Gilbert S Omenn, MD, PhD
Harold T Shapiro Distinguished University Professor of Medicine
Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
Professor of Human Genetics
Professor of Environmental Health Sciences
[email protected]

Available to mentor

Gilbert S Omenn, MD, PhD
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Gil Omenn is Harold T. Shapiro Distinguished University Professor of Computational Medicine & Bioinformatics, Internal Medicine, Human Genetics, and Public Health at the University of Michigan, Ann Arbor, USA. He served as Executive Vice President for Medical Affairs and as Chief Executive Officer of the University of Michigan Health System from 1997 to 2002. He was Dean of the School of Public Health, and Professor of Medicine and Environmental Health, University of Washington, Seattle, 1982-1997. He is the leader of the global Human Proteome Project (HPP) of the Human Proteome Organization (HUPO). His current research is focused on proteogenomics of alternative splicing in cancers. Splice variants are a major source of protein diversity in multi-cellular organisms with multi-exonic genes. Splice isoforms are good candidates for more specific biomarkers and therapeutic targets. He is author of 548 publications. Omenn has visited China 12 times since 1976. He is an honorary faculty of Peking Union Medical College, affiliate faculty of the Institute for Systems Biology in Seattle, member of the U.S. National Academy of Medicine, past president of the American Association for the Advancement of Science, board member of the Weizmann Institute of Science in Israel, and a director of several biotech companies. He served as a White House Fellow at the U.S. Atomic Energy Commission and as associate director of the White House Office of Science & Technology Policy and Office of Management & Budget. He earned the B.A. from Princeton University, M.D. from Harvard Medical School, and PhD in genetics from University of Washington. He is a musician and tennis player.

    Center Memberships
    • Center Member
      Rogel Cancer Center
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Institute for Healthcare Policy and Innovation
    Research Overview

    Dr. Omenn's research focuses on proteo-genomics of cancers and proteomics informatics. He long chaired and remains active in the Human Proteome Organization (HUPO) global Human Proteome Project (www.thehpp.org). There are datasets for application of analytical tools, and there are research teams eager to engage in collaborative studies in the Chromosome-centric HPP and Biology and Disease-driven HPP initiatives. He is a co-founder of the Consortium for Clinical Characterization of Covid-19 using Electronic Health Records (4CE) organized by the i2b2tranSMART Foundation and Harvard colleagues. He has long-standing interests in mechanisms of genetic predispositions to risks from environmental and occupational exposures (eco-genetics) and science-based risk analyses.

