Randy J Seeley
Henry King Ransom Professor of Surgery
Professor of Surgery
Professor of Internal Medicine
Medical School
Professor of Nutritional Sciences
School of Public Health
Surgery
2800 Plymouth Rd
Ann Arbor, MI 48109
[email protected]

Available to mentor

Randy J Seeley
Professor
  • About
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  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    About

    Dr. Randy Seeley is the Henry King Ransom Endowed Professor of Surgery, Internal Medicine, and Nutritional Sciences at the University of Michigan School of Medicine. He also serves as the director of the NIH-funded Michigan Nutrition Obesity Research Center (MNORC). Before that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine. He also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before relocating to the University of Cincinnati in 1997 and then to the University of Michigan in 2014. He has published over 390 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation, and the New England Journal of Medicine. Collectively, this work has been cited more than 43,000 times and Dr. Seeley has a Scopus h-index of 103. He is the recipient of the 2003 Lilly Scientific Achievement Award from the Obesity Society given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree. He is also the co-recipient of the 2008 Ernst Oppenheimer Award from the Endocrine Society. This Award is the premier award to an investigator under the age of 45 in recognition of meritorious accomplishment in the field of basic or clinical endocrinology. He also received the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association. This award is presented to an individual medical researcher under age 45 who has made an outstanding contribution to diabetes research that demonstrates both originality and independence of thought.

    Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He served on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science. He currently serves as Senior Associate Editor for Diabetes.

    Dr. Seeley has also been sought after by companies trying to bring new therapies for obesity and diabetes to patients. He has served as a consultant or member of a Scientific Advisory Board for venture capital, medical device, pharmaceutical, and biotech companies such as Procter & Gamble, Johnson & Johnson, Novartis, Novo Nordisk, Eli Lilly, Merck, Takeda, Amylin, Angiochem, Zealand, Boehringer Ingelheim, Eisai, Janssen, Novartis, Sanofi, Kallyope, Scohia, Ironwood Pharmaceuticals, Zafgen, Gilead, Kintai, Ionis, Rewind Health, and Calibrate. His laboratory has worked on numerous collaborative research projects with industry partners including Ethicon Endo-Surgery, Procter & Gamble, Pfizer, Novo Nordisk, Amylin, Roche, Merck, Zafgen, Zealand, Mannkind, Boehringer Ingelheim, Easai, Givaudan, AstraZeneca, Ablaris, Kintai, Energesis, Ionis, Fractyl, Amgen, Glyscend, Bullfrog AI and Eli Lilly. He has also been sought for numerous media interviews about obesity therapy including in the New York Times, Wall Street Journal, STAT News, and PBS’s Nova.

