6903 Brehm Tower 1000 Wall St.
Ann Arbor, MI 48109
Available to mentor
Charles Burant is professor of internal medicine, Section of Metabolism, Endocrinology, and Diabetes. He holds the Robert C. and Veronica Atkins Professor of Metabolism endowed chair. His clinical interests are in the care of patients with obesity, type 2 diabetes, and related conditions. Burant is the Director of the Taubman Institute, leading its mission to support the careers of clinicians who performing research as a primary focus of their academic activities as well as supporting a diverse number of muli-investigator translational research programs. He is the founding director of Director of the Michigan Metabolomics Core which provides the research community with access to cutting edge technology and informatics support to integrate metabolite profiling into their research program. Burant's personal research program centers on the interaction between genetically driven traits such as intrinsic oxidative capacity and environmental factors such as nutrients and exercise, in the development and treatment of insulin resistance, obesity and β-cell failure in both man and in animal models. Burant is a specific interest in intermediary metabolism and his laboratory combines genetics, epigenetics, metabolomics, and transcriptomics to understand the causes and phenotypic manifestation of cardiometabolic disease.
-
Center MemberCenter for Computational Medicine and Bioinformatics
-
Center MemberTaubman Institute
-
Center MemberSamuel and Jean Frankel Cardiovascular Center
-
Center MemberCenter for Cell Plasticity and Organ Design
-
Center MemberCaswell Diabetes Institute
Dr. Burant's research laboratory investigates the mechanisms of insulin resistance and utilizes animal models of diabetes to identify pathways important in understanding diabetes progression. Additionally, his lab also studies adult pancreatic progenitor cells and how they might be used to generate new insulin secreting beta-cells.
-
MoTrPAC Study Group , Lead Analysts , MoTrPAC Study Group . Nature, 2024 May; 629 (8010): 174 - 183.Journal ArticleTemporal dynamics of the multi-omic response to endurance exercise training.
DOI:10.1038/s41586-023-06877-w PMID: 38693412 -
Fleischman JY, Casey JL, Meijer JL, Treutelaar MK, Rajendiran TM, Soni T, Evans CR, Burant CF. Biochim Biophys Acta Mol Cell Biol Lipids, 2024 Apr; 1869 (3): 159451Journal ArticleSex modulates the diet-induced changes to the plasma lipidome in a rat model of cardiorespiratory fitness.
DOI:10.1016/j.bbalip.2024.159451 PMID: 38191091 -
Aagaard KM, Barkin SL, Burant CF, Carnell S, Demerath E, Donovan SM, Eneli I, Francis LA, Gilbert-Diamond D, Hivert M-F, LeBourgeois MK, Loos RJF, Lumeng JC, Miller AL, Okely AD, Osganian SK, Ramirez AG, Trasande L, Van Horn LV, Wake M, Wright RJ, Yanovski SZ. Obes Rev, 2024 Apr; 25 (4): e13690Journal ArticleUnderstanding risk and causal mechanisms for developing obesity in infants and young children: A National Institutes of Health workshop.
DOI:10.1111/obr.13690 PMID: 38204366 -
Okamoto J, Yin X, Ryan B, Chiou J, Luca F, Pique-Regi R, Im HK, Morrison J, Burant C, Fauman E, Laakso M, Boehnke M, Wen X. 2024 bioRxiv,PreprintIntegrative analysis of the genome, transcriptome, and proteome identifies causal mechanisms of complex traits
DOI:10.1101/2024.03.28.587202 -
Schleh M, Ryan B, Ahn C, Ludzki A, Van Pelt D, Pitchford L, Chugh O, Luker A, Luker K, Samovski D, Abumrad N, Burant C, Horowitz J. 2024 bioRxiv,PreprintInsulin-mediated suppression of fatty acid release predicts whole-body insulin resistance of glucose uptake and skeletal muscle insulin receptor activation
DOI:10.1101/2024.02.29.582589 -
