Scott F Leiser
Associate Professor of Molecular and Integrative Physiology
Associate Professor of Internal Medicine and Associate Director Academic Program, Molecular and Integrative Physiology
Ann Arbor
MI
48109,
[email protected]

Available to mentor

Scott F Leiser
Associate Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Links
  • Recent Publications
  • Qualifications
    • Postdoctoral Research Fellow
      University of Washington, Seattle, WA, 2015
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    Research Overview

    Research in the Leiser lab is focused on the molecular mechanisms of aging, specifically how stress and metabolism affect the aging process. They utilize a translational, multi-system approach, including the nematode Caenorhabditis elegans, multiple mammalian in vitro tissue culture models, and mouse models, toward achieving a long-term goal of developing treatments to prevent age-related diseases and both improve and extend human lifespan. With this model in mind, they study how environmental perception, metabolism and the flavin-containing monooxygenase gene family each regulate healthspan and longevity.

    Links
    • Leiser Lab
    Recent Publications See All Publications
    • Journal Article
      FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans.
      Choi HS, Bhat A, Howington MB, Schaller ML, Cox RL, Huang S, Beydoun S, Miller HA, Tuckowski AM, Mecano J, Dean ES, Jensen L, Beard DA, Evans CR, Leiser SF. Nat Commun, 2023 Feb 2; 14 (1): 562 DOI:10.1038/s41467-023-36181-0
      PMID: 36732543
    • Journal Article
      Serotonin and dopamine modulate aging in response to food odor and availability.
      Miller HA, Huang S, Dean ES, Schaller ML, Tuckowski AM, Munneke AS, Beydoun S, Pletcher SD, Leiser SF. Nat Commun, 2022 Jun 7; 13 (1): 3271 DOI:10.1038/s41467-022-30869-5
      PMID: 35672307
    • Journal Article
      An alternative food source for metabolism and longevity studies in Caenorhabditis elegans.
      Beydoun S, Choi HS, Dela-Cruz G, Kruempel J, Huang S, Bazopoulou D, Miller HA, Schaller ML, Evans CR, Leiser SF. Commun Biol, 2021 Feb 26; 4 (1): 258 DOI:10.1038/s42003-021-01764-4
      PMID: 33637830
    • Journal Article
      Flavin-Containing Monooxygenases Are Conserved Regulators of Stress Resistance and Metabolism.
      Huang S, Howington MB, Dobry CJ, Evans CR, Leiser SF. Front Cell Dev Biol, 2021 9: 630188 DOI:10.3389/fcell.2021.630188
      PMID: 33644069
    • Journal Article
      Cell non-autonomous regulation of health and longevity.
      Miller HA, Dean ES, Pletcher SD, Leiser SF. Elife, 2020 Dec 10; 9: DOI:10.7554/eLife.62659
      PMID: 33300870
    • Journal Article
      Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes.
      Rossner R, Kaeberlein M, Leiser SF. J Biol Chem, 2017 Jul 7; 292 (27): 11138 - 11146. DOI:10.1074/jbc.R117.779678
      PMID: 28515321
    • Journal Article
      Genetic interaction with temperature is an important determinant of nematode longevity.
      Miller H, Fletcher M, Primitivo M, Leonard A, Sutphin GL, Rintala N, Kaeberlein M, Leiser SF. Aging Cell, 2017 Dec; 16 (6): 1425 - 1429. DOI:10.1111/acel.12658
      PMID: 28940623
    • Journal Article
      Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
      Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M. Science, 2015 Dec 11; 350 (6266): 1375 - 1378. DOI:10.1126/science.aac9257
      PMID: 26586189