Available to mentor
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Residency, General SurgeryUniversity of Maryland Medical Center, Baltimore, MD, United States
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Postdoctoral Fellow, Vascular SurgeryUniversity of Pennsylvania Hospital, Philadelphia, PA, United States
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Fellowship, Vascular SurgeryWeill Cornell Medical Center, Columbia University Hospital, New York, NY, United States
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MDUniversity of Maryland School of Medicine, 655 W. Baltimore Street, 2002
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BSUniversity of Maryland, College Park, 1998
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Center MemberSamuel and Jean Frankel Cardiovascular Center
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Center MemberTaubman Institute
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Center MemberCaswell Diabetes Institute
Dr. Gallagher has had a long-standing defined clinical and translational interest in the mechanisms underlying impaired diabetic wound healing. Her long-term goal is to uncover the basic mechanisms responsible for the coordination of immune cells in early tissue repair processes, determine impairments in Type 2 Diabetes and translate this knowledge to the bedside. It is my belief that the diabetic phenotype has systemic effects on bone marrow cells that alter innate immune cell phenotypes resulting in impaired peripheral wound healing.
Since joining the faculty at the University of Michigan, Dr. Gallagher's research has focused on histone methylation changes in bone marrow progenitor cells and the impact on peripheral macrophage phenotypes as it relates to wound healing and inflammation. This work will provide important data on inflammatory macrophages in peripheral tissue and their contribution to chronic inflammation and may lead to novel treatment modalities. I have also trained numerous post-doctoral fellows/residents in my lab under NIH T32, F32, AAS grant, VESS grant and other funding mechanisms. I have a strong interest in training postdocs/residents in translational science.
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Melvin WJ, Bauer TM, Magnum KD, Audu CO, Shadiow J, Barrett E, Joshi A, Moon JY, Bogel R, Mazumder P, Wolf SJ, Kunkel S, Gudjonsson JE, Davis FM, Gallagher KA. JCI Insight, 2024 Aug 27;Journal ArticleThe histone methyltransferase mixed-lineage-leukemia-1 drives T cell phenotype via notch signaling in diabetic tissue repair.
DOI:10.1172/jci.insight.179012 PMID: 39250432 -
Wolf-Fortune S, Joshi A, Moon J, Mangum K, Bauer T, Shadiow J, Gudjonsson JE, Kahlenberg M, Gallagher K. Journal of Investigative Dermatology, 2024 Aug; 144 (8): s72Journal Article416 Epigenetic regulation of keratinocyte-mediated IFN kappa expression in IMQ-induced psoriasis
DOI:10.1016/j.jid.2024.06.432 -
Entrup GP, Unadkat A, Warheit-Niemi HI, Thomas B, Gurczynski SJ, Cui Y, Smith AM, Gallagher KA, Moore BB, Singer K. J Immunol, 2024 Aug 1; 213 (3): 317 - 327.Journal ArticleObesity Inhibits Alveolar Macrophage Responses to Pseudomonas aeruginosa Pneumonia via Upregulation of Prostaglandin E2 in Male, but Not Female, Mice.
DOI:10.4049/jimmunol.2400140 PMID: 38905107 -
Mangum KD, Li Q, Bauer TM, Wolf SJ, Shadiow J, Moon JY, Barrett EC, Joshi AD, Ahmed Z, Wasikowski R, Boyer K, Obi AT, Davis FM, Chang L, Tsoi LC, Gudjonsson J, Gallagher KA. 2024 Jul 10;PreprintEpigenetic Alteration of Smooth Muscle Cells Regulates Endothelin-Dependent Blood Pressure and Hypertensive Arterial Remodeling.
DOI:10.1101/2024.07.09.24310178 PMID: 39040193 -
Moon JY, Gallagher KA. Immunity, 2024 Jul 9; 57 (7): 1448 - 1451.Journal ArticleScavengers in islets fuel diabetic autoimmunity.
DOI:10.1016/j.immuni.2024.06.008 PMID: 38986438 -
Bauer T, Mangum KD, Barrett E, Joshi A, Buckley S, Gudjonsson J, Davis F, Obi A, Moore B, Gallagher K. Journal of Vascular Surgery, 2024 Jun; 79 (6): e214Proceeding / Abstract / PosterImpaired Epigenetic Reprogramming prevents Fibroblast to Myofibroblast Transition in Diabetic Wounds
DOI:10.1016/j.jvs.2024.03.274 -
Mangum KD, Bauer T, Joshi A, Wolf-Fortune S, Moon J, Li Q, Gudjonsson J, Obi A, Davis F, Gallagher K. Journal of Vascular Surgery, 2024 Jun; 79 (6): e292Proceeding / Abstract / PosterThe Histone Demethylase JMJD3 Regulates Smooth Muscle Cell Phenotype during Macrophage-mediated Inflammation
DOI:10.1016/j.jvs.2024.03.376 -
Callow B, Mangum KD, Bauer T, Xing X, O'Riordan M, Gudjonsson J, Obi AT, Gallagher KA, Davis FM. Arteriosclerosis Thrombosis and Vascular Biology, 2024 May; 44 (Suppl_1):Journal ArticleAbstract 1006: Pathological PERK/ATF4 Activation In Vascular Smooth Muscle Cells Drives Abdominal Aortic Aneurysm Development
DOI:10.1161/atvb.44.suppl_1.1006