Randy J Seeley
Henry King Ransom Professor of Surgery
Professor of Surgery
Professor of Internal Medicine
Professor of Nutritional Sciences
Surgery
2800 Plymouth Rd
Ann Arbor, MI 48109
[email protected]

Available to mentor

Randy J Seeley
Professor
  • About
  • Links
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Randy Seeley is the Henry King Ransom Endowed Professor of Surgery, Internal Medicine, and Nutritional Sciences at the University of Michigan School of Medicine. He also serves as the director of the NIH-funded Michigan Nutrition Obesity Research Center (MNORC). Before that, Dr. Seeley was Professor of Medicine and held the Donald C. Harrison Endowed Chair at the University of Cincinnati College of Medicine. He also served as the Director of the Cincinnati Diabetes and Obesity Center (CDOC). His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Dr. Seeley received his B.A. from Grinnell College in 1989 and his Ph.D. from the University of Pennsylvania in 1993. He then spent two years as a fellow and two years on the faculty at the University of Washington before relocating to the University of Cincinnati in 1997 and then to the University of Michigan in 2014. He has published over 390 peer-reviewed articles including articles in Science, Nature, Nature Medicine, Nature Neuroscience, Science Translational Medicine, Cell Metabolism, The Journal of Clinical Investigation, and the New England Journal of Medicine. Collectively, this work has been cited more than 43,000 times and Dr. Seeley has a Scopus h-index of 103. He is the recipient of the 2003 Lilly Scientific Achievement Award from the Obesity Society given to the individual with the highest level of scientific achievement in obesity research in North America less than 15 years after their terminal degree. He is also the co-recipient of the 2008 Ernst Oppenheimer Award from the Endocrine Society. This Award is the premier award to an investigator under the age of 45 in recognition of meritorious accomplishment in the field of basic or clinical endocrinology. He also received the 2009 Outstanding Scientific Achievement Award from the American Diabetes Association. This award is presented to an individual medical researcher under age 45 who has made an outstanding contribution to diabetes research that demonstrates both originality and independence of thought.

    Dr. Seeley has also served on numerous review panels for the NIH and was Chair of the Integrative Physiology of Obesity and Diabetes review panel. He served on the NIDDK Clinical Obesity Research Panel and on the Board of Reviewing Editors for Science. He currently serves as Senior Associate Editor for Diabetes.

    Dr. Seeley has also been sought after by companies trying to bring new therapies for obesity and diabetes to patients. He has served as a consultant or member of a Scientific Advisory Board for venture capital, medical device, pharmaceutical, and biotech companies such as Procter & Gamble, Johnson & Johnson, Novartis, Novo Nordisk, Eli Lilly, Merck, Takeda, Amylin, Angiochem, Zealand, Boehringer Ingelheim, Eisai, Janssen, Novartis, Sanofi, Kallyope, Scohia, Ironwood Pharmaceuticals, Zafgen, Gilead, Kintai, Ionis, Rewind Health, and Calibrate. His laboratory has worked on numerous collaborative research projects with industry partners including Ethicon Endo-Surgery, Procter & Gamble, Pfizer, Novo Nordisk, Amylin, Roche, Merck, Zafgen, Zealand, Mannkind, Boehringer Ingelheim, Easai, Givaudan, AstraZeneca, Ablaris, Kintai, Energesis, Ionis, Fractyl, Amgen, Glyscend, Bullfrog AI and Eli Lilly. He has also been sought for numerous media interviews about obesity therapy including in the New York Times, Wall Street Journal, STAT News, and PBS’s Nova.

    Links
    Qualifications
    • NRSA Post-Doctoral Fellowship
      University of Washington, Psychology, 1997
    • Ph.D.
      University of Pennsylvania, Philadelphia, 2018
    • BA
      Grinnell College, Grinnell, 1989
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    His scientific work has focused on the brain-gut axis and its role in the regulation of energy balance and metabolism with a focus on new treatment strategies. He and his lab have worked to understand the actions of GLP-1 agonists and identify the molecular underpinnings of the potent effects of bariatric surgery on weight and metabolism.

