1241 E. Catherine St., Rm 4909 Buhl Bldg.
Ann Arbor, Michigan 48109-5618
Available to mentor
John V. Moran, Ph.D. is the Gilbert S. Omenn Collegiate Professor of Human Genetics and a Professor of Internal Medicine at the University of Michigan Medical School. He received a B.S. degree in Chemistry from the Rochester Institute of Technology. He conducted graduate studies with Dr. Philip S. Perlman, earning a M.S. degree in Molecular Genetics from The Ohio State University and a Ph.D. degree in Biochemistry from the University of Texas Southwestern Medical School in Dallas. His graduate research focused on elucidating group I and group II intron mobility mechanisms in Saccharomyces cerevisiae mitochondrial DNA. He conducted postdoctoral studies with Dr. Haig H. Kazazian at the Johns Hopkins Medical Institute and the University of Pennsylvania Medical School as a Damon Runyon/Walter Winchell Cancer Research Fund Fellow. His postdoctoral research focused on developing systems to study the mobility of Long Interspersed Element-1 retrotransposons in cultured human cells. Dr. Moran became a faculty member at the University of Michigan Medical School in 1998. He was promoted to Associate Professor in the Departments of Human Genetics (with tenure) and Internal Medicine (without tenure) in 2003, and to Full Professor of Human Genetics (with tenure) and Internal Medicine (without tenure) in September 2008. Dr. Moran is an alumnus of the Howard Hughes Medical Institute, is a Fellow of the American Association for the Advancement of Science, received the 2013 Curt Stern Award from the American Society of Human Genetics, and recently served on the American Society of Human Genetics Board of Directors. Dr. Moran has licensed reagents to Merck Pharmaceutical, was a paid consultant for a company in Europe & Gilead Sciences, and currently serves on the Scientific Advisory Board of Tessera Therapeutics (where he has equity options and is a paid consultant).
Moran Publications Google Scholar Moran ResearchGate Profile Moran MY NCBI Collection Moran 50 Years Since the Discovery of Reverse Transcriptase at CSHL in 2022 youtube
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Damon Runyon Walter/Winchell Cancer Research Fund Postdoctoral FellowThe University of Pennsylvania School of Medicine, Genetics, 1998
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Postdoctoral FellowJohns Hopkins University School of Medicine, Pediatrics, 1994
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Center MemberRogel Cancer Center
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Center MemberCenter for Computational Medicine and Bioinformatics
Since arriving at Michigan, Dr. Moran’s laboratory has been at the forefront of human transposable element research and has made important discoveries about the mechanism of LINE-1 and Short Interspersed Element (SINE) retrotransposition and their impact on the structure and function of the human genome. His laboratory currently uses a battery of multidisciplinary approaches to answer the following questions: (1) What are the molecular mechanisms responsible for LINE-1 and SINE retrotransposition? (2) To what extent do somatic and germline LINE-1 and SINE retrotransposition affect the structure and function of the human genome? and (3) What host factors influence LINE-1 and SINE retrotransposition? Dr. Moran has published approximately 100 articles (the total includes articles, book chapters, perspectives, and a thesis) and developed many of the assays to study LINE-1 biology. The Moran laboratory is always on the lookout for motivated students and postdoctoral fellows. If you are interested in one of these positions, please contact Dr. Moran by email at: [email protected]
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Sun C, Kathuria K, Emery SB, Kim B, Burbulis IE, Shin JH, Brain Somatic Mosaicism Network , Weinberger DR, Moran JV, Kidd JM, Mills RE, McConnell MJ. Nat Commun, 2024 May 17; 15 (1): 4220Journal ArticleMapping recurrent mosaic copy number variation in human neurons.
DOI:10.1038/s41467-024-48392-0 PMID: 38760338 -
Moldovan JB, Kopera HC, Liu Y, Garcia-Canadas M, Catalina P, Leone PE, Sanchez L, Kitzman JO, Kidd JM, Garcia-Perez JL, Moran JV. Nucleic Acids Res, 2024 Jul 22; 52 (13): 7761 - 7779.Journal ArticleVariable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processes.
DOI:10.1093/nar/gkae448 PMID: 38850156 -
Luqman-Fatah A, Watanabe Y, Uno K, Ishikawa F, Moran JV, Miyoshi T. Nat Commun, 2023 Jan 13; 14 (1): 203Journal ArticleThe interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction.
DOI:10.1038/s41467-022-35757-6 PMID: 36639706 -
Ward JR, Khan A, Torres S, Crawford B, Nock S, Frisbie T, Moran JV, Longworth MS. Nucleic Acids Res, 2022 Oct 14; 50 (18): 10680 - 10694.Journal ArticleCondensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1.
DOI:10.1093/nar/gkac802 PMID: 36169232 -
Moran JV, Wilson TE. Cell, 2022 Sep 29; 185 (20): 3643 - 3645.Journal ArticleReverse transcriptase meets DNA, again: Possible roles for transposable elements in host DNA repair.
DOI:10.1016/j.cell.2022.09.012 PMID: 36179663 -
Moran JV, Gilbert N. 2022 Jun 1; Mobile DNA II, 836 - 869.ChapterMammalian line-1 retrotransposons and related elements
DOI:10.1128/9781555817954.ch35 -
Mortimer SM, Frisbie TJ, Moldovan JB, Nakamura M, Sandwith SN, Yin J, Moran JV. 2022 Encyclopedia of Life Sciences,ChapterChromosomes: Noncoding DNA (including Satellite DNA)
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Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Brain Somatic Mosaicism Network , Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A. Genome Biol, 2021 Mar 29; 22 (1): 92Journal ArticleComprehensive identification of somatic nucleotide variants in human brain tissue.
DOI:10.1186/s13059-021-02285-3 PMID: 33781308