    Links
    Qualifications
    • NRSA Post-Doctoral Fellowship
      University of Washington, Psychology, 1997
    • Ph.D.
      University of Pennsylvania, 2018
    • BA
      Grinnell College, 1989
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism with a focus on new treatment strategies. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Recent Publications See All Publications
    • Journal Article
      Glucose-dependent insulinotropic polypeptide (GIP)
      Müller TD, Adriaenssens A, Ahrén B, Blüher M, Birkenfeld AL, Campbell JE, Coghlan MP, D'Alessio D, Deacon CF, DelPrato S, Douros JD, Drucker DJ, Figueredo Burgos NS, Flatt PR, Finan B, Gimeno RE, Gribble FM, Hayes MR, Hölscher C, Holst JJ, Knerr PJ, Knop FK, Kusminski CM, Liskiewicz A, Mabilleau G, Mowery SA, Nauck MA, Novikoff A, Reimann F, Roberts AG, Rosenkilde MM, Samms RJ, Scherer PE, Seeley RJ, Sloop KW, Wolfrum C, Wootten D, DiMarchi RD, Tschöp MH. Molecular Metabolism, 2025 May 1; 95: DOI:10.1016/j.molmet.2025.102118
      PMID: 40024571
    • Journal Article
      Semaglutide and bariatric surgery induce distinct changes in the composition of mouse white adipose tissue
      Emont MP, Essene AL, Gulko A, Bozadjieva-Kramer N, Jacobs C, Nagesh S, Seeley RJ, Tsai LT, Rosen ED. Molecular Metabolism, 2025 May 1; 95: DOI:10.1016/j.molmet.2025.102126
    • Journal Article
      Specific loss of GIPR signaling in GABAergic neurons enhances GLP-1R agonist-induced body weight loss
      Wean J, Kowalsky AH, Laker R, Will S, Drucker DJ, Rhodes CJ, Seeley RJ. Molecular Metabolism, 2025 May 1; 95: DOI:10.1016/j.molmet.2024.102074
      PMID: 39612941
    • Journal Article
      The evolution of steatosis and fibrosis in mice on a MASH-inducing diet and the effects of housing temperature
      Blok NB, Myronovych A, McMahon G, Bozadjieva-Kramer N, Seeley RJ. American Journal of Physiology - Endocrinology and Metabolism, 2025 Apr 1; 328 (4): E513 - E523. DOI:10.1152/ajpendo.00401.2024
      PMID: 39998384
    • Journal Article
      Intraduodenal administration of Reg3g improves gut barrier function and mitigates hepatic steatosis in mice
      Shin JH, Bozadjieva-Kramer N, Shao Y, Mercer AJ, Lyons-Abbott S, Awan RR, Lewis A, Seeley RJ. American Journal of Physiology - Endocrinology and Metabolism, 2025 Mar 1; 328 (3): E447 - E456. DOI:10.1152/ajpendo.00132.2024
      PMID: 39970263
    • Journal Article
      Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP
      Wang Y, Qiu W, Kernodle S, Parker C, Padilla MA, Su J, Tomlinson AJ, Oldham S, Field J, Bernard E, Hornigold D, Rhodes CJ, Olson DP, Seeley RJ, Myers MG. Molecular Metabolism, 2025 Feb 1; 92: DOI:10.1016/j.molmet.2024.102093
      PMID: 39755369
    • Preprint
      A single dorsal vagal complex circuit mediates the aversive and anorectic responses to GLP1R agonists.
      Yacawych WT, Wang Y, Zhou G, Hassan S, Kernodle S, Sass F, DeVaux M, Wu I, Rupp A, Tomlinson AJ, Lin Z, Secher A, Raun K, Pers T, Seeley RJ, Myers M, Qiu W. 2025 Jan 24; DOI:10.1101/2025.01.21.634167
      PMID: 39896596
    • Journal Article
      GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
      Hes C, Gui LT, Bay A, Alvarez F, Katz P, Paul T, Bozadjieva-Kramer N, Seeley RJ, Piccirillo CA, Sabatini PV. Molecular Metabolism, 2025 Jan 1; 91: DOI:10.1016/j.molmet.2024.102070
      PMID: 39608751
    Featured News & Stories 2025 Dean's Lecture and Bold Science Symposium
    Medical School News
    2025 Dean’s Lecturer: GLP-1 therapies saving, improving lives of many patients
    Lives are being saved, and many others are being changed dramatically, by current GLP-1 therapies like tirzepatide, which has helped many patients treat type 2 diabetes and sleep apnea, and also lose weight. It has been a long road from bench research to clinical trials to the health care market, but patients are now benefitting more than ever, according to a leading scientist who served as the keynote speaker for the second annual Dean’s Lecture and Bold Science Symposium, “Metabolism Research from Bench to Bedside.” Daniel Skovronsky, M.D., Ph.D., chief scientific officer and executive vice president of science and technology at Eli Lilly and Company and president of Research Laboratories and Lilly Immunology, was the Dean’s Lecturer on April 14 at the North Campus Research Complex Dining Hall.
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    Health Lab
    Randy Seeley gets a lot of questions about GLP-1s. Here’s why
    A Michigan Medicine Ph.D. researcher dissected bariatric surgery to understand how it actually works, contributing to obesity therapies that have given rise to drugs like Ozempic and Wegovy.
    Smiling tall white man in glasses and a dark blue suit.
    Department News
    Randy Seeley gets a lot of questions about GLP-1s. Here’s why.
    Learn more about Randy Seeley, PhD, and why his research has so many people turning to him for answers about weight-loss drugs.
    Illustrated graphic of a person working in a lab
    Department News
    Why does bariatric surgery work? A peptide holds one more clue
    A recent paper published in Cell Metabolism described one more key to understand how the surgery works: The triggering of an increase of an antimicrobial peptide called Regenerating Islet-Derived Protein 3 Gamma (Reg3g).