David T Burke, PhD

 David T. Burke, PhD
Professor of Human Genetics
Medical School
[email protected]
Available to mentor
David T Burke, PhD
David T. Burke, PhD
Professor
  • About
  • Qualifications
  • Center Memberships
  • Research Overview
  • Recent Publications

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    • About

    Current research efforts are concentrated in three main areas: (1) development and implementation of low cost technology systems for quantitative human phenotyping, (2) development and implementation of low cost technology systems for equitable health care delivery, and (3) quantitative trait analysis of complex, multigenic, late-life and time-dependent traits.

    Qualifications
    • Howard Hughes Medical Institute Fellow
      Princeton University, Molecular Biology, Princeton, United States
      1988 - 1991
      Postdoctoral Fellowship
    • PhD
      Washington University in St. Louis School of Medicine, St Louis, MO, United States
      1982 - 1988
    • BS
      University of Rochester, Rochester, New York, United States
      1978 - 1982

    Center Memberships
    • Center Member
      Center for Global Health Equity
    • Center Member
      Weil Institute for Critical Care Research
    • Center Member
      Global REACH

    Research Overview

    The cross-disciplinary research seeks obtain longitudinal phenotype trajectories in diverse human populations to understand gene-by-environment and gene-by-time interactions. The work addresses a fundamental biological question: “What are the human genetic variations that impact the changes observed in an individual’s phenotype over their life-course?” The core strategic challenge is the use of real-world human populations to understand the genetic and environmental interactions of longitudinal biological change. The work focuses on technologies for quantitative, reproducible phenotyping of large and diverse human populations.

    Recent Publications

     See All Publications
    • Journal Article
      APOL1 genotype associated risk for preeclampsia in African populations: Rationale and protocol design for studies in women of African ancestry in resource limited settings
      Osafo C, Thomford NE, Coleman J, Carboo A, Guure C, Okyere P, Adu D, Adanu R, Parekh RS, Burke D. Plos One, 2022 Dec 1; 17 (12 December): DOI:10.1371/journal.pone.0278115
      PMID: 36580463
    • Journal Article
      Eye Drop Instillation Success and Hand Function in Adults with Glaucoma: A Pilot Study
      Weber MK, Kabil GG, Niziol LM, Urrego DD, Haire C, Cain SM, Sample AP, Burke DT, Brown SH, Newman-Casey PA. Ophthalmology Glaucoma, 2025 May 1; 8 (3): 275 - 284. DOI:10.1016/j.ogla.2024.12.008
      PMID: 40924900
    • Journal Article
      APOL1 Bi-and Monoallelic Variants and Chronic Kidney Disease in West Africans.
      Gbadegesin RA, Ulasi I, Ajayi S, Raji Y, Olanrewaju T, Osafo C, Ademola AD, Asinobi A, Winkler CA, Burke D, Arogundade F, Ekem I, Plange-Rhule J, Mamven M, Matekole M, Amodu O, Cooper R, Antwi S, Adeyemo AA, Ilori TO, Adabayeri V, Nyarko A, Ghansah A, Amira T, Solarin A, Awobusuyi O, Kimmel PL, Brosius FC, Makusidi M, Odenigbo U, Kretzler M, Hodgin JB, Pollak MR, Boima V, Freedman BI, Palmer ND, Collins B, Phadnis M, Smith J, Agwai CI, Okoye O, Abdu A, Wilson J, Williams W, Salako BL, Parekh RS, Tayo B, Adu D, Ojo A. New England Journal of Medicine, 2025 Jan 16; 392 (3): 228 - 238. DOI:10.1056/NEJMoa2404211
      PMID: 39465900
    • Journal Article
      Measuring impact of a quality improvement initiative on glaucoma clinic flow using an automated real-time locating system
      Musser JA, Cho J, Cohn A, Niziol LM, Ballouz D, Burke DT, Newman-Casey PA. BMC Ophthalmology., 2022 Aug 6; 22 (1):
    • Journal Article
      Measuring impact of a quality improvement initiative on glaucoma clinic flow using an automated real-time locating system
      Musser JA, Cho J, Cohn A, Niziol LM, Ballouz D, Burke DT, Newman-Casey PA. 2022 Aug 10; DOI:10.7302/5331
    • Journal Article
      High-depth African genomes inform human migration and health
      Choudhury A, Aron S, Botigué LR, Sengupta D, Botha G, Bensellak T, Wells G, Kumuthini J, Shriner D, Fakim YJ, Ghoorah AW, Dareng E, Odia T, Falola O, Adebiyi E, Hazelhurst S, Mazandu G, Nyangiri OA, Mbiyavanga M, Benkahla A, Kassim SK, Mulder N, Adebamowo SN, Chimusa ER, Muzny D, Metcalf G, Gibbs RA, Matovu E, Bucheton B, Hertz-Fowler C, Koffi M, Macleod A, Mumba-Ngoyi D, Noyes H, Simo G, Simuunza M, Rotimi C, Ramsay M, Botigué L, Adeyemo AA, Lombard Z, Hanchard NA, Adebamowo C, Agongo G, Boua RP, Oduro A, Sorgho H, Landouré G, Cissé L, Diarra S, Samassékou O, Anabwani G, Matshaba M, Joloba M, Kekitiinwa A, Mardon G, Mpoloka SW, Kyobe S, Mlotshwa B, Mwesigwa S, Retshabile G, Williams L, Wonkam A, Moussa A, Adu D, Ojo A, Burke D, Salako BO, Hertz-Fowler C. Nature, 2020 Oct 29; 586 (7831): 741 - 748. DOI:10.1038/s41586-020-2859-7
      PMID: 33116287
    • Journal Article
      Designing and validating a low-cost real time locating system to continuously assess patient wait times
      Newman-Casey PA, Musser J, Niziol LM, Shedden K, Burke D, Cohn A. Journal of Biomedical Informatics, 2020 Jun 1; 106: DOI:10.1016/j.jbi.2020.103428
      PMID: 32339749
    • Journal Article
      Medication adherence and liquid level tracking system for healthcare provider feedback
      Payne N, Gangwani R, Barton K, Sample A, Cain S, Burke D, Newman-Casey PA, Shorter K. Sensors Switzerland, 2020 Apr 2; 20 (8): DOI:10.3390/s20082435
      PMID: 32344754