Associate Chair
Department of Biological Chemistry
Professor of Biological Chemistry
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220B MSRB III
Ann Arbor, MI 48109
[email protected]
1150 W. Medical Center Dr., 4220B MSRB III
Ann Arbor, MI 48109
Available to mentor
Patrick O'Brien
Professor
Our lab focuses on molecular mechanisms of DNA repair, replication, and mutagenesis using biochemical, biophysical, genetic and cellular approaches. We are interested in basic mechanisms that preserve genetic integrity in normal tissues and in the abnormalities that drive cancer, immunodeficiency, and aging.
O'Brien Lab
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Center MemberRogel Cancer Center
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Moritz L, Schon SB, Rabbani M, Sheng Y, Agrawal R, Glass-Klaiber J, Sultan C, Camarillo JM, Clements J, Baldwin MR, Diehl AG, Boyle AP, O'Brien PJ, Ragunathan K, Hu Y-C, Kelleher NL, Nandakumar J, Li JZ, Orwig KE, Redding S, Hammoud SS. Nat Struct Mol Biol, 2023 Aug; 30 (8): 1077 - 1091.Journal ArticleSperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1.
DOI:10.1038/s41594-023-01033-4 PMID: 37460896 -
McNally JR, Ames AM, Admiraal SJ, O'Brien PJ. Nucleic Acids Res, 2023 Jan 25; 51 (2): 796 - 805.Journal ArticleHuman DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity.
DOI:10.1093/nar/gkac1263 PMID: 36625284 -
Kaplanis J, Ide B, Sanghvi R, Neville M, Danecek P, Coorens T, Prigmore E, Short P, Gallone G, McRae J, Genomics England Research Consortium , Carmichael J, Barnicoat A, Firth H, O'Brien P, Rahbari R, Hurles M. Nature, 2022 May; 605 (7910): 503 - 508.Journal ArticleGenetic and chemotherapeutic influences on germline hypermutation.
DOI:10.1038/s41586-022-04712-2 PMID: 35545669 -
Ray P, Nancarrow DJ, Ferrer-Torres D, Wang Z, San Martinho M, Hinton T, Wu JH, Wu A, Turgeon DK, Hammer MA, Dame MK, Lawrence TS, O'Brien PJ, Spence JR, Beer DG, Ray D. Cell Mol Gastroenterol Hepatol, 2022 13 (1): 129 - 149.Journal ArticleUBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
DOI:10.1016/j.jcmgh.2021.08.003 PMID: 34416429 -
Jurkiw TJ, Tumbale PP, Schellenberg MJ, Cunningham-Rundles C, Williams RS, O'Brien PJ. Nucleic Acids Res, 2021 Feb 22; 49 (3): 1619 - 1630.Journal ArticleLIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
DOI:10.1093/nar/gkaa1297 PMID: 33444456 -
Baldwin MR, Admiraal SJ, O'Brien PJ. J Biol Chem, 2020 May 22; 295 (21): 7317 - 7326.Journal ArticleTransient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB.
DOI:10.1074/jbc.RA120.013517 PMID: 32284330 -
Thelen AZ, O'Brien PJ. J Biol Chem, 2020 Feb 7; 295 (6): 1685 - 1693.Journal ArticleRecognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.
DOI:10.1074/jbc.RA119.011459 PMID: 31882538 -
Tumbale PP, Jurkiw TJ, Schellenberg MJ, Riccio AA, O'Brien PJ, Williams RS. Nat Commun, 2019 Nov 28; 10 (1): 5431Journal ArticleTwo-tiered enforcement of high-fidelity DNA ligation.
DOI:10.1038/s41467-019-13478-7 PMID: 31780661
Department News
Biological Chemistry PhD student Jenna Veenstra of the O'Brien lab at U-M Medical School defends her doctoral dissertation.
Department News
PhD student David Beier of the O'Brien lab at U-M Medical School wins award at DNA repair meeting
