Charles Francis Burant, MD, PhD
Dr Robert C and Veronica Atkins Professor of Metabolism
Professor of Internal Medicine
Professor of Molecular and Integrative Physiology
Director of the A Alfred Taubman Medical Research Institute at Michigan Medicine
Professor of Nutritional Sciences
Internal Medicine
6903 Brehm Tower 1000 Wall St.
Ann Arbor, MI 48109
[email protected]

Available to mentor

Charles Francis Burant, MD, PhD
Professor
  • About
  • Center Memberships
  • Research Overview
  • Recent Publications
  • About

    Charles Burant is professor of internal medicine, Section of Metabolism, Endocrinology, and Diabetes. He holds the Robert C. and Veronica Atkins Professor of Metabolism endowed chair. His clinical interests are in the care of patients with obesity, type 2 diabetes, and related conditions. Burant is the Director of the Taubman Institute, leading its mission to support the careers of clinicians who performing research as a primary focus of their academic activities as well as supporting a diverse number of muli-investigator translational research programs. He is the founding director of Director of the Michigan Metabolomics Core which provides the research community with access to cutting edge technology and informatics support to integrate metabolite profiling into their research program. Burant's personal research program centers on the interaction between genetically driven traits such as intrinsic oxidative capacity and environmental factors such as nutrients and exercise, in the development and treatment of insulin resistance, obesity and β-cell failure in both man and in animal models. Burant is a specific interest in intermediary metabolism and his laboratory combines genetics, epigenetics, metabolomics, and transcriptomics to understand the causes and phenotypic manifestation of cardiometabolic disease.

    Center Memberships
    • Center Member
      Center for Computational Medicine and Bioinformatics
    • Center Member
      Taubman Institute
    • Center Member
      Samuel and Jean Frankel Cardiovascular Center
    • Center Member
      Center for Cell Plasticity and Organ Design
    • Center Member
      Caswell Diabetes Institute
    Research Overview

    Dr. Burant's research laboratory investigates the mechanisms of insulin resistance and utilizes animal models of diabetes to identify pathways important in understanding diabetes progression. Additionally, his lab also studies adult pancreatic progenitor cells and how they might be used to generate new insulin secreting beta-cells.

    Recent Publications See All Publications
    • Journal Article
      Temporal dynamics of the multi-omic response to endurance exercise training.
      MoTrPAC Study Group , Lead Analysts , MoTrPAC Study Group . Nature, 2024 May; 629 (8010): 174 - 183. DOI:10.1038/s41586-023-06877-w
      PMID: 38693412
    • Journal Article
      Sex modulates the diet-induced changes to the plasma lipidome in a rat model of cardiorespiratory fitness.
      Fleischman JY, Casey JL, Meijer JL, Treutelaar MK, Rajendiran TM, Soni T, Evans CR, Burant CF. Biochim Biophys Acta Mol Cell Biol Lipids, 2024 Apr; 1869 (3): 159451 DOI:10.1016/j.bbalip.2024.159451
      PMID: 38191091
    • Journal Article
      Understanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop.
      Aagaard KM, Barkin SL, Burant CF, Carnell S, Demerath E, Donovan SM, Eneli I, Francis LA, Gilbert-Diamond D, Hivert M-F, LeBourgeois MK, Loos RJF, Lumeng JC, Miller AL, Okely AD, Osganian SK, Ramirez AG, Trasande L, Van Horn LV, Wake M, Wright RJ, Yanovski SZ. Obes Rev, 2024 Apr; 25 (4): e13690 DOI:10.1111/obr.13690
      PMID: 38204366
    • Preprint
      Integrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits
      Okamoto J, Yin X, Ryan B, Chiou J, Luca F, Pique-Regi R, Im HK, Morrison J, Burant C, Fauman E, Laakso M, Boehnke M, Wen X. 2024 bioRxiv, DOI:10.1101/2024.03.28.587202
    • Preprint
      Insulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation
      Schleh M, Ryan B, Ahn C, Ludzki A, Van Pelt D, Pitchford L, Chugh O, Luker A, Luker K, Samovski D, Abumrad N, Burant C, Horowitz J. 2024 bioRxiv, DOI:10.1101/2024.02.29.582589
    • Journal Article
      Genetic drivers of heterogeneity in type 2 diabetes pathophysiology.
      Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee J-J, Pan I, Taliun D, Parra EJ, Chai J-F, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak S-H, Long J, Sun M, Tong L, Chen W-M, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen C-H, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang L-C, Chee M-L, Chen J, Chen S-H, Chen Y-T, Chen Z, Chuang L-M, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt K-U, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard A-G, Hsueh W, Huang M, Huang W, Hung Y-J, Hwang MY, Hwu C-M, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang H-M, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor C-C, Kibriya MG, Kim D-H, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee M-S, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu C-T, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stančáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai F-J, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan J-M, Yusuf S, Zawistowski M, Zhang L, Zheng W, VA Million Veteran Program , Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang Y-X, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu J-Y, Hayes MG, Ma RCW, Wong T-Y, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu X-O, Park K-S, Jukema JW, Cruz M, Chen Y-DI, Rich SS, McKean-Cowdin R, Grallert H, Cheng C-Y, Ghanbari M, Tai E-S, Dupuis J, Kato N, Laakso M, Köttgen A, Koh W-P, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim B-J, Millwood IY, Walters RG, Stefansson K, Ahlqvist E, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zöllner S, Mägi R, Marston NA, Ruff CT, van Heel DA, Finer S, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang K-M, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E. Nature, 2024 Mar; 627 (8003): 347 - 357. DOI:10.1038/s41586-024-07019-6
      PMID: 38374256
    • Journal Article
      Intestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.
      Bozadjieva-Kramer N, Shin JH, Li Z, Rupp AC, Miller N, Kernodle S, Lanthier N, Henry P, Seshadri N, Myronovych A, MacDougald OA, O'Rourke RW, Kohli R, Burant CF, Rothberg AE, Seeley RJ. JCI Insight, 2024 Apr 8; 9 (7): DOI:10.1172/jci.insight.174164
      PMID: 38587078
    • Journal Article
      The mitochondrial multi-omic response to exercise training across rat tissues.
      Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul DA, Hershman SG, Ferrasse A, Xia A, Lanza I, Fernández FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group . Cell Metab, 2024 Apr 15; DOI:10.1016/j.cmet.2023.12.021
      PMID: 38701776