Mats Ljungman, PhD
Professor of Radiation Oncology, Medical School
Professor of Environmental Health Sciences, School of Public Health
[email protected]

Available to mentor

Mats Ljungman, PhD
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    About

    Dr. Ljungman has a long-standing interest in carcinogenesis, radiation biology, DNA damage responses and regulation of transcription. A major goal of the lab is to elucidate basic mechanisms that ultimately could help better understand human diseases and in the development of improved therapeutics. The Ljungman lab has developed the Bru-seq technology platform to assess nascent RNA synthesis and stability in cells as well as splicing kinetics, transcription elongation rates and the mapping of transcription start sites and enhancers. These techniques provide novel information about the transcription process that cannot be obtained with traditional steady-state RNA-based approaches. The Ljungman lab is participating in ENCODE 4 as a Mapping Center.

    Qualifications
    • Postdoctoral fellow
      Stanford University, United States, 1994
    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Rogel Cancer Center
    • Center Member
      Precision Health Initiative
    Research Overview

    With the Bru-seq technology platform, the Ljungman lab are exploring many basic biological pathways involved in DNA damage and repair, acute cellular responses, epigenetics, differentiation, aging, cancer, neurodegenerative diseases such as ALS and autism. They are also collaborating with medicinal chemists to interrogate mechanisms of action of novel therapeutic drugs and are developing specific inhibitors of the RNA exosome as cancer therapeutic drugs. With the Bru-seq techniques, the Ljungman lab collaborates with many labs at the university and from over 10 different countries. The Ljungman lab has also developed a CRISPR-based precision approach called "KLIPP" for specific targeting of cancer cells without affecting normal cells. The CRISPR reagents will target structural variants that are unique to the tumor cells.

    Recent Publications See All Publications
    • Presentation
      Using CRISPR to Target Cancer
      Ljungman M. 2024 Nov 10;
    • Journal Article
      PSP205, a Novel Phenyl Sulfonyl Piperidine, Induces Apoptotic Cell Death in Colon Cancer by Modulating Coat Protein Complex-Mediated Vesicle Trafficking
      Samanta S, Roy J, Debnath B, Ljungman M, Neamati N. ACS Pharmacology and Translational Science, 2025 Apr 11; 8 (4): 1072 - 1086. DOI:10.1021/acsptsci.4c00617
    • Presentation
      KLIPP - Using CRISPR to Target Cancer
      Ljungman M. 2024 Nov 10;
    • Preprint
      IL-1 signaling enrichment in inflammatory skin disease loci with higher-risk allele frequencies in African ancestry.
      Tsoi L, Dong Y, Patrick M, Sarkar M, Zhang H, Bogle R, Zhang Z, Dand N, Paulsen M, Ljungman M, Betz RC, Petukhova L, Christiano A, Simpson M, Modlin R, Khanna D, Barker J, Budunova I, Gharaee-Kermani M, Billi A, Elder J, Kahlenberg JM, Gudjonsson J. 2025 Jan 23; DOI:10.21203/rs.3.rs-5724270/v1
      PMID: 39975900
    • Preprint
      An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.
      Moore JE, Pratt HE, Fan K, Phalke N, Fisher J, Elhajjajy SI, Andrews G, Gao M, Shedd N, Fu Y, Lacadie MC, Meza J, Ganna M, Choudhury E, Swofford R, Farrell NP, Pampari A, Ramalingam V, Reese F, Borsari B, Yu M, Wattenberg E, Ruiz-Romero M, Razavi-Mohseni M, Xu J, Galeev T, Beer MA, Guigó R, Gerstein M, Engreitz J, Ljungman M, Reddy TE, Snyder MP, Epstein CB, Gaskell E, Bernstein BE, Dickel DE, Visel A, Pennacchio LA, Mortazavi A, Kundaje A, Weng Z. 2024 Dec 26; DOI:10.1101/2024.12.26.629296
      PMID: 39763870
    • Journal Article
      STK19 facilitates the clearance of lesion-stalled RNAPII during transcription-coupled DNA repair
      van den Heuvel D, Rodríguez-Martínez M, van der Meer PJ, Nieto Moreno N, Park J, Kim HS, van Schie JJM, Wondergem AP, D'Souza A, Yakoub G, Herlihy AE, Kashyap K, Boissière T, Walker J, Mitter R, Apelt K, de Lint K, Kirdök I, Ljungman M, Wolthuis RMF, Cramer P, Schärer OD, Kokic G, Svejstrup JQ, Luijsterburg MS. Cell, 2024 Dec 12; 187 (25): 7107 - 7125.e25. DOI:10.1016/j.cell.2024.10.018
      PMID: 39547229
    • Journal Article
      PHF6 cooperates with SWI/SNF complexes to facilitate transcriptional progression
      Mittal P, Myers JA, Carter RD, Radko-Juettner S, Malone HA, Rosikiewicz W, Robertson AN, Zhu Z, Narayanan IV, Hansen BS, Parrish M, Bhanu NV, Mobley RJ, Rehg JE, Xu B, Drosos Y, Pruett-Miller SM, Ljungman M, Garcia BA, Wu G, Partridge JF, Roberts CWM. Nature Communications, 2024 Dec 1; 15 (1): DOI:10.1038/s41467-024-51566-5
      PMID: 39181868
    • Preprint
      Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote Ovarian Cancer Malignancy
      Mehta G, Horst E, Cotter L, Bonini M, Novak C, Treacher N, Zhang Y, Jackson Z, Narayanan IV, Wuchu F, Nenwani M, Fischer Z, Sunshine A, Lin Z, Tran L, Nagrath D, Ljungman M, Maturen K, DiFeo A, Nordsletten D. 2024 Nov 28; Springer Science and Business Media LLC, DOI:10.21203/rs.3.rs-5160301/v2