1000 Wall Street
Ann Arbor, MI 48105
Available to mentor
Dr Fort is a trained neuroscientist focusing on the neuroretina and the neuro-glial interaction. Dr Fort did his undergraduate studies at the Claude Bernard University in Lyon (France) before a master’s degree in neuroscience and a Doctorate in Living Sciences from the Louis Pasteur University in Strasbourg (France) with Dr Alvaro Rendon and Pr Jose Sahel at the Vision Institute in Paris (France). During his Ph.D., he uncovered unknown key roles of one of the dystrophin isoforms called Dp71, one as a key player in the regulation of retinal homeostasis by Müller glial cells, and the other as a critical protein for maintenance of lens transparency.
Following his Ph.D., Dr Fort pursued is training at the Penn State University (Hershey, PA) where he continued to gain knowledge of retinal physiology and how it is affected by metabolic and neurodegenerative diseases. As he joined the laboratory of Dr. Gardner for his postdoctoral fellowship, he started studying how diabetes affects retinal metabolism and specifically, protein synthesis. This led to the identification of novel mechanisms of regulation of protein synthesis, specific to the retina and different from other insulin-sensitive tissues. During this time, he also identified previously unknown proteome changes, including effects on intrinsic protective mechanisms critical for cellular survival, using proteomic-based discovery approaches. Dr Fort was recruited by the University of Michigan Kellogg Eye Center in December 2010 as an assistant professor of the department of Ophthalmology and Visual Science, where he focuses on the function and regulation of these intrinsic protective mechanisms in acute and chronic retinal neurodegenerative disorders. Dr. Fort later joined the program of Cellular and Molecular Biology (CMB) as well as the department of molecular and Integrative Physiology (MIP) and the Neuroscience graduate program (NGP) of the University of Michigan in which he participates in recruitment and training of graduate students.
https://sites.google.com/a/umich.edu/patrice-fort-lab/home?authuser=0 https://medicine.umich.edu/dept/ophthalmology/patrice-e-fort-phd-ms#websites
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FellowshipPenn State Hershey College of Medicine, Ophthalmology, 2008
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Center MemberCaswell Diabetes Institute
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Center MemberGlobal REACH
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Center MemberCenter for Cell Plasticity and Organ Design
The main research interest of Dr. Fort's laboratory are:
1. Intrinsic retinal neuron survival mechanisms
2. Retinal glial cells implications in pathological and normal retinal functions
3. Hsp/Crystallin protein functions in the retina
4. Signaling pathways regulation
5. Regulation of the retinal inflammatory response
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Besirli CG, Nath M, Yao J, Pawar M, Myers AM, Zacks D, Fort PE. Neurol Int, 2024 Aug 26; 16 (5): 905 - 917.Journal ArticleHSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation.
DOI:10.3390/neurolint16050068 PMID: 39311341 -
Grenot M, Roman A, Manon V, Morel A-L, Patrice F, Arthaud S, Libourel P-A, Christelle P. Sleep, 2024 Aug 9;Journal ArticleMajor Alteration Of Motor Control During Rem Sleep In Mice Models Of Sleep Disorders.
DOI:10.1093/sleep/zsae178 PMID: 39121093 -
Lin C-H, Wu M-R, Tanasa B, Prakhar P, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. bioRxiv,PreprintInduction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage
DOI:10.1101/2024.06.10.598362 -
Channa R, Wolf RM, Simo R, Brigell M, Fort P, Curcio C, Lynch S, Verbraak F, Abramoff MD, Diabetic Retinal Neurodegeneration and Macular Edema working group of the Mary Tyler Moore Vision Initiative’s Diabetic Retinal Disease Staging Update Project . Ophthalmol Sci, 2024 4 (3): 100420Journal ArticleA New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema.
DOI:10.1016/j.xops.2023.100420 PMID: 38284099 -
Luppi P-H, Chancel A, Malcey J, Cabrera S, Fort P, Maciel RM. Sleep Med Rev, 2024 Apr; 74: 101907Journal ArticleWhich structure generates paradoxical (REM) sleep: The brainstem, the hypothalamus, the amygdala or the cortex?
DOI:10.1016/j.smrv.2024.101907 PMID: 38422648 -
Chancel A, Maciel RM, Fort P, Luppi P-H. Médecine du Sommeil, 2024 Mar; 21 (1): 18Journal ArticleCartographie des populations neuronales actives pendant l’éveil et le sommeil paradoxal (REM) dans l’hypothalamus chez la souris transgénique TRAP2
DOI:10.1016/j.msom.2023.12.044 -
Malcey J, Duval B, Maciel R, Chancel A, Cabrera S, Fort P, Luppi P-H. Médecine du Sommeil, 2024 Mar; 21 (1): 19Journal ArticleLe rôle de l’activité cérébrale pendant le sommeil paradoxal (SP) dans un modèle de dépression chez la souris
DOI:10.1016/j.msom.2023.12.046 -
Chancel A, Fort P, Luppi P-H. Sleep, 2024 Mar 11; 47 (3):Journal ArticleThe role of the hypothalamic Lhx6 GABAergic neurons in REM sleep control.
DOI:10.1093/sleep/zsad331 PMID: 38159085