Katherine Gallagher, MD
Leland Ira Doan Research Professor of Vascular Surgery
Associate Chair, Department of Vascular Surgery Section
Professor of Surgery
Professor of Microbiology and Immunology
[email protected]

Available to mentor

Katherine Gallagher, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
  • Qualifications
    • Residency, General Surgery
      University of Maryland Medical Center, Baltimore, MD, United States
    • Postdoctoral Fellow, Vascular Surgery
      University of Pennsylvania Hospital, Philadelphia, PA, United States
    • Fellowship, Vascular Surgery
      Weill Cornell Medical Center, Columbia University Hospital, New York, NY, United States
    • MD
      University of Maryland School of Medicine, 655 W. Baltimore Street, 2002
    • BS
      University of Maryland, College Park, 1998
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Taubman Institute
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Dr. Gallagher has had a long-standing defined clinical and translational interest in the mechanisms underlying impaired diabetic wound healing. Her long-term goal is to uncover the basic mechanisms responsible for the coordination of immune cells in early tissue repair processes, determine impairments in Type 2 Diabetes and translate this knowledge to the bedside. It is my belief that the diabetic phenotype has systemic effects on bone marrow cells that alter innate immune cell phenotypes resulting in impaired peripheral wound healing.

    Since joining the faculty at the University of Michigan, Dr. Gallagher's research has focused on histone methylation changes in bone marrow progenitor cells and the impact on peripheral macrophage phenotypes as it relates to wound healing and inflammation. This work will provide important data on inflammatory macrophages in peripheral tissue and their contribution to chronic inflammation and may lead to novel treatment modalities. I have also trained numerous post-doctoral fellows/residents in my lab under NIH T32, F32, AAS grant, VESS grant and other funding mechanisms. I have a strong interest in training postdocs/residents in translational science.

    Recent Publications See All Publications
    • Journal Article
      Biofilm-derived oxylipin 10-HOME mediated immune response in women with breast implants.
      Bauer TM, Gallagher KA. J Clin Invest, 2024 Feb 1; 134 (3): DOI:10.1172/JCI176547
      PMID: 38299590
    • Journal Article
      Transforming the Future of Surgeon-Scientists.
      Ladner DP, Goldstein AM, Billiar TR, Cameron AM, Carpizo DR, Chu DI, Coopersmith CM, DeMatteo RP, Feng S, Gallagher KA, Gillanders WE, Lal BK, Lipshutz GS, Liu A, Maier RV, Mittendorf EA, Morris AM, Sicklick JK, Velazquez OC, Whitson BA, Wilke LG, Yoon SS, Zeiger MA, Farmer DL, Hwang ES, ASA Task Force for Research Sustainability . Ann Surg, 2024 Feb 1; 279 (2): 231 - 239. DOI:10.1097/SLA.0000000000006148
      PMID: 37916404
    • Journal Article
      Current Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.
      Gallagher KA, Mills JL, Armstrong DG, Conte MS, Kirsner RS, Minc SD, Plutzky J, Southerland KW, Tomic-Canic M, American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Lifestyle and Cardiometabolic Health . Circulation, 2024 Jan 23; 149 (4): e232 - e253. DOI:10.1161/CIR.0000000000001192
      PMID: 38095068
    • Proceeding / Abstract / Poster
      Abstract 12885: Pathological Perk/Atf4 Activation in Abdominal Aortic Aneurysm Formation
      Zhang H, Mangum KD, Joshi A, Callow B, Xing X, Tsoi LC, O'Riordan M, Gudjonsson J, Gallagher KA, Davis FM. Circulation, 2023 Nov 7; 148 (Suppl_1): a12885 - a12885. DOI:10.1161/circ.148.suppl_1.12885
    • Journal Article
      Genome-wide association meta-analysis identifies risk loci for abdominal aortic aneurysm and highlights PCSK9 as a therapeutic target.
      Roychowdhury T, Klarin D, Levin MG, Spin JM, Rhee YH, Deng A, Headley CA, Tsao NL, Gellatly C, Zuber V, Shen F, Hornsby WE, Laursen IH, Verma SS, Locke AE, Einarsson G, Thorleifsson G, Graham SE, Dikilitas O, Pattee JW, Judy RL, Pauls-Verges F, Nielsen JB, Wolford BN, Brumpton BM, Dilmé J, Peypoch O, Juscafresa LC, Edwards TL, Li D, Banasik K, Brunak S, Jacobsen RL, Garcia-Barrio MT, Zhang J, Rasmussen LM, Lee R, Handa A, Wanhainen A, Mani K, Lindholt JS, Obel LM, Strauss E, Oszkinis G, Nelson CP, Saxby KL, van Herwaarden JA, van der Laan SW, van Setten J, Camacho M, Davis FM, Wasikowski R, Tsoi LC, Gudjonsson JE, Eliason JL, Coleman DM, Henke PK, Ganesh SK, Chen YE, Guan W, Pankow JS, Pankratz N, Pedersen OB, Erikstrup C, Tang W, Hveem K, Gudbjartsson D, Gretarsdottir S, Thorsteinsdottir U, Holm H, Stefansson K, Ferreira MA, Baras A, Kullo IJ, Ritchie MD, Christensen AH, Iversen KK, Eldrup N, Sillesen H, Ostrowski SR, Bundgaard H, Ullum H, Burgess S, Gill D, Gallagher K, Sabater-Lleal M, DiscovEHR , Regeneron Genetics Center , UK Aneurysm Growth Study , DBDS Genomic Consortium , VA Million Veteran Program , Surakka I, Jones GT, Bown MJ, Tsao PS, Willer CJ, Damrauer SM. Nat Genet, 2023 Nov; 55 (11): 1831 - 1842. DOI:10.1038/s41588-023-01510-y
      PMID: 37845353
    • Journal Article
      The Histone Methyltransferase SETDB2 Modulates Tissue Inhibitors of Metalloproteinase-Matrix Metalloproteinase Activity During Abdominal Aortic Aneurysm Development.
      Davis FM, Melvin WJ, Mangum K, Tsoi LC, Joshi AD, Cai Q, Henke PK, Gudjonsson JE, Gallagher KA. Ann Surg, 2023 Sep 1; 278 (3): 426 - 440. DOI:10.1097/SLA.0000000000005963
      PMID: 37325923
    • Proceeding / Abstract / Poster
      The Histone Methyltransferase Whsc1 Regulates Tgfb-driven Macrophage to Myofibroblast Transition During Normal Wound Healing
      Mangum K, Joshi A, Erturk A, Mazumder P, Barrett E, Wolf S, Obi A, Kunkel S, Davis F, Gallagher K. Journal of Vascular Surgery, 2023 Sep; 78 (3): e19 DOI:10.1016/j.jvs.2023.06.035
    • Journal Article
      Macrophage-mediated PDGF Activation Correlates With Regenerative Outcomes Following Musculoskeletal Trauma.
      Chowdary AR, Maerz T, Henn D, Hankenson KD, Pagani CA, Marini S, Gallagher K, Aguilar CA, Tower RJ, Levi B. Ann Surg, 2023 Aug 1; 278 (2): e349 - e359. DOI:10.1097/SLA.0000000000005704
      PMID: 36111847