    Recent Publications See All Publications
    • Journal Article
      NK2R control of energy expenditure and feeding to treat metabolic diseases.
      Sass F, Ma T, Ekberg JH, Kirigiti M, Ureña MG, Dollet L, Brown JM, Basse AL, Yacawych WT, Burm HB, Andersen MK, Nielsen TS, Tomlinson AJ, Dmytiyeva O, Christensen DP, Bader L, Vo CT, Wang Y, Rausch DM, Kristensen CK, Gestal-Mato M, In Het Panhuis W, Sjøberg KA, Kernodle S, Petersen JE, Pavlovskyi A, Sandhu M, Moltke I, Jørgensen ME, Albrechtsen A, Grarup N, Babu MM, Rensen PCN, Kooijman S, Seeley RJ, Worthmann A, Heeren J, Pers TH, Hansen T, Gustafsson MBF, Tang-Christensen M, Kilpeläinen TO, Myers MG, Kievit P, Schwartz TW, Hansen JB, Gerhart-Hines Z. Nature, 2024 Nov; 635 (8040): 987 - 1000. DOI:10.1038/s41586-024-08207-0
      PMID: 39537932
    • Preprint
      GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
      Hes C, Gui L, Bay A, Alvarez F, Katz P, Paul T, Bozadjieva-Kramer N, Seeley RJ, Piccirillo CA, Sabatini P. bioRxiv, DOI:10.1101/2024.09.19.613956
    • Journal Article
      Gut-muscle communication links FGF19 levels to the loss of lean muscle mass following rapid weight loss.
      Wean J, Baranwal S, Miller N, Shin JH, O'Rourke RW, Burant CF, Seeley RJ, Rothberg AE, Bozadjieva-Kramer N. Diabetes Metab, 2024 Sep; 50 (5): 101570 DOI:10.1016/j.diabet.2024.101570
      PMID: 39134173
    • Journal Article
      Liraglutide Impacts Iron Homeostasis in a Murine Model of Hereditary Hemochromatosis.
      Bozadjieva-Kramer N, Shin JH, Blok NB, Jain C, Das NK, Polex-Wolf J, Knudsen LB, Shah YM, Seeley RJ. Endocrinology, 2024 Jul 26; 165 (9): DOI:10.1210/endocr/bqae090
      PMID: 39045670
    • Journal Article
      Brown Adipose Tissue-Derived GDF15 Mediates Energy Homeostasis in a Sex-Dependent Manner
      Jena J, Garcia-Pena L-M, Sood A, Weatherford E, Peterson J, Roitershtein S, Patel P, Seeley RJ, Pereira R. Physiology, 2024 May; 39 (S1): 2018 DOI:10.1152/physiol.2024.39.s1.2018
    • Journal Article
      Sa1565 THE IMPACT OF INTESTINAL FIBROBLAST GROWTH FACTOR 15 DELETION ON REGENERATION OF FATTY LIVER AFTER 70% PARTIAL HEPATECTOMY IN DIET-INDUCED OBESE MICE
      Myronovych A, Blok N, Lewis AG, Bozadjieva-Kramer N, Seeley R. Gastroenterology, 2024 May; 166 (5): s - 477. DOI:10.1016/s0016-5085(24)01568-3
    • Journal Article
      Central glucagon-like peptide 1 receptor activation inhibits Toll-like receptor agonist-induced inflammation.
      Wong CK, McLean BA, Baggio LL, Koehler JA, Hammoud R, Rittig N, Yabut JM, Seeley RJ, Brown TJ, Drucker DJ. Cell Metab, 2024 Jan 2; 36 (1): 130 - 143.e5. DOI:10.1016/j.cmet.2023.11.009
      PMID: 38113888
    • Journal Article
      Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.
      Bozadjieva-Kramer N, Shin JH, Li Z, Rupp AC, Miller N, Kernodle S, Lanthier N, Henry P, Seshadri N, Myronovych A, MacDougald OA, O'Rourke RW, Kohli R, Burant CF, Rothberg AE, Seeley RJ. JCI Insight, 2024 Apr 8; 9 (7): DOI:10.1172/jci.insight.174164
      PMID: 38587078
    Featured News & Stories Illustrated graphic of a person working in a lab
    Department News
    Why does bariatric surgery work? A peptide holds one more clue
    A recent paper published in Cell Metabolism described one more key to understand how the surgery works: The triggering of an increase of an antimicrobial peptide called Regenerating Islet-Derived Protein 3 Gamma (Reg3g).