Giancarlo Vanini, MD
Associate Professor of Anesthesiology
Medical School
University of Michigan
Anesthesiology
7433 Medical Science Building I, 1150 West Medical Center Drive
Ann Arbor, Michigan 48109-0615
[email protected]
Anesthesiology
7433 Medical Science Building I, 1150 West Medical Center Drive
Ann Arbor, Michigan 48109-0615
Available to mentor
Giancarlo Vanini, MD
Associate Professor
Manage Your Profile
Qualifications
-
Postdoctoral FellowUniversity of Michigan Medical School, Anesthesiology, Ann Arbor, United States
2005 - 2009
Postdoctoral Fellowship
-
Residency in Critical Care MedicineSchool of Medicine, Universidad de la República, Montevideo, Uruguay
2001 - 2005
Residency
-
MDSchool of Medicine, Universidad de la República, Montevideo, Uruguay
1992 - 2000
Research Overview
- Regulation of Arousal States and Neural Correlates of Consciousness.- Research in my laboratory focuses on the neural mechanisms underlying the generation of arousal states of sleep and wakefulness (circuit level), as well as the neural regulation of the loss and resumption of consciousness concerning general anesthesia.
- Sleep and Pain Interactions.- Ongoing studies in my lab aim to understand the brain circuitry by which sleep disruption increases pain and paves the way for chronic pain. Current research also focuses on the efficacy of psychedelic therapy and its mechanistic underpinnings in rodent models of chronic pain.
Links
Recent Publications
-
Silverstein BH, Kolbman N, Nelson A, Liu T, Guzzo P, Gilligan J, Lee UC, Mashour GA, Vanini G, Pal D. Translational Psychiatry, 2025 Dec 1; 15 (1):Journal ArticleIntravenous psilocybin induces dose-dependent changes in functional network organization in rat cortex
DOI:10.1038/s41398-025-03308-4 PMID: 40128190 -
Kolbman N, Huels ER, Nelson A, Summerfield R, Byraju K, Groenhout T, Liu T, Hudetz AG, Vanini G, Pal D. 2025 Oct 17; bioRxiv,PreprintIntravenous Administration of Serotonergic Psychedelics Produce Short-lasting Changes in Sleep-Wake Behavior and High Gamma Functional Connectivity in Rats
DOI:10.1101/2025.10.12.681880 -
Silverstein BH, Parkar A, Groenhout T, Fracz Z, Fryzel AM, Fields CW, Nelson A, Liu T, Vanini G, Mashour GA, Pal D. British Journal of Anaesthesia, 2025 Jan 1; 134 (1): 257Journal ArticleCorrigendum to “Effect of prolonged sedation with dexmedetomidine, midazolam, propofol, and sevoflurane on sleep homeostasis in rats” [Br J Anaesth 132 (2024) 1248–1259, (S0007091223006396), (10.1016/j.bja.2023.11.014)]
DOI:10.1016/j.bja.2024.10.004 PMID: 39482149 -
Vanini G. 2025 Feb 19;PresentationPresentation: Preoptic-PAG Pathway Linking Sleep Loss and Pain
-
Groenhout T, Ponnaluri S, Sharba L, Liu T, Nelson A, Hambrecht-Wiedbusch VS, Vanini G, Pal D. Sleep, 2025 Mar 5;Journal ArticleTetrodotoxin-mediated Inactivation of Medial Prefrontal Cortex Decreases Wakefulness and Rapid Eye Movement Sleep, and Increases Slow-Wave Sleep in Rat.
DOI:10.1093/sleep/zsae260 -
Vanini G. Sleep, 2024 Nov 1; 47 (11):Journal ArticleAre orexins–hypocretins the culprit for rapid eye movement sleep behavior disorder in narcolepsy?
DOI:10.1093/sleep/zsae208 PMID: 39238164 -
Mondino A, Jadidian A, Toth B, Hambrecht-Wiedbusch VS, Floran-Garduno L, Li D, York AK, Torterolo P, Burgess C, Mashour GA, Vanini G. bioRxiv, 2025 Feb 25;Journal ArticleRegulation of REM Sleep Onset and Homeostasis by Preoptic Glutamatergic Neurons
-
Jadidian A, Hambrecht-Wiedbusch V, Floran-Garduno L, Fayad H, Mashour G, Vanini G. 2024 Oct 5;Proceeding / Abstract / PosterSleep Disruption in a Mouse Model of Surgery Differs as a Function of Sex and Genotype
Featured News & Stories
Department News
Fourteen faculty promotions announced
The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.
