Professor of Molecular and Integrative Physiology
Professor of Internal Medicine
[email protected]
Available to mentor
Richard M Mortensen
Professor
We have been investigation the role of obesity, diabetes and metabolite function in cardiovascular disease. Focus has been on the function of PPAR-gamma, mineralocorticoid receptor, inflammation, and the metabolite, itaconate.
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
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Center MemberCaswell Diabetes Institute
Metabolism and cardiovascular disease
Inflammation and Mineralocorticoid Receptor
PPAR-gamma function
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Song J, Zhang Y, Frieler RA, Andren A, Wood S, Tyrrell DJ, Sajjakulnukit P, Deng JC, Lyssiotis CA, Mortensen RM, Salmon M, Goldstein DR. J Clin Invest, 2023 Dec 12; 134 (3):Journal ArticleItaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.
DOI:10.1172/JCI173034 PMID: 38085578 -
Li Y, Singh S, Breckenridge HA, Cui TX, Vigil TM, Kreger JE, Lei J, Wong HKA, Sajjakulnukit P, Zhou X, Kelley Bentley J, Lyssiotis CA, Mortensen RM, Hershenson MB. Mucosal Immunol, 2024 Aug 13;Journal ArticleItaconate suppresses house dust mite-induced allergic airways disease and Th2 cell differentiation.
DOI:10.1016/j.mucimm.2024.08.001 PMID: 39147278 -
Lin H, Tison K, Du Y, Kirchhoff P, Kim C, Wang W, Yang H, Pitter M, Yu J, Liao P, Zhou J, Vatan L, Grove S, Wei S, Vigil T, Shah YM, Mortensen R, Kryczek I, Garmire L, Sivaccumar JP, Ramesh AK, Zhang N, An Z, Wang S, Zou W. Cancer Cell, 2024 Nov 1;Journal ArticleItaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance.
DOI:10.1016/j.ccell.2024.10.010 PMID: 39515327 -
Lei I, Huang W, Noly PE, Naik S, Ghali M, Liu L, Pagani FD, Abou El Ela A, Pober JS, Pitt B, Platt JL, Cascalho M, Wang Z, Chen YE, Mortensen RM, Tang PC. Sci Transl Med, 2023 Feb 8; 15 (682): eade3782Journal ArticleMetabolic reprogramming by immune-responsive gene 1 up-regulation improves donor heart preservation and function.
DOI:10.1126/scitranslmed.ade3782 PMID: 36753565 -
Frieler RA, Vigil TM, Song J, Leung C, Goldstein DR, Lumeng CN, Mortensen RM. Obesity (Silver Spring), 2022 Sep; 30 (9): 1818 - 1830.Journal ArticleAconitate decarboxylase 1 regulates glucose homeostasis and obesity in mice.
DOI:10.1002/oby.23509 PMID: 35927796 -
Li Y, Vigil T, Kuo S, Goldsmith A, Bentley JK, Mortensen R, Hershenson MB. 2022 May; a2601 - a2601.Proceeding / Abstract / PosterItaconate Is Required for Anti-Inflammation During Rhinovirus Infection
DOI:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a2601 -
Inazumi H, Kuwahara K, Nakagawa Y, Kuwabara Y, Numaga-Tomita T, Kashihara T, Nakada T, Kurebayashi N, Oya M, Nonaka M, Sugihara M, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Motoki H, Yamada M, Morimoto S, Otsu K, Mortensen RM, Nakao K, Kimura T. Circ Res, 2022 Jan 21; 130 (2): 234 - 248.Journal ArticleNRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis.
DOI:10.1161/CIRCRESAHA.121.318898 PMID: 34875852 -
Vigil TM, Frieler RA, Kilpatrick KL, Wang MM, Mortensen RM. Exp Neurol, 2022 Jan; 347: 113902Journal ArticleAconitate decarboxylase 1 suppresses cerebral ischemia-reperfusion injury in mice.
DOI:10.1016/j.expneurol.2021.113902 PMID: 34699789