Patrice E Fort
Associate Director
Department of Neuroscience Graduate Program
Associate Professor of Ophthalmology and Visual Sciences
Associate Professor of Molecular and Integrative Physiology
Department of Ophthalmology and Visual Sciences
1000 Wall Street
Ann Arbor, MI 48105
[email protected]

Available to mentor

Patrice E Fort
Associate Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr Fort is a trained neuroscientist focusing on the neuroretina and the neuro-glial interaction. Dr Fort did his undergraduate studies at the Claude Bernard University in Lyon (France) before a master’s degree in neuroscience and a Doctorate in Living Sciences from the Louis Pasteur University in Strasbourg (France) with Dr Alvaro Rendon and Pr Jose Sahel at the Vision Institute in Paris (France). During his Ph.D., he uncovered unknown key roles of one of the dystrophin isoforms called Dp71, one as a key player in the regulation of retinal homeostasis by Müller glial cells, and the other as a critical protein for maintenance of lens transparency.

    Following his Ph.D., Dr Fort pursued is training at the Penn State University (Hershey, PA) where he continued to gain knowledge of retinal physiology and how it is affected by metabolic and neurodegenerative diseases. As he joined the laboratory of Dr. Gardner for his postdoctoral fellowship, he started studying how diabetes affects retinal metabolism and specifically, protein synthesis. This led to the identification of novel mechanisms of regulation of protein synthesis, specific to the retina and different from other insulin-sensitive tissues. During this time, he also identified previously unknown proteome changes, including effects on intrinsic protective mechanisms critical for cellular survival, using proteomic-based discovery approaches. Dr Fort was recruited by the University of Michigan Kellogg Eye Center in December 2010 as an assistant professor of the department of Ophthalmology and Visual Science, where he focuses on the function and regulation of these intrinsic protective mechanisms in acute and chronic retinal neurodegenerative disorders. Dr. Fort later joined the program of Cellular and Molecular Biology (CMB) as well as the department of molecular and Integrative Physiology (MIP) and the Neuroscience graduate program (NGP) of the University of Michigan in which he participates in recruitment and training of graduate students.

    Links
    • https://sites.google.com/a/umich.edu/patrice-fort-lab/home?authuser=0
    • https://medicine.umich.edu/dept/ophthalmology/patrice-e-fort-phd-ms#websites
    Qualifications
    • Fellowship
      Penn State Hershey College of Medicine, Ophthalmology, 2008
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Global REACH
    • Center Member
      Center for Cell Plasticity and Organ Design
    Research Overview

    The main research interest of Dr. Fort's laboratory are:
    1. Intrinsic retinal neuron survival mechanisms
    2. Retinal glial cells implications in pathological and normal retinal functions
    3. Hsp/Crystallin protein functions in the retina
    4. Signaling pathways regulation
    5. Regulation of the retinal inflammatory response

    Recent Publications See All Publications
    • Journal Article
      HSPB4/CRYAA Protect Photoreceptors during Retinal Detachment in Part through FAIM2 Regulation.
      Besirli CG, Nath M, Yao J, Pawar M, Myers AM, Zacks D, Fort PE. Neurol Int, 2024 Aug 26; 16 (5): 905 - 917. DOI:10.3390/neurolint16050068
      PMID: 39311341
    • Journal Article
      Major Alteration Of Motor Control During Rem Sleep In Mice Models Of Sleep Disorders.
      Grenot M, Roman A, Manon V, Morel A-L, Patrice F, Arthaud S, Libourel P-A, Christelle P. Sleep, 2024 Aug 9; DOI:10.1093/sleep/zsae178
      PMID: 39121093
    • Preprint
      Induction of a Müller glial-specific protective pathway safeguards the retina from diabetes induced damage
      Lin C-H, Wu M-R, Tanasa B, Prakhar P, Davis AE, Li L, Xia A, Shan Y, Fort PE, Wang S. bioRxiv, DOI:10.1101/2024.06.10.598362
    • Journal Article
      A New Approach to Staging Diabetic Eye Disease: Staging of Diabetic Retinal Neurodegeneration and Diabetic Macular Edema.
      Channa R, Wolf RM, Simo R, Brigell M, Fort P, Curcio C, Lynch S, Verbraak F, Abramoff MD, Diabetic Retinal Neurodegeneration and Macular Edema working group of the Mary Tyler Moore Vision Initiative’s Diabetic Retinal Disease Staging Update Project . Ophthalmol Sci, 2024 4 (3): 100420 DOI:10.1016/j.xops.2023.100420
      PMID: 38284099
    • Journal Article
      Which structure generates paradoxical (REM) sleep: The brainstem, the hypothalamus, the amygdala or the cortex?
      Luppi P-H, Chancel A, Malcey J, Cabrera S, Fort P, Maciel RM. Sleep Med Rev, 2024 Apr; 74: 101907 DOI:10.1016/j.smrv.2024.101907
      PMID: 38422648
    • Journal Article
      Cartographie des populations neuronales actives pendant l’éveil et le sommeil paradoxal (REM) dans l’hypothalamus chez la souris transgénique TRAP2
      Chancel A, Maciel RM, Fort P, Luppi P-H. Médecine du Sommeil, 2024 Mar; 21 (1): 18 DOI:10.1016/j.msom.2023.12.044
    • Journal Article
      Le rôle de l’activité cérébrale pendant le sommeil paradoxal (SP) dans un modèle de dépression chez la souris
      Malcey J, Duval B, Maciel R, Chancel A, Cabrera S, Fort P, Luppi P-H. Médecine du Sommeil, 2024 Mar; 21 (1): 19 DOI:10.1016/j.msom.2023.12.046
    • Journal Article
      The role of the hypothalamic Lhx6 GABAergic neurons in REM sleep control.
      Chancel A, Fort P, Luppi P-H. Sleep, 2024 Mar 11; 47 (3): DOI:10.1093/sleep/zsad331
      PMID: 38159085