John V Moran
Gilbert S Omenn Collegiate Professor of Human Genetics
Professor of Human Genetics
Professor of Internal Medicine and Program Associate
PhD Graduate Program in Genetics and Genomics
Department of Human Genetics
1241 E. Catherine St., Rm 4909 Buhl Bldg.
Ann Arbor, Michigan 48109-5618
[email protected]

Available to mentor

John V Moran
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    John V. Moran, Ph.D. is the Gilbert S. Omenn Collegiate Professor of Human Genetics and a Professor of Internal Medicine at the University of Michigan Medical School. He received a B.S. degree in Chemistry from the Rochester Institute of Technology. He conducted graduate studies with Dr. Philip S. Perlman, earning a M.S. degree in Molecular Genetics from The Ohio State University and a Ph.D. degree in Biochemistry from the University of Texas Southwestern Medical School in Dallas. His graduate research focused on elucidating group I and group II intron mobility mechanisms in Saccharomyces cerevisiae mitochondrial DNA. He conducted postdoctoral studies with Dr. Haig H. Kazazian at the Johns Hopkins Medical Institute and the University of Pennsylvania Medical School as a Damon Runyon/Walter Winchell Cancer Research Fund Fellow. His postdoctoral research focused on developing systems to study the mobility of Long Interspersed Element-1 retrotransposons in cultured human cells. Dr. Moran became a faculty member at the University of Michigan Medical School in 1998. He was promoted to Associate Professor in the Departments of Human Genetics (with tenure) and Internal Medicine (without tenure) in 2003, and to Full Professor of Human Genetics (with tenure) and Internal Medicine (without tenure) in September 2008. Dr. Moran is an alumnus of the Howard Hughes Medical Institute, is a Fellow of the American Association for the Advancement of Science, received the 2013 Curt Stern Award from the American Society of Human Genetics, and recently served on the American Society of Human Genetics Board of Directors. Dr. Moran has licensed reagents to Merck Pharmaceutical, was a paid consultant for a company in Europe & Gilead Sciences, and currently serves on the Scientific Advisory Board of Tessera Therapeutics (where he has equity options and is a paid consultant).

    Links
    • Moran Publications Google Scholar
    • Moran ResearchGate Profile
    • Moran MY NCBI Collection
    • Moran 50 Years Since the Discovery of Reverse Transcriptase at CSHL in 2022
    • youtube
    Qualifications
    • Damon Runyon Walter/Winchell Cancer Research Fund Postdoctoral Fellow
      The University of Pennsylvania School of Medicine, Genetics, 1998
    • Postdoctoral Fellow
      Johns Hopkins University School of Medicine, Pediatrics, 1994
    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    Research Overview

    Since arriving at Michigan, Dr. Moran’s laboratory has been at the forefront of human transposable element research and has made important discoveries about the mechanism of LINE-1 and Short Interspersed Element (SINE) retrotransposition and their impact on the structure and function of the human genome. His laboratory currently uses a battery of multidisciplinary approaches to answer the following questions: (1) What are the molecular mechanisms responsible for LINE-1 and SINE retrotransposition? (2) To what extent do somatic and germline LINE-1 and SINE retrotransposition affect the structure and function of the human genome? and (3) What host factors influence LINE-1 and SINE retrotransposition? Dr. Moran has published approximately 100 articles (the total includes articles, book chapters, perspectives, and a thesis) and developed many of the assays to study LINE-1 biology. The Moran laboratory is always on the lookout for motivated students and postdoctoral fellows. If you are interested in one of these positions, please contact Dr. Moran by email at: [email protected]

    Recent Publications See All Publications
    • Journal Article
      Mapping recurrent mosaic copy number variation in human neurons.
      Sun C, Kathuria K, Emery SB, Kim B, Burbulis IE, Shin JH, Brain Somatic Mosaicism Network , Weinberger DR, Moran JV, Kidd JM, Mills RE, McConnell MJ. Nat Commun, 2024 May 17; 15 (1): 4220 DOI:10.1038/s41467-024-48392-0
      PMID: 38760338
    • Journal Article
      Variable patterns of retrotransposition in different HeLa strains provide mechanistic insights into SINE RNA mobilization processes.
      Moldovan JB, Kopera HC, Liu Y, Garcia-Canadas M, Catalina P, Leone PE, Sanchez L, Kitzman JO, Kidd JM, Garcia-Perez JL, Moran JV. Nucleic Acids Res, 2024 Jul 22; 52 (13): 7761 - 7779. DOI:10.1093/nar/gkae448
      PMID: 38850156
    • Journal Article
      The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction.
      Luqman-Fatah A, Watanabe Y, Uno K, Ishikawa F, Moran JV, Miyoshi T. Nat Commun, 2023 Jan 13; 14 (1): 203 DOI:10.1038/s41467-022-35757-6
      PMID: 36639706
    • Journal Article
      Condensin I and condensin II proteins form a LINE-1 dependent super condensin complex and cooperate to repress LINE-1.
      Ward JR, Khan A, Torres S, Crawford B, Nock S, Frisbie T, Moran JV, Longworth MS. Nucleic Acids Res, 2022 Oct 14; 50 (18): 10680 - 10694. DOI:10.1093/nar/gkac802
      PMID: 36169232
    • Journal Article
      Reverse transcriptase meets DNA, again: Possible roles for transposable elements in host DNA repair.
      Moran JV, Wilson TE. Cell, 2022 Sep 29; 185 (20): 3643 - 3645. DOI:10.1016/j.cell.2022.09.012
      PMID: 36179663
    • Chapter
      Mammalian line-1 retrotransposons and related elements
      Moran JV, Gilbert N. 2022 Jun 1; Mobile DNA II, 836 - 869. DOI:10.1128/9781555817954.ch35
    • Chapter
      Chromosomes: Noncoding DNA (including Satellite DNA)
      Mortimer SM, Frisbie TJ, Moldovan JB, Nakamura M, Sandwith SN, Yin J, Moran JV. 2022 Encyclopedia of Life Sciences,
    • Journal Article
      Comprehensive identification of somatic nucleotide variants in human brain tissue.
      Wang Y, Bae T, Thorpe J, Sherman MA, Jones AG, Cho S, Daily K, Dou Y, Ganz J, Galor A, Lobon I, Pattni R, Rosenbluh C, Tomasi S, Tomasini L, Yang X, Zhou B, Akbarian S, Ball LL, Bizzotto S, Emery SB, Doan R, Fasching L, Jang Y, Juan D, Lizano E, Luquette LJ, Moldovan JB, Narurkar R, Oetjens MT, Rodin RE, Sekar S, Shin JH, Soriano E, Straub RE, Zhou W, Chess A, Gleeson JG, Marquès-Bonet T, Park PJ, Peters MA, Pevsner J, Walsh CA, Weinberger DR, Brain Somatic Mosaicism Network , Vaccarino FM, Moran JV, Urban AE, Kidd JM, Mills RE, Abyzov A. Genome Biol, 2021 Mar 29; 22 (1): 92 DOI:10.1186/s13059-021-02285-3
      PMID: 33781308
    Featured News & Stories
    Department News
    Highlighted Publications - July 2024
    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News
    Highlighted Publications - June 2024
    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.
    Department News
    Highlighted Publications - May 2024
    Department of Human Genetics faculty are involved in widely diverse areas of research, from Genome Structure and Function research to Evolutionary and Population Genetics.