
1000 Wall Street
Ann Arbor, MI 48105
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Dr Fort is a trained neuroscientist focusing on the neuroretina and the neuro-glial interaction. Dr Fort did his undergraduate studies at the Claude Bernard University in Lyon (France) before a master’s degree in neuroscience and a Doctorate in Living Sciences from the Louis Pasteur University in Strasbourg (France) with Dr Alvaro Rendon and Pr Jose Sahel at the Vision Institute in Paris (France). During his Ph.D., he uncovered unknown key roles of one of the dystrophin isoforms called Dp71, one as a key player in the regulation of retinal homeostasis by Müller glial cells, and the other as a critical protein for maintenance of lens transparency.
Following his Ph.D., Dr Fort pursued is training at the Penn State University (Hershey, PA) where he continued to gain knowledge of retinal physiology and how it is affected by metabolic and neurodegenerative diseases. As he joined the laboratory of Dr. Gardner for his postdoctoral fellowship, he started studying how diabetes affects retinal metabolism and specifically, protein synthesis. This led to the identification of novel mechanisms of regulation of protein synthesis, specific to the retina and different from other insulin-sensitive tissues. During this time, he also identified previously unknown proteome changes, including effects on intrinsic protective mechanisms critical for cellular survival, using proteomic-based discovery approaches. Dr Fort was recruited by the University of Michigan Kellogg Eye Center in December 2010 as an assistant professor of the department of Ophthalmology and Visual Science, where he focuses on the function and regulation of these intrinsic protective mechanisms in acute and chronic retinal neurodegenerative disorders. Dr. Fort later joined the program of Cellular and Molecular Biology (CMB) as well as the department of molecular and Integrative Physiology (MIP) and the Neuroscience graduate program (NGP) of the University of Michigan in which he participates in recruitment and training of graduate students.
https://sites.google.com/a/umich.edu/patrice-fort-lab/home?authuser=0 https://medicine.umich.edu/dept/ophthalmology/patrice-e-fort-phd-ms#websites
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FellowshipPenn State Hershey College of Medicine, Ophthalmology, 2008
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Center MemberCaswell Diabetes Institute
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Center MemberGlobal REACH
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Center MemberCenter for Cell Plasticity and Organ Design
The main research interest of Dr. Fort's laboratory are:
1. Intrinsic retinal neuron survival mechanisms
2. Retinal glial cells implications in pathological and normal retinal functions
3. Hsp/Crystallin protein functions in the retina
4. Signaling pathways regulation
5. Regulation of the retinal inflammatory response
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2025 Jun 16;PresentationThe Mary Tyler Moore Vision Initiative Biorepository and Resource Centre: From fundus to cellular analysis of retinal organization in diabetic retinal disease
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Rose L, Zahid AN, Piilgaard L, Egebjerg C, Sørensen FL, Andersen M, Radovanovic T, Tsopanidou A, Bastianini S, Berteotti C, Martire VL, Borsa M, Tisdale RK, Sun Y, Nedergaard M, Silvani A, Zoccoli G, Adamantidis A, Kilduff TS, Sakai N, Nishino S, Arthaud S, Peyron C, Fort P, Mørup M, Mignot E, Kornum BR. SLEEP Advances, 2025 May 11; zpaf025Journal ArticleProbability Estimation of Narcolepsy Type 1 in DTA mice using Unlabeled EEG and EMG Data
DOI:10.1093/sleepadvances/zpaf025 -
Comperat L, Leclair-Visonneau L, Ricordeau F, Bastuji H, Fort P, Simor P, Nicolas J, Peter-Derex L. Médecine du Sommeil, 2025 Mar 1; 22 (1): 61Journal ArticleAltérations de la microstructure du sommeil paradoxal dans le TCSP isolé et associé à la maladie de Parkinson
DOI:10.1016/j.msom.2025.01.083 -
Chancel A, Fort P, Luppi P-H. Médecine du Sommeil, 2025 Mar 1; 22 (1): 84Journal ArticleIdentification des neurones hypothalamiques activés pendant l’éveil, le sommeil lent et le rebond de sommeil paradoxal chez la souris TRAP2-red
DOI:10.1016/j.msom.2025.01.135 -
Duval B, Arthaud S, Malcey J, Chancel A, Luppi P-H, Fort P. Médecine du Sommeil, 2025 Mar 1; 22 (1): 85Journal ArticleNouveau modèle expérimental de trouble du comportement en sommeil paradoxal (TCSP) chez la souris sauvage
DOI:10.1016/j.msom.2025.01.137 -
Maciel R, Malcey J, Chancel A, Brunel T, Fort P, Queiroz CM, Luppi P-H. 2025 Feb 1; bioRxiv,PreprintDrug-induced versus non-pharmacological wakefulness: similar or different states? A whole brain analysis in TRAP2 transgenic mice
DOI:10.1101/2025.01.29.635430 -
Sluzala ZB, Hamati A, Fort PE. Cells, 2025 Jan 17; 14 (2):Journal ArticleKey Role of Phosphorylation in Small Heat Shock Protein Regulation via Oligomeric Disaggregation and Functional Activation.
DOI:10.3390/cells14020127 PMID: PMC11764305 -
Nicolas J, Comperat L, Fort P, Cheylus A, Ricordeau F, Bastuji H, Simor P, Leclair-Visonneau L, Peter-Derex L. 2025 Jan 4; medRxiv,PreprintREM sleep microstructure alterations in REM sleep behavior disorder: beyond muscle tone
DOI:10.1101/2025.01.02.24319683