Patrick O'Brien
Associate Chair, Department of Biological Chemistry
Professor of Biological Chemistry
Department of Biological Chemistry
1150 W. Medical Center Dr., 4220B MSRB III
Ann Arbor, MI 48109
[email protected]

Available to mentor

Patrick O'Brien
  • About
  • Center Memberships
  • Recent Publications
  • About

    Our lab focuses on molecular mechanisms of DNA repair, replication, and mutagenesis using biochemical, biophysical, genetic and cellular approaches. We are interested in basic mechanisms that preserve genetic integrity in normal tissues and in the abnormalities that drive cancer, immunodeficiency, and aging.

    Center Memberships
    • Center Member
      Rogel Cancer Center
    Recent Publications See All Publications
    • Journal Article
      Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1.
      Moritz L, Schon SB, Rabbani M, Sheng Y, Agrawal R, Glass-Klaiber J, Sultan C, Camarillo JM, Clements J, Baldwin MR, Diehl AG, Boyle AP, O'Brien PJ, Ragunathan K, Hu Y-C, Kelleher NL, Nandakumar J, Li JZ, Orwig KE, Redding S, Hammoud SS. Nat Struct Mol Biol, 2023 Aug; 30 (8): 1077 - 1091. DOI:10.1038/s41594-023-01033-4
      PMID: 37460896
    • Journal Article
      Human DNA ligases I and III have stand-alone end-joining capability, but differ in ligation efficiency and specificity.
      McNally JR, Ames AM, Admiraal SJ, O'Brien PJ. Nucleic Acids Res, 2023 Jan 25; 51 (2): 796 - 805. DOI:10.1093/nar/gkac1263
      PMID: 36625284
    • Journal Article
      Genetic and chemotherapeutic influences on germline hypermutation.
      Kaplanis J, Ide B, Sanghvi R, Neville M, Danecek P, Coorens T, Prigmore E, Short P, Gallone G, McRae J, Genomics England Research Consortium , Carmichael J, Barnicoat A, Firth H, O'Brien P, Rahbari R, Hurles M. Nature, 2022 May; 605 (7910): 503 - 508. DOI:10.1038/s41586-022-04712-2
      PMID: 35545669
    • Journal Article
      UBCH5 Family Members Differentially Impact Stabilization of Mutant p53 via RNF128 Iso1 During Barrett's Progression to Esophageal Adenocarcinoma.
      Ray P, Nancarrow DJ, Ferrer-Torres D, Wang Z, San Martinho M, Hinton T, Wu JH, Wu A, Turgeon DK, Hammer MA, Dame MK, Lawrence TS, O'Brien PJ, Spence JR, Beer DG, Ray D. Cell Mol Gastroenterol Hepatol, 2022 13 (1): 129 - 149. DOI:10.1016/j.jcmgh.2021.08.003
      PMID: 34416429
    • Journal Article
      LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
      Jurkiw TJ, Tumbale PP, Schellenberg MJ, Cunningham-Rundles C, Williams RS, O'Brien PJ. Nucleic Acids Res, 2021 Feb 22; 49 (3): 1619 - 1630. DOI:10.1093/nar/gkaa1297
      PMID: 33444456
    • Journal Article
      Transient kinetic analysis of oxidative dealkylation by the direct reversal DNA repair enzyme AlkB.
      Baldwin MR, Admiraal SJ, O'Brien PJ. J Biol Chem, 2020 May 22; 295 (21): 7317 - 7326. DOI:10.1074/jbc.RA120.013517
      PMID: 32284330
    • Journal Article
      Recognition of 1,N2-ethenoguanine by alkyladenine DNA glycosylase is restricted by a conserved active-site residue.
      Thelen AZ, O'Brien PJ. J Biol Chem, 2020 Feb 7; 295 (6): 1685 - 1693. DOI:10.1074/jbc.RA119.011459
      PMID: 31882538
    • Journal Article
      Two-tiered enforcement of high-fidelity DNA ligation.
      Tumbale PP, Jurkiw TJ, Schellenberg MJ, Riccio AA, O'Brien PJ, Williams RS. Nat Commun, 2019 Nov 28; 10 (1): 5431 DOI:10.1038/s41467-019-13478-7
      PMID: 31780661