Associate Professor of Molecular and Integrative Physiology
Associate Professor of Internal Medicine and Associate Director Academic Program, Molecular and Integrative Physiology
Ann Arbor
MI
48109,
[email protected]
MI
48109,
Available to mentor
Scott F Leiser
Associate Professor
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Postdoctoral Research FellowUniversity of Washington, Seattle, WA, 2015
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberCenter for Cell Plasticity and Organ Design
Research in the Leiser lab is focused on the molecular mechanisms of aging, specifically how stress and metabolism affect the aging process. They utilize a translational, multi-system approach, including the nematode Caenorhabditis elegans, multiple mammalian in vitro tissue culture models, and mouse models, toward achieving a long-term goal of developing treatments to prevent age-related diseases and both improve and extend human lifespan. With this model in mind, they study how environmental perception, metabolism and the flavin-containing monooxygenase gene family each regulate healthspan and longevity.
Leiser Lab
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Choi HS, Bhat A, Howington MB, Schaller ML, Cox RL, Huang S, Beydoun S, Miller HA, Tuckowski AM, Mecano J, Dean ES, Jensen L, Beard DA, Evans CR, Leiser SF. Nat Commun, 2023 Feb 2; 14 (1): 562Journal ArticleFMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans.
DOI:10.1038/s41467-023-36181-0 PMID: 36732543 -
Miller HA, Huang S, Dean ES, Schaller ML, Tuckowski AM, Munneke AS, Beydoun S, Pletcher SD, Leiser SF. Nat Commun, 2022 Jun 7; 13 (1): 3271Journal ArticleSerotonin and dopamine modulate aging in response to food odor and availability.
DOI:10.1038/s41467-022-30869-5 PMID: 35672307 -
Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF. Commun Biol, 2021 Feb 26; 4 (1): 258Journal ArticleAn alternative food source for metabolism and longevity studies in Caenorhabditis elegans.
DOI:10.1038/s42003-021-01764-4 PMID: 33637830 -
Huang S, Howington MB, Dobry CJ, Evans CR, Leiser SF. Front Cell Dev Biol, 2021 9: 630188Journal ArticleFlavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism.
DOI:10.3389/fcell.2021.630188 PMID: 33644069 -
Miller HA, Dean ES, Pletcher SD, Leiser SF. Elife, 2020 Dec 10; 9:Journal ArticleCell non-autonomous regulation of health and longevity.
DOI:10.7554/eLife.62659 PMID: 33300870 -
Rossner R, Kaeberlein M, Leiser SF. J Biol Chem, 2017 Jul 7; 292 (27): 11138 - 11146.Journal ArticleFlavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.
DOI:10.1074/jbc.R117.779678 PMID: 28515321 -
Miller H, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Aging Cell, 2017 Dec; 16 (6): 1425 - 1429.Journal ArticleGenetic interaction with temperature is an important determinant of nematode longevity.
DOI:10.1111/acel.12658 PMID: 28940623 -
Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M. Science, 2015 Dec 11; 350 (6266): 1375 - 1378.Journal ArticleCell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
DOI:10.1126/science.aac9257 PMID: 26586189
