Edward F Domino Research Professor of Pharmacology
Professor of Pharmacology
Professor of Medicinal Chemistry
College of Pharmacy
[email protected]
Available to mentor
John R Traynor
Professor
-
Center MemberEisenberg Family Depression Center
Edward F. Domino Research Center Traynor Lab
-
Anand JP, Moore SC, Dixon EE, Perrien Naccarato CM, West JL, Delong LJ, Burgess E, Twarozynski JJ, Traynor JR. ACS Chem Neurosci, 2024 Aug 7; 15 (15): 2830 - 2841.Journal ArticleStructure-Activity Relationships of the Fentanyl Scaffold: Identification of Antagonists as Potential Opioid Overdose Reversal Agents.
DOI:10.1021/acschemneuro.4c00203 PMID: 38994846 -
Chan WKB, Carlson HA, Traynor JR. Mol Pharmacol, 2023 May; 103 (5): 274 - 285.Journal ArticleApplication of Mixed-Solvent Molecular Dynamics Simulations for Prediction of Allosteric Sites on G Protein-Coupled Receptors.
DOI:10.1124/molpharm.122.000612 PMID: 36868791 -
Traynor JR, Moron JA. Br J Pharmacol, 2023 Apr; 180 (7): 793 - 796.Journal ArticleOpioid research in the time of the opioid crisis.
DOI:10.1111/bph.16043 PMID: 36813266 -
Olson KM, Hillhouse TM, Burgess GE, West JL, Hallahan JE, Dripps IJ, Ladetto AG, Rice KC, Jutkiewicz EM, Traynor JR. J Pharmacol Exp Ther, 2023 Mar; 384 (3): 343 - 352.Journal ArticleDelta Opioid Receptor-Mediated Antidepressant-Like Effects of Diprenorphine in Mice.
DOI:10.1124/jpet.122.001182 PMID: 36456196 -
Morales A, Mohan R, Chen X, Coffman BL, Bendahmane M, Watch L, West JL, Bakshi S, Traynor JR, Giovannucci DR, Kammermeier PJ, Axelrod D, Currie KPM, Smrcka AV, Anantharam A. J Gen Physiol, 2023 Feb 6; 155 (2):Journal ArticlePACAP and acetylcholine cause distinct Ca2+ signals and secretory responses in chromaffin cells.
DOI:10.1085/jgp.202213180 PMID: 36538657 -
Olson KM, Devereaux AL, Chatterjee P, Saldaña-Shumaker SL, Shafer A, Plotkin A, Kandasamy R, MacKerell AD, Traynor JR, Cunningham CW. Front Pharmacol, 2023 14: 1230053Journal ArticleNitro-benzylideneoxymorphone, a bifunctional mu and delta opioid receptor ligand with high mu opioid receptor efficacy.
DOI:10.3389/fphar.2023.1230053 PMID: 37469877 -
Disney A, Olson KM, Shafer AM, Moore SC, Anand JP, Traynor JR, Husbands SM. ACS Chem Neurosci, 2022 Nov 2; 13 (21): 3108 - 3117.Journal ArticleOpioid Antagonists from the Orvinol Series as Potential Reversal Agents for Opioid Overdose.
DOI:10.1021/acschemneuro.2c00464 PMID: 36223082 -
Olson KM, Campbell A, Alt A, Traynor JR. ACS Pharmacol Transl Sci, 2022 Sep 9; 5 (9): 694 - 709.Journal ArticleFinding the Perfect Fit: Conformational Biosensors to Determine the Efficacy of GPCR Ligands.
DOI:10.1021/acsptsci.1c00256 PMID: 36110374
Health Lab
University of Michigan researchers may have found that the solution to prevent people from dying from a fentanyl overdose may be found within fentanyl's own chemistry.
Department News
Dr. John Traynor is one of 17 University of Michigan faculty members named 2022 AAAS Fellows.
