Richard M Mortensen
Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
[email protected]

Available to mentor
Richard M Mortensen
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
    • About

    We have been investigation the role of obesity, diabetes and metabolite function in cardiovascular disease. Focus has been on the function of PPAR-gamma, mineralocorticoid receptor, inflammation, and the metabolite, itaconate.

    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Metabolism and cardiovascular disease
    Inflammation and Mineralocorticoid Receptor
    PPAR-gamma function

    Recent Publications See All Publications
    • Journal Article
      Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.
      Song J, Zhang Y, Frieler RA, Andren A, Wood S, Tyrrell DJ, Sajjakulnukit P, Deng JC, Lyssiotis CA, Mortensen RM, Salmon M, Goldstein DR. J Clin Invest, 2023 Dec 12; 134 (3): DOI:10.1172/JCI173034
      PMID: 38085578
    • Journal Article
      Itaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation.
      Li Y, Singh S, Breckenridge HA, Cui TX, Vigil TM, Kreger JE, Lei J, Wong HKA, Sajjakulnukit P, Zhou X, Kelley Bentley J, Lyssiotis CA, Mortensen RM, Hershenson MB. Mucosal Immunol, 2024 Aug 13; DOI:10.1016/j.mucimm.2024.08.001
      PMID: 39147278
    • Journal Article
      Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance.
      Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, Yang H, Pitter M, Yu J, Liao P, Zhou J, Vatan L, Grove S, Wei S, Vigil T, Shah YM, Mortensen R, Kryczek I, Garmire L, Sivaccumar JP, Ramesh AK, Zhang N, An Z, Wang S, Zou W. Cancer Cell, 2024 Dec 9; 42 (12): 2032 - 2044.e6. DOI:10.1016/j.ccell.2024.10.010
      PMID: 39515327
    • Journal Article
      Metabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
      Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Sci Transl Med, 2023 Feb 8; 15 (682): eade3782 DOI:10.1126/scitranslmed.ade3782
      PMID: 36753565
    • Journal Article
      Aconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice.
      Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM. Obesity (Silver Spring), 2022 Sep; 30 (9): 1818 - 1830. DOI:10.1002/oby.23509
      PMID: 35927796
    • Proceeding / Abstract / Poster
      Itaconate Is Required for Anti-Inflammation During Rhinovirus Infection
      Li Y, Vigil T, Kuo S, Goldsmith A, Bentley JK, Mortensen R, Hershenson MB. 2022 May; a2601 - a2601. DOI:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2601
    • Journal Article
      NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
      Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T. Circ Res, 2022 Jan 21; 130 (2): 234 - 248. DOI:10.1161/CIRCRESAHA.121.318898
      PMID: 34875852
    • Journal Article
      Aconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice.
      Vigil TM, Frieler RA, Kilpatrick KL, Wang MM, Mortensen RM. Exp Neurol, 2022 Jan; 347: 113902 DOI:10.1016/j.expneurol.2021.113902
      PMID: 34699789