Available to mentor
Thomas Hudson Sanderson, PhD is an Associate Professor in the Departments of Emergency Medicine and Molecular and Integrative Physiology at the University of Michigan Medical School. Dr. Sanderson serves as a reviewer for multiple granting agencies, including the American Heart Association as Chair of the Collaborative Science Award Committee, the Department of Defense, and recently completed a 6-year term as standing member of the Neural Oxidative Metabolism, Mitochondria and Cell Death Study Section for the National Institutes of Health. Dr. Sanderson currently serves as an associate editor for the FASEB Journal. Research in the Sanderson lab is focused on understanding brain damage caused by acute ischemic or traumatic insults to the brain suffered during cardiac arrest, ischemic stroke, neonatal hypoxia/ischemia, and trauma. Ongoing mechanistic studies are focused on uncovering novel pathologic mechanisms of inner mitochondrial membrane proteins involved in mitochondrial dynamics, quality control, cristae maintenance, and cell death execution. A second area of focus is the development and clinical translation of neuroprotective therapies that modulate the activity of mitochondria to reduce brain injury. Pre-clinical large animal studies are ongoing to evaluate a novel therapeutic strategy that limits mitochondrial hyperactivity and reduces brain injury following ischemia or trauma. This research has resulted in multiple awarded US patents, which formed the foundation of a startup company focused on bringing novel therapies to clinical implementation for ischemic brain injury. Ongoing studies supported by the NIH and DoD are focused on investigating the mechanisms of this therapy through continued testing in translational models of disease, along with regulatory testing of human therapy devices that can bring this treatment to the clinic.
Sanderson Lab Mitovation, Inc.
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Postdoctoral FellowshipWayne State University, Detroit, 2008
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PhDWayne State University School of Medicine, Physiology, 2006
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BSWestern Michigan University, Kalamazoo, 2001
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Center MemberCenter for Integrative Research in Critical Care
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Correa-Medero LO, Jankowski SE, Hong HS, Armas ND, Vijendra AI, Reynolds MB, Fogo GM, Awad D, Dils AT, Inoki KA, Williams RG, Ye AM, Svezhova N, Gomez-Rivera F, Collins KL, O'Riordan MX, Sanderson TH, Lyssiotis CA, Carty SA. Cell Rep, 2024 Apr 29; 43 (5): 114156Journal ArticleER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection.
DOI:10.1016/j.celrep.2024.114156 PMID: 38687642 -
Kumar A, Ye C, Nkansah A, Decoville T, Fogo GM, Sajjakulnukit P, Reynolds MB, Zhang L, Quaye O, Seo Y-A, Sanderson TH, Lyssiotis CA, Chang C-H. Proc Natl Acad Sci U S A, 2024 Apr 23; 121 (17): e2318420121Journal ArticleIron regulates the quiescence of naive CD4 T cells by controlling mitochondria and cellular metabolism.
DOI:10.1073/pnas.2318420121 PMID: 38621136 -
Morse PT, Arroum T, Wan J, Pham L, Vaishnav A, Bell J, Pavelich L, Malek MH, Sanderson TH, Edwards BFP, Hüttemann M. Cells, 2024 Mar 12; 13 (6):Journal ArticlePhosphorylations and Acetylations of Cytochrome c Control Mitochondrial Respiration, Mitochondrial Membrane Potential, Energy, ROS, and Apoptosis.
DOI:10.3390/cells13060493 PMID: 38534337 -
Chandran S, Sanderson TH. Stroke, 2024 Feb; 55 (Suppl_1):Proceeding / Abstract / PosterAbstract TP32: Sirtuin 3 Regulation of Mitochondrial Dynamics and Neuronal Apoptosis During Ischemia/Reperfusion
DOI:10.1161/str.55.suppl_1.tp32 -
Morse PT, Pérez-Mejías G, Wan J, Turner AA, Márquez I, Kalpage HA, Vaishnav A, Zurek MP, Huettemann PP, Kim K, Arroum T, De la Rosa MA, Chowdhury DD, Lee I, Brunzelle JS, Sanderson TH, Malek MH, Meierhofer D, Edwards BFP, Díaz-Moreno I, Hüttemann M. Nat Commun, 2023 Jul 13; 14 (1): 4166Journal ArticleCytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle.
DOI:10.1038/s41467-023-39820-8 PMID: 37443314 -
Wider JM, Gruley E, Morse PT, Wan J, Lee I, Anzell AR, Fogo GM, Mathieu J, Hish G, O'Neil B, Neumar RW, Przyklenk K, Hüttemann M, Sanderson TH. Crit Care, 2023 Dec 14; 27 (1): 491Journal ArticleModulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest.
DOI:10.1186/s13054-023-04745-7 PMID: 38098060 -
Morse PT, Tuck S, Kerns M, Goebel DJ, Wan J, Waddell T, Wider JM, Hüttemann CL, Malek MH, Lee I, Sanderson TH, Hüttemann M. Bioeng Transl Med, 2023 May; 8 (3): e10496Journal ArticleNon-invasive treatment of ischemia/reperfusion injury: Effective transmission of therapeutic near-infrared light into the human brain through soft skin-conforming silicone waveguides.
DOI:10.1002/btm2.10496 PMID: 37206207 -
2022 Nov 8;PresentationTranslation of Mitochondrial Modulation Therapy to Treat Acute Brain Injury