
Brehm Tower 5128, Kellogg Eye Center, 1000 Wall St.
Ann Arbor, MI 48105
Available to mentor

Dr. Les Satin is the Joanne I. Moore Endowed Research Professor of Pharmacology and also an investigator in the Brehm Diabetes Research Center and the Caswell Diabetes Institute. He is an affiliate professor of MEND, in Internal Medicine. He trained at UCLA, SUNY Stony Brook, and the University of Washington, Seattle, where he was in the Department of Physiology and Biophysics of the UW Medical School and a fellow in Metabolism and Endocrinology at the Seattle Veterans Affairs Medical Center. Dr. Satin was trained in the areas of membrane biophysics, neurobiology, electrophysiology and ion channels. He has been on the faculty at UM since 2008. In 2016, Dr. Satin was visiting professor at the University of Uppsala in Uppsala, Sweden with Drs. Anders Tengholm and Sebastian Barg in the Department of Medical Cell Biology.
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fellowUniversity of Washington, Seattle, Physiology and Biophysics, 1990
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postdoctoral fellowSUNY Stony Brook, Neurobiology and Behavior, 1984
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Center MemberCaswell Diabetes Institute
Pancreatic islets, beta cell stimulus secretion coupling, beta cell biology, oscillations in biological systems, calcium signaling in organelles and cytosol, mathematical modeling, genetically encoded sensors, live cell imaging.
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Wang Z, Gurlo T, Satin LS, Fraser SE, Butler PC. Cells, 2025 Feb 1; 14 (3):Journal ArticleSubcellular Compartmentalization of Glucose Mediated Insulin Secretion
DOI:10.3390/cells14030198 PMID: 39936989 -
Liu C, Fletcher PA, Marinelli I, Bertram R, Satin LS, Sherman AS. 2024 Jul 27;Proceeding / Abstract / PosterThe Mechanisms of Pulsatile Basal Insulin Secretion
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Liu C, Fletcher PA, Marinelli I, Bertram R, Satin LS, Sherman AS. 2024 Jul 27;Proceeding / Abstract / PosterThe Mechanisms of Pulsatile Basal Insulin Secretion
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Satin LS, Corradi J, Sherman AS. Diabetes, 2024 Jun 1; 73 (6): 844 - 848.Journal ArticleDo We Need a New Hypothesis for K<inf>ATP</inf> Closure in b-Cells? Distinguishing the Baby From the Bathwater
DOI:10.2337/db24-0131 PMID: 38640066 -
Arunagiri A, Alam M, Haataja L, Draz H, Alasad B, Samy P, Sadique N, Tong Y, Cai Y, Shakeri H, Fantuzzi F, Ibrahim H, Jang I, Sidarala V, Soleimanpour S, Satin L, Otonkoski T, Cnop M, Itkin-Ansari P, Kaufman R, Liu M, Arvan P. Protein Science, 2024 Mar 3; 33 (4):Journal ArticleProinsulin Folding and Trafficking Defects Trigger a Common Pathological Disturbance of Endoplasmic Reticulum Homeostasis
DOI:10.1002/pro.4949 -
Satin LS. 2025 Apr 28;PresentationOscillatory Metabolism and Insulin Secretion
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Corradi J, Satin LS. 2024 Apr 26;Proceeding / Abstract / PosterAmino acids modulate beta cell KATP activity via the PEP cycle and OXPHOS
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Corradi J, Satin LS. 2024 Apr 26;Proceeding / Abstract / PosterAmino acids modulate beta cell KATP activity via the PEP cycle and OXPHOS