Giancarlo Vanini, MD
Associate Professor of Anesthesiology
Medical School
Anesthesiology
7433 Medical Science Building I, 1150 West Medical Center Drive
Ann Arbor, Michigan 48109-0615
[email protected]

Available to mentor
Giancarlo Vanini, MD
Associate Professor
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
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    Qualifications
    • Postdoctoral Fellow
      University of Michigan Medical School, Anesthesiology, 2009
    • Residency in Critical Care Medicine
      School of Medicine, Universidad de la República, Montevideo, 2005
    • MD
      School of Medicine, Universidad de la República, 2000
    Research Overview

    - Regulation of Arousal States and Neural Correlates of Consciousness.- Research in my laboratory focuses on the neural mechanisms underlying the generation of arousal states of sleep and wakefulness (circuit level), as well as the neural regulation of the loss and resumption of consciousness concerning general anesthesia.

    - Sleep and Pain Interactions.- Ongoing studies in my lab aim to understand the brain circuitry by which sleep disruption increases pain and paves the way for chronic pain. Current research also focuses on the efficacy of psychedelic therapy and its mechanistic underpinnings in rodent models of chronic pain.

    Links
    • https://vanini.med.umich.edu/
    • twitter
    • linkedin
    • https://scholar.google.com/citations?user=xPlu5hkAAAAJ&hl=en
    Recent Publications See All Publications
    • Journal Article
      Intravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex
      Silverstein BH, Kolbman N, Nelson A, Liu T, Guzzo P, Gilligan J, Lee UC, Mashour GA, Vanini G, Pal D. Translational Psychiatry, 2025 Dec 1; 15 (1): DOI:10.1038/s41398-025-03308-4
      PMID: 40128190
    • Journal Article
      Corrigendum to “Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats” [Br J Anaesth 132 (2024) 1248–1259, (S0007091223006396), (10.1016/j.bja.2023.11.014)]
      Silverstein BH, Parkar A, Groenhout T, Fracz Z, Fryzel AM, Fields CW, Nelson A, Liu T, Vanini G, Mashour GA, Pal D. British Journal of Anaesthesia, 2025 Jan 1; 134 (1): 257 DOI:10.1016/j.bja.2024.10.004
      PMID: 39482149
    • Presentation
      Presentation: Preoptic-PAG Pathway Linking Sleep Loss and Pain
      Vanini G. 2025 Feb 19;
    • Journal Article
      Tetrodotoxin-mediated Inactivation of Medial Prefrontal Cortex Decreases Wakefulness and Rapid Eye Movement Sleep, and Increases Slow-Wave Sleep in Rat.
      Groenhout T, Ponnaluri S, Sharba L, Liu T, Nelson A, Hambrecht-Wiedbusch VS, Vanini G, Pal D. Sleep, 2025 Mar 5; DOI:10.1093/sleep/zsae260
    • Journal Article
      Are orexins–hypocretins the culprit for rapid eye movement sleep behavior disorder in narcolepsy?
      Vanini G. Sleep, 2024 Nov 1; 47 (11): DOI:10.1093/sleep/zsae208
      PMID: 39238164
    • Journal Article
      Regulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons
      Mondino A, Jadidian A, Toth B, Hambrecht-Wiedbusch VS, Floran-Garduno L, Li D, York AK, Torterolo P, Burgess C, Mashour GA, Vanini G. bioRxiv, 2025 Feb 25;
    • Proceeding / Abstract / Poster
      Sleep Disruption in a Mouse Model of Surgery Differs as a Function of Sex and Genotype
      Jadidian A, Hambrecht-Wiedbusch V, Floran-Garduno L, Fayad H, Mashour G, Vanini G. 2024 Oct 5;
    • Presentation
      Dissecting preoptic circuitry controlling arousal states, affect and pain
      Vanini G. 2024 Jul 8;
    Featured News & Stories
    Department News
    Fourteen faculty promotions announced
    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.