Giancarlo Vanini
Associate Professor of Anesthesiology
7433 Medical Science Building I, 1150 West Medical Center Drive
Ann Arbor, Michigan 48109-0615
[email protected]

Available to mentor

Giancarlo Vanini
Associate Professor
  • Qualifications
  • Research Overview
  • Links
  • Recent Publications
  • Qualifications
    • Postdoctoral Fellow
      University of Michigan Medical School, Anesthesiology, 2009
    • Residency in Critical Care Medicine
      School of Medicine, Universidad de la República, Montevideo, 2005
    • MD
      School of Medicine, Universidad de la República, Montevideo, 2000
    Research Overview

    - Regulation of Arousal States and Neural Correlates of Consciousness.- Research in my laboratory focuses on the neural mechanisms underlying the generation of arousal states of sleep and wakefulness, as well as the neural regulation of the loss and resumption of consciousness with respect to general anesthesia.

    - Sleep and Pain Interactions.- Ongoing studies in my lab aim to understand the brain circuitry by which sleep disruption increases pain and paves the way for chronic pain.

    - Mechanisms of Hypothermia.- We study the neural underpinnings of hypothermia during sleep and hypometabolic states (torpor), and their potential implications in neuroprotection.

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    Recent Publications See All Publications
    • Journal Article
      Hormonal basis of sex differences in anesthetic sensitivity.
      Wasilczuk AZ, Rinehart C, Aggarwal A, Stone ME, Mashour GA, Avidan MS, Kelz MB, Proekt A, ReCCognition Study Group . Proc Natl Acad Sci U S A, 2024 Jan 16; 121 (3): e2312913120 DOI:10.1073/pnas.2312913120
      PMID: 38190526
    • Journal Article
      Intravenous psilocybin attenuates mechanical hypersensitivity in a rat model of chronic pain.
      Kolbman N, Liu T, Guzzo P, Gilligan J, Mashour GA, Vanini G, Pal D. Curr Biol, 2023 Dec 18; 33 (24): R1282 - R1283. DOI:10.1016/j.cub.2023.10.016
      PMID: 38113836
    • Journal Article
      Narcolepsy: Mending a broken neural circuit that controls arousal.
      Vanini G. Curr Biol, 2023 Apr 24; 33 (8): R316 - R318. DOI:10.1016/j.cub.2023.02.053
      PMID: 37098337
    • Journal Article
      The posterior dominant rhythm: an electroencephalographic biomarker for cognitive recovery after general anaesthesia.
      Labonte AK, Kafashan M, Huels ER, Blain-Moraes S, Basner M, Kelz MB, Mashour GA, Avidan MS, Palanca BJA, ReCCognition Study Group . Br J Anaesth, 2023 Feb; 130 (2): e233 - e242. DOI:10.1016/j.bja.2022.01.019
      PMID: 35183346
    • Presentation
      Zooming into preoptic glutamatergic mechanisms controlling arousal, anesthesia and cortical dynamics
      2022 Dec 1;
    • Presentation
      Panel Presentation: Snap-Talk in the Fundamentals of Anesthesiology Track
      2022 Oct 1;
    • Presentation
      Panel Presentation: Preoptic Glutamatergic Neurons Promote Wakefulness, Suppress REM Sleep, and Reduce Body Temperature - The Preoptic Area in Sleep and Arousal
      2022 Jun 1;
    • Presentation
      Plenary Presentaion: Preoptic Hypothalamic Mechanisms Controlling Sleep-Wake States Do Not Influence the Loss and Recovery of Consciousness Associated with Isoflurane Anesthesia
      2022 Apr 1;
    Featured News & Stories
    Department News
    Fourteen faculty promotions announced
    The University of Michigan Regents approved 14 Department of Anesthesiology faculty promotions during their May 2023 meeting. Promotions will go into effect September 1.