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A, Melloni GEM, Kanoni S, Rayner NW, Bocher O, Arruda AL, Sonehara K, Namba S, Lee SSK, Preuss MH, Petty LE, Schroeder P, Vanderwerff B, Kals M, Bragg F, Lin K, Guo X, Zhang W, Yao J, Kim YJ, Graff M, Takeuchi F, Nano J, Lamri A, Nakatochi M, Moon S, Scott RA, Cook JP, Lee J-J, Pan I, Taliun D, Parra EJ, Chai J-F, Bielak LF, Tabara Y, Hai Y, Thorleifsson G, Grarup N, Sofer T, Wuttke M, Sarnowski C, Gieger C, Nousome D, Trompet S, Kwak S-H, Long J, Sun M, Tong L, Chen W-M, Nongmaithem SS, Noordam R, Lim VJY, Tam CHT, Joo YY, Chen C-H, Raffield LM, Prins BP, Nicolas A, Yanek LR, Chen G, Brody JA, Kabagambe E, An P, Xiang AH, Choi HS, Cade BE, Tan J, Broadaway KA, Williamson A, Kamali Z, Cui J, Thangam M, Adair LS, Adeyemo A, Aguilar-Salinas CA, Ahluwalia TS, Anand SS, Bertoni A, Bork-Jensen J, Brandslund I, Buchanan TA, Burant CF, Butterworth AS, Canouil M, Chan JCN, Chang L-C, Chee M-L, Chen J, Chen S-H, Chen Y-T, Chen Z, Chuang L-M, Cushman M, Danesh J, Das SK, de Silva HJ, Dedoussis G, Dimitrov L, Doumatey AP, Du S, Duan Q, Eckardt K-U, Emery LS, Evans DS, Evans MK, Fischer K, Floyd JS, Ford I, Franco OH, Frayling TM, Freedman BI, Genter P, Gerstein HC, Giedraitis V, González-Villalpando C, González-Villalpando ME, Gordon-Larsen P, Gross M, Guare LA, Hackinger S, Hakaste L, Han S, Hattersley AT, Herder C, Horikoshi M, Howard A-G, Hsueh W, Huang M, Huang W, Hung Y-J, Hwang MY, Hwu C-M, Ichihara S, Ikram MA, Ingelsson M, Islam MT, Isono M, Jang H-M, Jasmine F, Jiang G, Jonas JB, Jørgensen T, Kamanu FK, Kandeel FR, Kasturiratne A, Katsuya T, Kaur V, Kawaguchi T, Keaton JM, Kho AN, Khor C-C, Kibriya MG, Kim D-H, Kronenberg F, Kuusisto J, Läll K, Lange LA, Lee KM, Lee M-S, Lee NR, Leong A, Li L, Li Y, Li-Gao R, Ligthart S, Lindgren CM, Linneberg A, Liu C-T, Liu J, Locke AE, Louie T, Luan J, Luk AO, Luo X, Lv J, Lynch JA, Lyssenko V, Maeda S, Mamakou V, Mansuri SR, Matsuda K, Meitinger T, Melander O, Metspalu A, Mo H, Morris AD, Moura FA, Nadler JL, Nalls MA, Nayak U, Ntalla I, Okada Y, Orozco L, Patel SR, Patil S, Pei P, Pereira MA, Peters A, Pirie FJ, Polikowsky HG, Porneala B, Prasad G, Rasmussen-Torvik LJ, Reiner AP, Roden M, Rohde R, Roll K, Sabanayagam C, Sandow K, Sankareswaran A, Sattar N, Schönherr S, Shahriar M, Shen B, Shi J, Shin DM, Shojima N, Smith JA, So WY, Stančáková A, Steinthorsdottir V, Stilp AM, Strauch K, Taylor KD, Thorand B, Thorsteinsdottir U, Tomlinson B, Tran TC, Tsai F-J, Tuomilehto J, Tusie-Luna T, Udler MS, Valladares-Salgado A, van Dam RM, van Klinken JB, Varma R, Wacher-Rodarte N, Wheeler E, Wickremasinghe AR, van Dijk KW, Witte DR, Yajnik CS, Yamamoto K, Yamamoto K, Yoon K, Yu C, Yuan J-M, Yusuf S, Zawistowski M, Zhang L, Zheng W, VA Million Veteran Program , Raffel LJ, Igase M, Ipp E, Redline S, Cho YS, Lind L, Province MA, Fornage M, Hanis CL, Ingelsson E, Zonderman AB, Psaty BM, Wang Y-X, Rotimi CN, Becker DM, Matsuda F, Liu Y, Yokota M, Kardia SLR, Peyser PA, Pankow JS, Engert JC, Bonnefond A, Froguel P, Wilson JG, Sheu WHH, Wu J-Y, Hayes MG, Ma RCW, Wong T-Y, Mook-Kanamori DO, Tuomi T, Chandak GR, Collins FS, Bharadwaj D, Paré G, Sale MM, Ahsan H, Motala AA, Shu X-O, Park K-S, Jukema JW, Cruz M, Chen Y-DI, Rich SS, McKean-Cowdin R, Grallert H, Cheng C-Y, Ghanbari M, Tai E-S, Dupuis J, Kato N, Laakso M, Köttgen A, Koh W-P, Bowden DW, Palmer CNA, Kooner JS, Kooperberg C, Liu S, North KE, Saleheen D, Hansen T, Pedersen O, Wareham NJ, Lee J, Kim B-J, Millwood IY, Walters RG, Stefansson K, Ahlqvist E, Goodarzi MO, Mohlke KL, Langenberg C, Haiman CA, Loos RJF, Florez JC, Rader DJ, Ritchie MD, Zöllner S, Mägi R, Marston NA, Ruff CT, van Heel DA, Finer S, Denny JC, Yamauchi T, Kadowaki T, Chambers JC, Ng MCY, Sim X, Below JE, Tsao PS, Chang K-M, McCarthy MI, Meigs JB, Mahajan A, Spracklen CN, Mercader JM, Boehnke M, Rotter JI, Vujkovic M, Voight BF, Morris AP, Zeggini E. Nature, 2024 Mar; 627 (8003): 347 - 357.Journal ArticleGenetic drivers of heterogeneity in type 2 diabetes pathophysiology.
DOI:10.1038/s41586-024-07019-6 PMID: 38374256 -
Bozadjieva-Kramer N, Shin JH, Li Z, Rupp AC, Miller N, Kernodle S, Lanthier N, Henry P, Seshadri N, Myronovych A, MacDougald OA, O'Rourke RW, Kohli R, Burant CF, Rothberg AE, Seeley RJ. JCI Insight, 2024 Apr 8; 9 (7):Journal ArticleIntestinal FGF15 regulates bile acid and cholesterol metabolism but not glucose and energy balance.
DOI:10.1172/jci.insight.174164 PMID: 38587078 -
Amar D, Gay NR, Jimenez-Morales D, Jean Beltran PM, Ramaker ME, Raja AN, Zhao B, Sun Y, Marwaha S, Gaul DA, Hershman SG, Ferrasse A, Xia A, Lanza I, Fernández FM, Montgomery SB, Hevener AL, Ashley EA, