Leslie Satin
Research Professor of Pharmacology
Professor of Pharmacology
Professor of Internal Medicine
Brehm Tower 5128, Kellogg Eye Center, 1000 Wall St.
Ann Arbor, MI 48105
[email protected]

Available to mentor

Leslie Satin
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Dr. Les Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology and also an investigator in the Brehm Diabetes Research Center and the Caswell Diabetes Institute. He is an affiliate professor of MEND, in Internal Medicine. He trained at UCLA, SUNY Stony Brook, and the University of Washington, Seattle, where he was in the Department of Physiology and Biophysics of the UW Medical School and a fellow in Metabolism and Endocrinology at the Seattle Veterans Affairs Medical Center. Dr. Satin was trained in the areas of membrane biophysics, neurobiology, electrophysiology and ion channels. He has been on the faculty at UM since 2008. In 2016, Dr. Satin was visiting professor at the University of Uppsala in Uppsala, Sweden with Drs. Anders Tengholm and Sebastian Barg in the Department of Medical Cell Biology.

    • fellow
      University of Washington, Seattle, Physiology and Biophysics, 1990
    • postdoctoral fellow
      SUNY Stont Brook, Neurobiology and Behavior, 1984
    • Ph.D.
      University of California at Los Angeles, Los Angeles, 1982
    Center Memberships
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Center for Integrative Research in Critical Care
    Research Overview

    Pancreatic islets, beta cell stimulus secretion coupling, beta cell biology, oscillations in biological systems, calcium signaling in organelles and cytosol, mathematical modeling, genetically encoded sensors, live cell imaging.

    Recent Publications See All Publications
    • Journal Article
      Proinsulin folding and trafficking defects trigger a common pathological disturbance of endoplasmic reticulum homeostasis.
      Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour SA, Satin LS, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman RJ, Liu M, Arvan P. Protein Sci, 2024 Apr; 33 (4): e4949 DOI:10.1002/pro.4949
      PMID: 38511500
    • Journal Article
      KATP channel activity and slow oscillations in pancreatic beta cells are regulated by mitochondrial ATP production.
      Corradi J, Thompson B, Fletcher PA, Bertram R, Sherman AS, Satin LS. J Physiol, 2023 Dec; 601 (24): 5655 - 5667. DOI:10.1113/JP284982
      PMID: 37983196
    • Journal Article
      Deconstructing the integrated oscillator model for pancreatic β-cells.
      Bertram R, Marinelli I, Fletcher PA, Satin LS, Sherman AS. Math Biosci, 2023 Oct 4; 365: 109085 DOI:10.1016/j.mbs.2023.109085
      PMID: 37802364
    • Journal Article
      Sex Differences in Pancreatic β-Cell Physiology and Glucose Homeostasis in C57BL/6J Mice.
      Jo S, Beetch M, Gustafson E, Wong A, Oribamise E, Chung G, Vadrevu S, Satin LS, Bernal-Mizrachi E, Alejandro EU. J Endocr Soc, 2023 Aug 2; 7 (9): bvad099 DOI:10.1210/jendso/bvad099
      PMID: 37873500
    • Journal Article
      ER stress increases expression of intracellular calcium channel RyR1 to modify Ca2+ homeostasis in pancreatic beta cells.
      Zhang IX, Herrmann A, Leon J, Jeyarajan S, Arunagiri A, Arvan P, Gilon P, Satin LS. J Biol Chem, 2023 Aug; 299 (8): 105065 DOI:10.1016/j.jbc.2023.105065
      PMID: 37468098
    • Journal Article
      Ca2+ release or Ca2+ entry, that is the question: what governs Ca2+ oscillations in pancreatic β cells?
      Fletcher PA, Thompson B, Liu C, Bertram R, Satin LS, Sherman AS. Am J Physiol Endocrinol Metab, 2023 Jun 1; 324 (6): E477 - E487. DOI:10.1152/ajpendo.00030.2023
      PMID: 37074988
    • Chapter
      Satin L. Calcium Signals, 1-1-1-3 DOI:10.1088/978-0-7503-2009-2ch1
    • Journal Article
      Simultaneous Measurement of Changes in Mitochondrial and Endoplasmic Reticulum Free Calcium in Pancreatic Beta Cells.
      Jeyarajan S, Zhang IX, Arvan P, Lentz SI, Satin LS. Biosensors (Basel), 2023 Mar 14; 13 (3): DOI:10.3390/bios13030382
      PMID: 36979594
    Featured News & Stories
    Department News
    Dr. Les Satin has book published for IOP Press
    Dr. Les Satin has book published for IOP Press
    Department News
    Les Satin interviewed in March 2023 Biophysical Society Bulletin
    Les Satin, University of Michigan Medical School professor, was interviewed in March 2023 Biophysical Society Bulletin.