Associate Professor of Pharmacology
Adjunct Research Associate Professor
Life Sciences Institute
[email protected]
Available to mentor
Julien Sebag
Associate Professor
Our laboratory focuses on identifying new pathways involved in the control of energy and glucose homeostasis and discovering novel targets for the treatment of obesity and diabetes. Our main focus is understanding the role and mechanism of GPCR regulation by the Melanocortin Receptor Accessory Protein 2 (MRAP2). MRAP2 is a critical protein for the maintenance of proper energy and glucose balance. Deletion of MRAP2 causes obesity and insulin resistance, however, the mechanisms involved are poorly understood. We are also studying new regulators of insulin-stimulated GLUT4 translocation using high throughput screening and structural biology.
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PhDUniversity of Rochester Medical Center, Rochester
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Center MemberCaswell Diabetes Institute
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Yin TC, Van Vranken JG, Srivastava D, Mittal A, Buscaglia P, Moore AE, Verdinez JA, Graham AE, Walsh SA, Acevedo MA, Kerns RJ, Artemyev NO, Gygi SP, Sebag JA. Cell Chem Biol, 2023 Aug 17; 30 (8): 933 - 942.e6.Journal ArticleInsulin sensitization by small molecules enhancing GLUT4 translocation.
DOI:10.1016/j.chembiol.2023.06.012 PMID: 37453421 -
Yin TC, Mittal A, Buscaglia P, Li W, Sebag JA. J Biol Chem, 2023 Jan; 299 (1): 102814Journal ArticleActivation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2.
DOI:10.1016/j.jbc.2022.102814 PMID: 36539034 -
Rouault AAJ, Buscaglia P, Sebag JA. J Biol Chem, 2022 Jun; 298 (6): 102057Journal ArticleMRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation.
DOI:10.1016/j.jbc.2022.102057 PMID: 35605660 -
Li M, Shao F, Qian Q, Yu W, Zhang Z, Chen B, Su D, Guo Y, Phan A-V, Song L-S, Stephens SB, Sebag J, Imai Y, Yang L, Cao H. Mol Ther Nucleic Acids, 2021 Dec 3; 26: 307 - 320.Journal ArticleA putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.
DOI:10.1016/j.omtn.2021.06.027 PMID: 34513312 -
Verdinez JA, Sebag JA. Front Neurosci, 2021 15: 730417Journal ArticleRole of N-Linked Glycosylation in PKR2 Trafficking and Signaling.
DOI:10.3389/fnins.2021.730417 PMID: 34483834 -
Bui TM, Butin-Israeli V, Wiesolek HL, Zhou M, Rehring JF, Wiesmüller L, Wu JD, Yang G-Y, Hanauer SB, Sebag JA, Sumagin R. Gastroenterology, 2021 Jul; 161 (1): 225 - 238.e15.Journal ArticleNeutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer.
DOI:10.1053/j.gastro.2021.03.027 PMID: 33753103 -
Yin TC, Bauchle CJ, Rouault AAJ, Stephens SB, Sebag JA. iScience, 2020 Jun 26; 23 (6): 101216Journal ArticleThe Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells.
DOI:10.1016/j.isci.2020.101216 PMID: 32535024 -
Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL. Hypertension, 2020 Feb; 75 (2): 569 - 579.Journal ArticleReduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
DOI:10.1161/HYPERTENSIONAHA.119.14056 PMID: 31865781
