Katherine Gallagher, MD
Leland Ira Doan Research Professor of Vascular Surgery
Associate Chair, Department of Vascular Surgery Section
Professor of Surgery
Professor of Microbiology and Immunology
[email protected]

Available to mentor
Katherine Gallagher, MD
Professor
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications
    • Qualifications
    • Residency, General Surgery
      University of Maryland Medical Center, Baltimore, MD, United States
    • Postdoctoral Fellow, Vascular Surgery
      University of Pennsylvania Hospital, Philadelphia, PA, United States
    • Fellowship, Vascular Surgery
      Weill Cornell Medical Center, Columbia University Hospital, New York, NY, United States
    • MD
      University of Maryland School of Medicine, 655 W. Baltimore Street, 2002
    • BS
      University of Maryland, College Park, 1998
    Center Memberships
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Caswell Diabetes Institute
    • Center Member
      Taubman Institute
    Research Overview

    Dr. Gallagher has had a long-standing defined clinical and translational interest in the mechanisms underlying impaired diabetic wound healing. Her long-term goal is to uncover the basic mechanisms responsible for the coordination of immune cells in early tissue repair processes, determine impairments in Type 2 Diabetes and translate this knowledge to the bedside. It is my belief that the diabetic phenotype has systemic effects on bone marrow cells that alter innate immune cell phenotypes resulting in impaired peripheral wound healing.

    Since joining the faculty at the University of Michigan, Dr. Gallagher's research has focused on histone methylation changes in bone marrow progenitor cells and the impact on peripheral macrophage phenotypes as it relates to wound healing and inflammation. This work will provide important data on inflammatory macrophages in peripheral tissue and their contribution to chronic inflammation and may lead to novel treatment modalities. I have also trained numerous post-doctoral fellows/residents in my lab under NIH T32, F32, AAS grant, VESS grant and other funding mechanisms. I have a strong interest in training postdocs/residents in translational science.

    Recent Publications See All Publications
    • Journal Article
      Obesity Inhibits Alveolar Macrophage Responses to Pseudomonas aeruginosa Pneumonia via Upregulation of Prostaglandin E2 in Male, but Not Female, Mice.
      Entrup GP, Unadkat A, Warheit-Niemi HI, Thomas B, Gurczynski SJ, Cui Y, Smith AM, Gallagher KA, Moore BB, Singer K. J Immunol, 2024 Jun 21; DOI:10.4049/jimmunol.2400140
      PMID: 38905107
    • Journal Article
      Scavengers in islets fuel diabetic autoimmunity.
      Moon JY, Gallagher KA. Immunity, 2024 Jul 9; 57 (7): 1448 - 1451. DOI:10.1016/j.immuni.2024.06.008
      PMID: 38986438
    • Proceeding / Abstract / Poster
      Impaired Epigenetic Reprogramming prevents Fibroblast to Myofibroblast Transition in Diabetic Wounds
      Bauer T, Mangum KD, Barrett E, Joshi A, Buckley S, Gudjonsson J, Davis F, Obi A, Moore B, Gallagher K. Journal of Vascular Surgery, 2024 Jun; 79 (6): e214 DOI:10.1016/j.jvs.2024.03.274
    • Proceeding / Abstract / Poster
      The Histone Demethylase JMJD3 Regulates Smooth Muscle Cell Phenotype during Macrophage-mediated Inflammation
      Mangum KD, Bauer T, Joshi A, Wolf-Fortune S, Moon J, Li Q, Gudjonsson J, Obi A, Davis F, Gallagher K. Journal of Vascular Surgery, 2024 Jun; 79 (6): e292 DOI:10.1016/j.jvs.2024.03.376
    • Journal Article
      Biofilm-derived oxylipin 10-HOME mediated immune response in women with breast implants.
      Bauer TM, Gallagher KA. J Clin Invest, 2024 Feb 1; 134 (3): DOI:10.1172/JCI176547
      PMID: 38299590
    • Journal Article
      Transforming the Future of Surgeon-Scientists.
      Ladner DP, Goldstein AM, Billiar TR, Cameron AM, Carpizo DR, Chu DI, Coopersmith CM, DeMatteo RP, Feng S, Gallagher KA, Gillanders WE, Lal BK, Lipshutz GS, Liu A, Maier RV, Mittendorf EA, Morris AM, Sicklick JK, Velazquez OC, Whitson BA, Wilke LG, Yoon SS, Zeiger MA, Farmer DL, Hwang ES, ASA Task Force for Research Sustainability . Ann Surg, 2024 Feb 1; 279 (2): 231 - 239. DOI:10.1097/SLA.0000000000006148
      PMID: 37916404
    • Journal Article
      Current Status and Principles for the Treatment and Prevention of Diabetic Foot Ulcers in the Cardiovascular Patient Population: A Scientific Statement From the American Heart Association.
      Gallagher KA, Mills JL, Armstrong DG, Conte MS, Kirsner RS, Minc SD, Plutzky J, Southerland KW, Tomic-Canic M, American Heart Association Council on Peripheral Vascular Disease; Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; and Council on Lifestyle and Cardiometabolic Health . Circulation, 2024 Jan 23; 149 (4): e232 - e253. DOI:10.1161/CIR.0000000000001192
      PMID: 38095068
    • Journal Article
      Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.
      Audu CO, Wolf SJ, Joshi AD, Moon JY, Melvin WJ, Sharma SB, Davis FM, Obi AT, Wasikowski R, Tsoi LC, Barrett EC, Mangum KD, Bauer TM, Kunkel SL, Moore BB, Gallagher KA. JCI Insight, 2024 Jun 24; 9 (12): DOI:10.1172/jci.insight.172959
      PMID: 38912581