Brian C Callaghan, MD, MS
Eva L Feldman M.D.
Ph.D. Professor
Professor of Neurology
Medical School
Office:
University of Michigan
Neurology
109 Zina Pitcher Pl, 4021 BSRB
Ann Arbor, Michgan 48109-2200
Neurology
109 Zina Pitcher Pl, 4021 BSRB
Ann Arbor, Michgan 48109-2200
Email:
[email protected]
Phone:
Available to mentor
Brian C Callaghan, MD, MS
Professor
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About
Dr. Callaghan is a Professor of Neurology and a neuromuscular specialist at the University of Michigan. He completed his medical degree and neurology residency at the University of Pennsylvania and completed a fellowship in neuromuscular disease at the University of Michigan. He also completed a master’s degree program in clinical research at the University of Michigan School of Public Health.
Qualifications
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FellowshipCenter for Healthcare Research and Transformation Policy, University of Michigan, Ann Arbor, Michigan, United States
2016 - 2016
Postdoctoral Fellowship
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FellowshipUniversity of Michigan Health System, Neuromuscular, Ann Arbor, Michigan, United States
2008 - 2009
Postdoctoral Fellowship
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ResidencyUniversity of Pennsylvania Medical Center, Neurology, Philadelphia, Pennsylvania, United States
2005 - 2008
Residency
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Internship, Preliminary MedicineUniversity of Pennsylvania Medical Center, Philadelphia, Pennsylvania, United States
2004 - 2005
Internship
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MSUniversity of Michigan, Ann Arbor, Michigan, United States
2009 - 2011
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MDUniversity of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, Pennsylvania, 19104, United States
2000 - 2004
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BSUniversity of Michigan, Ann Arbor, Michigan, United States
1996 - 1999
Center Memberships
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Center MemberOpioid Research Institute
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Center MemberCaswell Diabetes Institute
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Center MemberInstitute for Healthcare Policy and Innovation
Research Overview
Dr. Callaghan is interested in the treatment of painful diabetic neuropathy and other chronic pain conditions including the role of opioids. He has led the recent American Academy of Neurology guideline on the treatment of painful diabetic neuropathy and is interested in better understanding the best interventions for this common condition. Furthermore, Dr. Callaghan is interested in a better understanding of the appropriate role of opioids in chronic non cancer pain conditions.
Recent Publications
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Reynolds EL, Watanabe M, Banerjee M, Chant E, Villegas-Umana E, Elafros MA, Gardner TW, Pop-Busui R, Pennathur S, Feldman EL, Callaghan BC. Diabetologia, 2023 Jul 1; 66 (7): 1192 - 1207.Journal ArticleThe effect of surgical weight loss on diabetes complications in individuals with class II/III obesity
DOI:10.1007/s00125-023-05899-3 PMID: 36917280 -
Taams NE, Huijg M, Vermeij FH, Kuitwaard K, Hanewinckel R, de Beukelaar J, Reynolds EL, Callaghan BC, Ikram MA, van Doorn PA. J Peripher Nerv Syst, 2026 Sep; 31 (3): e70143Journal ArticleThe Erasmus-Polyneuropathy Symptom Score for the Screening of Chronic Axonal Polyneuropathy: A Validation Study.
DOI:10.1111/jns.70143 PMID: PMC13364287 -
Wiggers A, Muthukumar L, Reynolds EL, Nilsson M, Hansen CS, Rungby J, Feldman EL, Callaghan BC. Diabetes Res Clin Pract, 2026 Jul 22; 113457Journal ArticleImpact of modifiable risk factors, including diabetes, and diabetes-related complications, on dementia risk in older U.S. adults: mutually adjusted estimates from a population-based cohort.
DOI:10.1016/j.diabres.2026.113457 PMID: 42486408 -
Stino AM, Muthukumar L, Reynolds EL, Todd P, Ovunc S, Jin SC, Tang Z, Thomas S, PNRR Study Group , Höke A, Callaghan BC. Ann Clin Transl Neurol, 2026 Jul 5;Journal ArticleBi- and Mono-Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy.
DOI:10.1002/acn3.70462 PMID: 42402724 -
Hill CE, Lin CC, Harris A, Anderson-Benge E, Esper CD, Nair KV, de Havenon A, Callaghan BC, Busis NA, Esper GJ. Neurology, 2026 May 26; 106 (10): e214989Journal ArticleVirtual vs In-Person Neurologic Ambulatory Care: A Case-Control Study of Subsequent Health Care Utilization.
DOI:10.1212/WNL.0000000000214989 PMID: 42018961 -
Wiggers A, Kosjerina V, Nilsson M, Brock B, Andersen S, Reynolds EL, Callaghan BC, Feldman EL, Rungby J, Hansen CS. Diabetes Obes Metab, 2026 May 10;Journal ArticleDiabetic Peripheral Neuropathy May Be an Independent Risk Marker for Dementia and Cerebrovascular Disease.
DOI:10.1111/dom.70842 PMID: 42108425 -
Tang Z, Ovunc SS, Iwase R, Mehinovic E, Thomas S, Ulibarri J, Li Z, Baldridge D, Cruchaga C, Liu M, Johnson M, Milbrandt J, Callaghan B, PNRR Study Group , Höke A, Todd PK, Jin SC. Ann Neurol, 2026 Apr 11;Journal ArticleHomozygous RFC1 AAGGG Repeat Expansions Are Common in Idiopathic Peripheral Neuropathy.
DOI:10.1002/ana.78226 PMID: 41964406 -
Centola H, Plegue M, Albright D, Mizokami-Stout K, Ang L, Iyengar J, Hirschfeld E, Kratz A, Reynolds EL, Callaghan BC, Pop-Busui R, Lee JM. Canadian Journal of Diabetes, 2026 Apr 18;Journal ArticlePsychometric Properties of Ecological Momentary Assessment of Psychosocial Functioning in Adults with Complications Related to Type 1 Diabetes
DOI:10.1016/j.jcjd.2026.04.005
Featured News & Stories
Research News
Diabetic neuropathy linked with dementia and stroke
NeuroNetwork researchers investigated whether the increasingly common condition was associated with a higher risk of dementia and cerebrovascular disease in those with type 1 and type 2 diabetes.
Research News
Dr. Brian Callaghan to lead new study on treatment for painful diabetic neuropathy
PCORI-funded study will compare treatment modalities for patients with this debilitating condition
Research News
New exercise guidelines for neuropathy
Researchers examined how the duration and intensity of exercise affect diabetic peripheral neuropathy.
Research News
Obesity measurements and neuropathy
Researchers investigated whether obesity measurements might provide an early warning for diabetic peripheral neuropathy
Research News
Hispanics have increased risk of neuropathy
A recent study published in Neurology looked at whether race an ethnicity play a role in a person's risk of peripheral neuropathy.
Research News
The Impact of Diabetes and Metabolic Syndrome on Neuropathy
Researchers looked at how diabetes and metabolic syndrome affected pain, neuropathy severity and fiber type.
