1000 Wall Street
Ann Arbor, MI 48105
Available to mentor
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Postgraduate FellowshipMassachusetts Institute of Technology, Chemistry, 1989
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Teaching CertificateWestern Michigan University, Education, 1976
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PhDMichigan State University, East Lansing, 1984
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BSWestern Michigan University, Kalamazoo, 1974
• Studies of the molecular mechanisms underlying inherited forms of retinal degeneration causing vision loss and blindness in affected individuals.
• Identification of disease genes associated with early and severe forms of retinal degeneration, focusing on genes expressed in the retina and retinal pigment epithelium, and necessary for the function of the light-absorbing rod and cone photoreceptor cells.
• Analysis of the cellular functions and pathogenic mechanisms associated with retinal degeneration genes using assays of protein function and enzyme activity, and mouse and rat models of human disease.
• Studies of the impact of disease-associated mutations that disrupt vitamin A metabolism needed for the synthesis and processing of the light-absorbing chromophore 11-cis retinal.
• Efforts to advance therapeutic intervention in inherited retinal diseases using small molecules and gene-replacement strategies targeting photoreceptor cells and the retinal pigment epithelium.
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Raeker MÖ, Perera ND, Karoukis AJ, Chen L, Feathers KL, Ali RR, Thompson DA, Fahim AT. Cells, 2024 Jun 19; 13 (12):Journal ArticleReduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia.
DOI:10.3390/cells13121068 PMID: 38920696 -
2024 Jan;PresentationMonaciano Symposium-III: Perspectives and Practice, Thompson D, via dei Barbieri, 01/2024, Rome, Italy
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Liton PB, Boesze-Battaglia K, Boulton ME, Boya P, Ferguson TA, Ganley IG, Kauppinnen A, Laurie GW, Mizushima N, Morishita H, Russo R, Sadda J, Shyam R, Sinha D, Thompson DA, Zacks DN. Autophagy Rep, 2023 2 (1):Journal ArticleAUTOPHAGY IN THE EYE: FROM PHYSIOLOGY TO PATHOPHYSOLOGY.
DOI:10.1080/27694127.2023.2178996 PMID: 37034386 -
Feathers KL, Jia L, Khan NW, Smith AJ, Ma J-X, Ali RR, Thompson DA. Hum Gene Ther, 2023 Jul; 34 (13-14): 639 - 648.Journal ArticleGene Supplementation in Mice Heterozygous for the D477G RPE65 Variant Implicated in Autosomal Dominant Retinitis Pigmentosa.
DOI:10.1089/hum.2022.240 PMID: 37014074 -
Chen L, Perera ND, Karoukis AJ, Feathers KL, Ali RR, Thompson DA, Fahim AT. Sci Rep, 2022 Jul 26; 12 (1): 12694Journal ArticleOxidative stress differentially impacts apical and basolateral secretion of angiogenic factors from human iPSC-derived retinal pigment epithelium cells.
DOI:10.1038/s41598-022-16701-6 PMID: 35882889 -
Zhang Q, Presswalla F, Ali RR, Zacks DN, Thompson DA, Miller JML. Aging (Albany NY), 2021 Apr 19; 13 (8): 10866 - 10890.Journal ArticlePharmacologic activation of autophagy without direct mTOR inhibition as a therapeutic strategy for treating dry macular degeneration.
DOI:10.18632/aging.202974 PMID: 33872219 -
Boyer NP, Thompson DA, Koutalos Y. Invest Ophthalmol Vis Sci, 2021 Feb 1; 62 (2): 1Journal ArticleRelative Contributions of All-Trans and 11-Cis Retinal to Formation of Lipofuscin and A2E Accumulating in Mouse Retinal Pigment Epithelium.
DOI:10.1167/iovs.62.2.1 PMID: 33523199 -
Thompson DA, Iannaccone A, Ali RR, Arshavsky VY, Audo I, Bainbridge JWB, Besirli CG, Birch DG, Branham KE, Cideciyan AV, Daiger SP, Dalkara D, Duncan JL, Fahim AT, Flannery JG, Gattegna R, Heckenlively JR, Heon E, Jayasundera KT, Khan NW, Klassen H, Leroy BP, Molday RS, Musch DC, Pennesi ME, Petersen-Jones SM, Pierce EA, Rao RC, Reh TA, Sahel JA, Sharon D, Sieving PA, Strettoi E, Yang P, Zacks DN, Monaciano Consortium . Transl Vis Sci Technol, 2020 Jun; 9 (7): 2Journal ArticleAdvancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.
DOI:10.1167/tvst.9.7.2 PMID: 32832209
