Steven E Harte, PhD
Ann Arbor, MI 48105
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About
Dr. Steven Harte
Associate Professor of Anesthesiology and Internal Medicine
Associate Director, Chronic Pain and Fatigue Research Center
Dr. Harte is a pain neuroscientist at the University of Michigan Medical School with over 25 years of experience advancing the understanding and treatment of chronic pain through innovative research and education. His NIH-funded research program employs a multidisciplinary approach—integrating preclinical models, psychophysics, inflammatory biomarkers, patient-reported outcomes, wearable technology, and functional brain imaging—to investigate chronic pain mechanisms and develop novel analgesic treatments. His specialized research interests include multisensory amplification and neural integration, neural-immune interface in chronic pain, endo-/cannabinoid and psychedelic analgesics, influence of built and natural environments on pain perception, pain affect, and mechanisms of pain modulation.
Dr. Harte has contributed to several major national pain research initiatives, including the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network, the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN), the HEAL BACPAC and BEST initiatives, and the AURORA Study on trauma, where he led multi-site quantitative sensory testing development. At the University of Michigan, he holds faculty affiliations with the Neuroscience Graduate Program, Michigan Neuroscience Institute, Opioid Research Institute, Sensory Science Initiative, and Michigan Psychedelic Center (M-PsyC). He serves as Director of the Postdoctoral T32 in Translational Science at the Michigan Institute for Clinical and Health Research (MICHR) and Co-Director of the HEAL National K12 Clinical Pain Career Development Program.
Committed to translating research into practical solutions, Dr. Harte co-founded Arbor Medical Innovations, where he serves as Chief Scientific Officer. His work in developing novel medical devices, research technologies, and eHealth applications has resulted in multiple patents related to pain measurement and wearable technology, furthering his mission to improve the lives of individuals suffering from chronic pain.
Links
Chronic Pain and Fatigue Research Center Department of Anesthesiology Neuroscience Graduate Program HEAL National K12 Michigan Institute of Clinical and Health Research Opioid Research Institute Michigan Psychedelic Center (M-PsyC) Arbor Medical Innovations
Center Memberships
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Center MemberOpioid Research Institute
Research Overview
- Quantitative sensory testing and multisensory sensitivity
- Preclinical pain assessment
- Functional and chemical neuroimaging
- Neuropsychopharmacology
- Neural-Immune interactions
- Consciousness neuroscience
- Cannabinoids/Endocannabinoids
- Environmental influences on pain
- Biomedical technology development
Recent Publications
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Lenert ME, Smith T, Hidalgo-Lopez E, Portengen CM, Harte SE, Beltz AM, Schrepf A, Kaplan CM. Lancet Child Adolesc Health, 2026 Oct; 10 (10): 710 - 718.Journal ArticlePremenarche risk factors for future dysmenorrhoea: a prospective cohort study.
DOI:10.1016/S2352-4642(26)00165-3 PMID: 42679828 -
McLain N, Kaplan C, Harte S, Lenert M, Evanski J, Hidalgo-Lopez E, Egan M, Ichesco E, Harris RE, Kutch J, Clauw D, As-Sanie S, Schrepf A. 2026 Sep 30; openRxiv,PreprintFunctional Connectivity Differences Underly Variable Centralized Symptom Relief After Hysterectomy
DOI:10.64898/2026.09.26.754679 -
McLain N, Kaplan C, Harte S, Schrepf A. 2026 Sep 25;PreprintConcordance between the fast and efficient mixed-effects algorithm (FEMA) and conventional mixed-effects modeling for whole-brain connectivity in longitudinal chronic pain.
DOI:10.64898/2026.09.20.753017 PMID: 42818179 -
McLain NJ, Kaplan CM, Naliboff BD, Rodriguez L, Moldwin R, Williams DA, Farrar JT, Harris RE, Spitznagle T, Clauw D, Clemens JQ, Harte SE, Kutch JJ, Schrepf A. Pain, 2026 Sep 29;Journal ArticleDistinct connectivity patterns subserve 2 dimensions of the chronic pain experience
DOI:10.1097/j.pain.0000000000004114 -
Lenert ME, Pontari M, Hildago-Lopez E, Clemens JQ, Kaplan CM, Harte SE, Schrepf A. Brain, Behavior, and Immunity, 2026 Sep 28; 107032 - 107032.Journal ArticleSex-biased toll-like receptor 4 signaling in nociplastic pelvic pain
DOI:10.1016/j.bbi.2026.107032 -
Pouyan N, Kaplan CM, Larkin TE, Ichesco E, Egan MK, Preller KH, Dunworth JB, Harris RE, Mashour GA, Harte SE. Communications Biology, 2026 Sep 1;Journal ArticleSubanesthetic nitrous oxide alters large-scale network organization and insula connectivity during visual stimulation
DOI:10.1038/s42003-026-10838-0 -
Frey-Law LA, Berardi G, Ansari B, Liu Y, Satpathy-Horton B, Sluka KA, Vance CG, Dailey DL, McCarthy RJ, Wager TD, Lindquist MA, Harte SE. 2026 Aug 19; medRxiv,PreprintPain and Pain Sensitivity Assessments in the Acute to Chronic Pain Signatures (A2CPS) Program
DOI:10.64898/2026.08.14.26360457 -
Mellen EJ, Poplin T, Jovanovic T, Rowland GE, House SL, Beaudoin FL, An X, Stevens JS, Neylan TC, Clifford GD, Linnstaedt SD, Germine LT, Rauch SL, Haran JP, Storrow AB, Lewandowski C, Musey PI, Hendry PL, Sheikh S, Jones CW, Punches BE, Swor RA, Hudak LA, Pascual JL, Seamon MJ, Pearson C, Peak DA, Domeier RM, Rathlev NK, O'Neil BJ, Sanchez LD, Bruce SE, Harte SE, Kessler RC, Koenen KC, McLean SA, Harnett NG, Ressler KJ. JAMA Psychiatry, 2026 Jul 29;Journal ArticlePrior Sexual Violence, PTSD Symptoms, and Recovery Trajectories After New Trauma.
DOI:10.1001/jamapsychiatry.2026.2219 PMID: PMC13420162
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