Stephen J Weiss
E Gifford and Love Barnett Upjohn Professor of Internal Medicine and Oncology
Professor of Internal Medicine
Medical School and Research Professor
Life Sciences Institute
Life Sciences Institute
210 Washtenaw
Ann Arbor, Mi 48109
[email protected]

Available to mentor
Stephen J Weiss
Research Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
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    About

    I hold the Upjohn Chair in Medicine & Oncology at the University. I am a member of the Life Sciences Institute and have previously served as the Chief of Molecular Medicine in the Dept of Int Med, the interim Director of the Life Sciences Institute and the Assoc Director of Basic Science Research at the Rogel Cancer Center. I have no clinical or formal teaching responsibilities and confine all of my efforts to the my research program.

    Qualifications
    • Fellow
      University of Michigan, Internal Medicine, 1980
    • Intern/Resident
      Washington University in St. Louis School of Medicine, Pathology, 1978
    • MD
      Ohio State University, 1977
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Rogel Cancer Center
    Research Overview

    Research interests focus on interactions between mesenchymal/skeletal stems as well as adipocytes and the surrounding extracellular matrix both in vitro and in vivo with particular emphasis on the role of mechanotransduction-linked pathways impacting nuclear transcription.

    Recent Publications See All Publications
    • Journal Article
      Genetic and pharmacological targeting of Snail inhibits atherosclerosis by relieving intraplaque endothelium dysfunction and associated inflammation
      Ren BX, Zeng ZL, Deng L, Hu JM, Chen MZ, Jiang HW, Zang CZ, Fang ST, Weiss SJ, Liu J, Fu R, Wu ZQ. Acta Pharmacologica Sinica, 2025 Jan 1; DOI:10.1038/s41401-025-01519-5
    • Journal Article
      An In Vitro Model of Murine Osteoclast-Mediated Bone Resorption
      Sun X, Wang Z, Tang Y, Weiss SJ, Zhu L. Bio-protocol, 2024 Nov 5; 14 (21): DOI:10.21769/BioProtoc.5100
    • Journal Article
      Mmp14-dependent remodeling of the pericellular–dermal collagen interface governs fibroblast survival
      Sabeh F, Li XY, Olson AW, Botvinick E, Kurup A, Gimenez LE, Cho JS, Weiss SJ. Journal of Cell Biology, 2024 Sep 2; 223 (9): DOI:10.1083/jcb.202312091
      PMID: 38990714
    • Journal Article
      Stromal Cell-SLIT3/Cardiomyocyte-ROBO1 Axis Regulates Pressure Overload-Induced Cardiac Hypertrophy
      Liu X, Li B, Wang S, Zhang E, Schultz M, Touma M, Da Rocha AM, Evans SM, Eichmann A, Herron T, Chen R, Xiong D, Jaworski A, Weiss S, Si MS. Circulation Research, 2024 Mar 29; 134 (7): 913 - 930. DOI:10.1161/CIRCRESAHA.122.321292
      PMID: 38414132
    • Journal Article
      The checkpoint inhibitor PD-1H/VISTA controls osteoclast-mediated multiple myeloma bone disease
      Fu J, Li S, Ma H, Yang J, Pagnotti GM, Brown LM, Weiss SJ, Mapara MY, Lentzsch S. Nature Communications, 2023 Dec 1; 14 (1): DOI:10.1038/s41467-023-39769-8
      PMID: 37460553
    • Journal Article
      11. Mesenchymal Lineage Discoidin Domain Receptor 2 Affects Heterotopic Ossification Formation and Extracellular Matrix Organization
      Pagani CA, Bancroft AC, Tower RJ, Livingston N, Sun Y, Hong JY, Nanes BA, Kent RN, Dean K, Franceschi R, Baker BM, Weiss SJ, Levi B. Plastic & Reconstructive Surgery Global Open, 2023 May 18; 11 (5S): 7 - 8. DOI:10.1097/01.gox.0000937640.56138.fb
      PMID: PMC10194745
    • Journal Article
      A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling
      Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Feng W, Sun X, Hespe GE, Wang Z, Stemmler MP, Brabletz S, Brabletz T, Keller ET, Ma J, Cho JS, Yang J, Weiss SJ. EMBO Journal, 2023 Apr 3; 42 (7): DOI:10.15252/embj.2022111148
      PMID: 36843552
    • Journal Article
      Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption
      Zhu L, Tang Y, Li XY, Kerk SA, Lyssiotis CA, Sun X, Wang Z, Cho JS, Ma J, Weiss SJ. Journal of Cell Biology, 2023 Apr 3; 222 (4): DOI:10.1083/jcb.202206121
      PMID: 36880731