    Recent Publications See All Publications
    • Journal Article
      Frozen tissue coring and layered histological analysis improves cell type-specific proteogenomic characterization of pancreatic adenocarcinoma.
      Savage SR, Wang Y, Chen L, Jewell S, Newton C, Dou Y, Li QK, Bathe OF, Robles AI, Omenn GS, Thiagarajan M, Zhang H, Hostetter G, Zhang B. Clin Proteomics, 2024 Jan 30; 21 (1): 7 DOI:10.1186/s12014-024-09450-3
      PMID: 38291365
    • Journal Article
      Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?
      Sun D, Macedonia C, Chen Z, Chandrasekaran S, Najarian K, Zhou S, Cernak T, Ellingrod VL, Jagadish HV, Marini B, Pai M, Violi A, Rech JC, Wang S, Li Y, Athey B, Omenn GS. J Med Chem, 2024 Sep 26; 67 (18): 16035 - 16055. DOI:10.1021/acs.jmedchem.4c01684
      PMID: 39253942
    • Journal Article
      Comprehensive proteogenomic characterization of rare kidney tumors.
      Li GX, Chen L, Hsiao Y, Mannan R, Zhang Y, Luo J, Petralia F, Cho H, Hosseini N, Leprevost FDV, Calinawan A, Li Y, Anand S, Dagar A, Geffen Y, Kumar-Sinha C, Chugh S, Le A, Ponce S, Guo S, Zhang C, Schnaubelt M, Al Deen NN, Chen F, Caravan W, Houston A, Hopkins A, Newton CJ, Wang X, Polasky DA, Haynes S, Yu F, Jing X, Chen S, Robles AI, Mesri M, Thiagarajan M, An E, Getz GA, Linehan WM, Hostetter G, Jewell SD, Chan DW, Wang P, Omenn GS, Mehra R, Ricketts CJ, Ding L, Chinnaiyan AM, Cieslik MP, Dhanasekaran SM, Zhang H, Nesvizhskii AI, Clinical Proteomic Tumor Analysis Consortium . Cell Rep Med, 2024 May 21; 5 (5): 101547 DOI:10.1016/j.xcrm.2024.101547
      PMID: 38703764
    • Journal Article
      Neurological diagnoses in hospitalized COVID-19 patients associated with adverse outcomes: A multinational cohort study.
      Hutch MR, Son J, Le TT, Hong C, Wang X, Shakeri Hossein Abad Z, Morris M, Gutiérrez-Sacristán A, Klann JG, Spiridou A, Batugo A, Bellazzi R, Benoit V, Bonzel C-L, Bryant WA, Chiudinelli L, Cho K, Das P, González González T, Hanauer DA, Henderson DW, Ho Y-L, Loh NHW, Makoudjou A, Makwana S, Malovini A, Moal B, Mowery DL, Neuraz A, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Talbert J, Tan ALM, Tan BWL, Tan BWQ, Tibollo V, Tippman P, Verdy G, Yuan W, Avillach P, Gehlenborg N, Omenn GS, Consortium for Clinical Characterization of COVID-19 by EHR (4CE) , Visweswaran S, Cai T, Luo Y, Xia Z. PLOS Digit Health, 2024 Apr; 3 (4): e0000484 DOI:10.1371/journal.pdig.0000484
      PMID: 38620037
    • Proceeding / Abstract / Poster
      Abstract 7354: Proteogenomic and metabolomic characterization of acute myeloid leukemia
      Chu A, Hsiao Y, Deng Y, Wang C, Kyle J, Dou Y, Pino JC, Posso C, Henry L, Chen L, Li GX, Lih T-SM, Geffen Y, Yu F, Ding L, Omenn G, Kumar C, Dhanasekaran SM, Traer E, Tyner JW, Zhang H, Liu T, Gosline S, Zhang B, Chinnaiyan A, Nesvizhskii AI, Cieslik M. Cancer Research, 2024 Mar 22; 84 (6_Supplement): 7354 - 7354. DOI:10.1158/1538-7445.am2024-7354
    • Journal Article
      To do no harm - and the most good - with AI in health care.
      Goldberg CB, Adams L, Blumenthal D, Brennan PF, Brown N, Butte AJ, Cheatham M, deBronkart D, Dixon J, Drazen J, Evans BJ, Hoffman SM, Holmes C, Lee P, Manrai AK, Omenn GS, Perlin JB, Ramoni R, Sapiro G, Sarkar R, Sood H, Vayena E, Kohane IS, RAISE Consortium . Nat Med, 2024 Mar; 30 (3): 623 - 627. DOI:10.1038/s41591-024-02853-7
      PMID: 38388841
    • Journal Article
      Pan-cancer proteogenomics characterization of tumor immunity.
      Petralia F, Ma W, Yaron TM, Caruso FP, Tignor N, Wang JM, Charytonowicz D, Johnson JL, Huntsman EM, Marino GB, Calinawan A, Evangelista JE, Selvan ME, Chowdhury S, Rykunov D, Krek A, Song X, Turhan B, Christianson KE, Lewis DA, Deng EZ, Clarke DJB, Whiteaker JR, Kennedy JJ, Zhao L, Segura RL, Batra H, Raso MG, Parra ER, Soundararajan R, Tang X, Li Y, Yi X, Satpathy S, Wang Y, Wiznerowicz M, González-Robles TJ, Iavarone A, Gosline SJC, Reva B, Robles AI, Nesvizhskii AI, Mani DR, Gillette MA, Klein RJ, Cieslik M, Zhang B, Paulovich AG, Sebra R, Gümüş ZH, Hostetter G, Fenyö D, Omenn GS, Cantley LC, Ma'ayan A, Lazar AJ, Ceccarelli M, Wang P, Clinical Proteomic Tumor Analysis Consortium . Cell, 2024 Feb 29; 187 (5): 1255 - 1277.e27. DOI:10.1016/j.cell.2024.01.027
      PMID: 38359819
    • Journal Article
      To Do No Harm — and the Most Good — with AI in Health Care
      Goldberg CB, Adams L, Blumenthal D, Brennan PF, Brown N, Butte AJ, Cheatham M, deBronkart D, Dixon J, Drazen J, Evans BJ, Hoffman SM, Holmes C, Lee P, Manrai AK, Omenn GS, Perlin JB, Ramoni R, Sapiro G, Sarkar R, Sood H, Vayena E, Kohane IS. NEJM AI, 2024 Feb 22; 1 (3): DOI:10.1056/aip2400036
    Featured News & Stories Gil Omenn and Martha Darling
    News Release
    $25M gift builds U-M’s leadership in health care AI
    Gilbert S. Omenn, M.D., Ph.D., and his wife, Martha A. Darling, have made a generous gift of $25 million to the Department of Computational Medicine and Bioinformatics (DCMB) within the University of Michigan Medical School.
    Department News
    Gilbert S. Omenn, MD, PhD, receives the 5th Catherine E. Costello Lifetime Achievement Award
    Gilbert S. Omenn, MD, PhD, receives the 5th Catherine E. Costello Lifetime Achievement Award for medical research in the domain of proteomics
    Department News
    Automated open-source program improves performance in creating high-fidelity stable folds for de novo protein design
    Automated open-source program improves performance in creating high-fidelity stable folds for de novo protein design