, Mbah NE, Shan M, Loesel K, Lin L, Sajjakulnukit P, Correa LO, Andren A, Lin J, Hayashi A, Magnuson B, Chen J, Li Z, Xie Y, Zhang L, Goldstein DR, Carty SA, Lei YL, Opipari AW, Argüello RJ, Kryczek I, Kamada N, Zou W, Franchi L, Lyssiotis CA. Sci Immunol, 2022 Nov 25; 7 (77): eabm8182Journal ArticleOXPHOS promotes apoptotic resistance and cellular persistence in TH17 cells in the periphery and tumor microenvironment.
DOI:10.1126/sciimmunol.abm8182 PMID: 36399539 -
Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Nat Cancer, 2022 Nov; 3 (11): 1386 - 1403.Journal ArticleDifferential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.
DOI:10.1038/s43018-022-00463-1 PMID: 36411320 -
Kerk SA, Lin L, Myers AL, Sutton DJ, Andren A, Sajjakulnukit P, Zhang L, Zhang Y, Jiménez JA, Nelson BS, Chen B, Robinson A, Thurston G, Kemp SB, Steele NG, Hoffman MT, Wen H-J, Long D, Ackenhusen SE, Ramos J, Gao X, Nwosu ZC, Galban S, Halbrook CJ, Lombard DB, Piwnica-Worms DR, Ying H, Pasca di Magliano M, Crawford HC, Shah YM, Lyssiotis CA. Elife, 2022 Jul 11; 11:Journal ArticleMetabolic requirement for GOT2 in pancreatic cancer depends on environmental context.
DOI:10.7554/eLife.73245 PMID: 35815941 -
Kim PK, Halbrook CJ, Kerk SA, Radyk M, Wisner S, Kremer DM, Sajjakulnukit P, Andren A, Hou SW, Trivedi A, Thurston G, Anand A, Yan L, Salamanca-Cardona L, Welling SD, Zhang L, Pratt MR, Keshari KR, Ying H, Lyssiotis CA. Elife, 2021 Dec 24; 10:Journal ArticleHyaluronic acid fuels pancreatic cancer cell growth.
DOI:10.7554/eLife.62645 PMID: 34951587 -
Voss K, Hong HS, Bader JE, Sugiura A, Lyssiotis CA, Rathmell JC. Nat Rev Immunol, 2021 Oct; 21 (10): 637 - 652.Journal ArticleA guide to interrogating immunometabolism.
DOI:10.1038/s41577-021-00529-8 PMID: 33859379 -
Kerk SA, Papagiannakopoulos T, Shah YM, Lyssiotis CA. Nat Rev Cancer, 2021 Aug; 21 (8): 510 - 525.Journal ArticleMetabolic networks in mutant KRAS-driven tumours: tissue specificities and the microenvironment.
DOI:10.1038/s41568-021-00375-9 PMID: 34244683
