1000 Wall Street
Ann Arbor, MI 48105
Available to mentor
Dr Fort is a trained neuroscientist focusing on the neuroretina and the neuro-glial interaction. Dr Fort did his undergraduate studies at the Claude Bernard University in Lyon (France) before a master’s degree in neuroscience and a Doctorate in Living Sciences from the Louis Pasteur University in Strasbourg (France) with Dr Alvaro Rendon and Pr Jose Sahel at the Vision Institute in Paris (France). During his Ph.D., he uncovered unknown key roles of one of the dystrophin isoforms called Dp71, one as a key player in the regulation of retinal homeostasis by Müller glial cells, and the other as a critical protein for maintenance of lens transparency.
Following his Ph.D., Dr Fort pursued is training at the Penn State University (Hershey, PA) where he continued to gain knowledge of retinal physiology and how it is affected by metabolic and neurodegenerative diseases. As he joined the laboratory of Dr. Gardner for his postdoctoral fellowship, he started studying how diabetes affects retinal metabolism and specifically, protein synthesis. This led to the identification of novel mechanisms of regulation of protein synthesis, specific to the retina and different from other insulin-sensitive tissues. During this time, he also identified previously unknown proteome changes, including effects on intrinsic protective mechanisms critical for cellular survival, using proteomic-based discovery approaches. Dr Fort was recruited by the University of Michigan Kellogg Eye Center in December 2010 as an assistant professor of the department of Ophthalmology and Visual Science, where he focuses on the function and regulation of these intrinsic protective mechanisms in acute and chronic retinal neurodegenerative disorders. Dr. Fort later joined the program of Cellular and Molecular Biology (CMB) as well as the department of molecular and Integrative Physiology (MIP) and the Neuroscience graduate program (NGP) of the University of Michigan in which he participates in recruitment and training of graduate students.
https://sites.google.com/a/umich.edu/patrice-fort-lab/home?authuser=0 https://medicine.umich.edu/dept/ophthalmology/patrice-e-fort-phd-ms#websites
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FellowshipPenn State Hershey College of Medicine, Ophthalmology, 2008
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Center MemberCaswell Diabetes Institute
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Center MemberGlobal REACH
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Center MemberCenter for Cell Plasticity and Organ Design
The main research interest of Dr. Fort's laboratory are:
1. Intrinsic retinal neuron survival mechanisms
2. Retinal glial cells implications in pathological and normal retinal functions
3. Hsp/Crystallin protein functions in the retina
4. Signaling pathways regulation
5. Regulation of the retinal inflammatory response
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Lin C-H, Wu M-R, Tanasa B, Prakhar P, Deng B, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. Diabetes, 2024 Oct 24;Journal ArticleInduction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage.
DOI:10.2337/db24-0199 PMID: 39446557 -
Fort P. 2024 Oct;PresentationAlphaA-crystallin and the regulation of the metabolic-stress induced gliotic response.
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Besirli CG, Nath M, Yao J, Pawar M, Myers AM, Zacks D, Fort PE. Neurol Int, 2024 Aug 26; 16 (5): 905 - 917.Journal ArticleHSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation.
DOI:10.3390/neurolint16050068 PMID: 39311341 -
Lin C-H, Wu M-R, Tanasa B, Prakhar P, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. bioRxiv,PreprintInduction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage
DOI:10.1101/2024.06.10.598362 -
Channa R, Wolf RM, Simo R, Brigell M, Fort P, Curcio C, Lynch S, Verbraak F, Abramoff MD, Diabetic Retinal Neurodegeneration and Macular Edema working group of the Mary Tyler Moore Vision Initiative’s Diabetic Retinal Disease Staging Update Project . Ophthalmol Sci, 2024 4 (3): 100420Journal ArticleA New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema.
DOI:10.1016/j.xops.2023.100420 PMID: 38284099 -
Laguna A, Peñuelas N, Gonzalez-Sepulveda M, Nicolau A, Arthaud S, Guillard-Sirieix C, Lorente-Picón M, Compte J, Miquel-Rio L, Xicoy H, Liu J, Parent A, Cuadros T, Romero-Giménez J, Pujol G, Giménez-Llort L, Fort P, Bortolozzi A, Carballo-Carbajal I, Vila M. bioRxiv,PreprintModelling human neuronal catecholaminergic pigmentation in rodents recapitulates age-related multisystem neurodegenerative deficits
DOI:10.1101/2023.08.08.552400 -
Torm MEW, Dorweiler TF, Fickweiler W, Levine SR, Fort PE, Sun JK, Gardner TW. J Diabetes Complications, 2023 Feb; 37 (2): 108386Journal ArticleFrontiers in diabetic retinal disease.
DOI:10.1016/j.jdiacomp.2022.108386 PMID: 36608490 -
Sluzala ZB, Garner AL, Fort PE. Biophysical Journal, 2023 Feb; 122 (3): 479aJournal ArticleUnveiling the mechanistic regulation of T148 phosphorylation-mediated neuroprotection by αA-crystallin
DOI:10.1016/j.bpj.2022.11.2564