Carole Parent
Raymond W Ruddon Collegiate Professor of Cancer Biology and Pharmacology
Professor of Pharmacology
Professor of Cell and Developmental Biology
Research Professor, Life Sciences Institute
Life Sciences Institute
210 Washtenaw Ave, Office 4437
Ann Arbor, MI 48109-2216
[email protected]

Available to mentor

Carole Parent
Research Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Carole A. Parent obtained B.Pharm. and M.Sc. degrees from the Université of Montréal and a Ph.D. degree from the University of Illinois at Chicago. After completing a postdoctoral fellowship in the laboratory of Dr. Peter N. Devreotes in the Department of Biological Chemistry of the Johns Hopkins University School of Medicine Dr. Parent joined the Laboratory of Cellular and Molecular Biology at the NCI in 2000, received tenure in 2006, was appointed Deputy Chief in 2010, and Deputy Director of the Center for Cancer Research at the NCI in 2016. After 17 years at the NCI, Dr. Parent moved to the University of Michigan in 2017 as the inaugural Raymond and Lynne Ruddon Collegiate Professor in Cancer Biology and Pharmacology. She is jointly appointed in the Department of Cell & Developmental Biology. Her laboratory is housed in the Life Sciences Institute of the University of Michigan, where she is a Research Professor. Dr. Parent is a Fellow of the American Society for Cell Biology and of the American Association for the Advancement of Science.

    Links
    • Parent Lab
    Qualifications
    • Instructor
      Johns Hopkins University School of Medicine, Baltimore, 2000
    • Postdoctoral Fellow
      Johns Hopkins University School of Medicine, Biological Chemistry, 1996
    • PhD
      Department of Pharmacodynamics, College of Pharmacy University of Illinois at Chicago, Chicago, 1992
    • MS
      Department of Pharmacology, Faculty of Medicine Université de Montréal, Montréal, 1987
    • BS
      Faculty of Pharmacy Université de Montréal, Montréal, 1985
    Center Memberships
    • Center Member
      Rogel Cancer Center
    Research Overview

    Dr. Parent's research program focuses on identifying the mechanisms that mediate how neutrophils reach infection and injury as well as tumor sites. To do so, her group exploits complementary ex vivo and in vivo model systems, cutting-edge live imaging, and a transdisciplinary approach.

    Recent Publications See All Publications
    • Preprint
      TGFβ1-TNFα regulated secretion of neutrophil chemokines is independent of epithelial-mesenchymal transitions in breast tumor cells.
      SenGupta S, Cohen E, Serrenho J, Ott K, Coulombe PA, Parent CA. 2024 Oct 12; DOI:10.1101/2024.10.11.617845
      PMID: 39416223
    • Journal Article
      496 The stress-induced K16 and K17 differentially regulate innate immune responses in skin
      Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s86 DOI:10.1016/j.jid.2024.06.512
    • Journal Article
      Repeated stress to the skin amplifies neutrophil infiltration in a keratin 17- and PKCα-dependent manner.
      Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. PLoS Biol, 2024 Aug; 22 (8): e3002779 DOI:10.1371/journal.pbio.3002779
      PMID: 39159283
    • Preprint
      Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation.
      Arya SB, Collie SP, Xu Y, Fernandez M, Sexton JZ, Mosalaganti S, Coulombe PA, Parent CA. 2024 Apr 26; DOI:10.1101/2024.04.21.590456
      PMID: 38712240
    • Journal Article
      The ins-and-outs of exosome biogenesis, secretion, and internalization.
      Arya SB, Collie SP, Parent CA. Trends Cell Biol, 2024 Feb; 34 (2): 90 - 108. DOI:10.1016/j.tcb.2023.06.006
      PMID: 37507251
    • Preprint
      Keratin 17- and PKCα-dependent transient amplification of neutrophil influx after repeated stress to the skin.
      Xu Y, Cohen E, Johnson CN, Parent CA, Coulombe PA. 2023 Oct 14; DOI:10.1101/2023.10.11.561954
      PMID: 37873256
    • Journal Article
      TGF-β1 activates neutrophil signaling and gene expression but not migration.
      Hein LE, SenGupta S, Gunasekaran G, Johnson CN, Parent CA. PLoS One, 2023 18 (9): e0290886 DOI:10.1371/journal.pone.0290886
      PMID: 37682817
    • Preprint
      TGF-β1 activates neutrophil signaling and gene expression but not migration.
      Hein LE, SenGupta S, Gunasekaran G, Johnson C, Parent CA. 2023 May 27; DOI:10.1101/2023.05.26.542468
      PMID: 37292899
    Featured News & Stories
    Department News
    New Publication from the Parent Lab
    "The ins-and-outs of exosome biogenesis, secretion, and internalization," has been published in Tends in Cell Biology.
    Department News
    New Publication from the Parent Lab
    "An adaptive and versatile method to quantitate and characterize collective cell migration behaviors on complex surfaces," has been published in Frontiers in Cell and Developmental Biology.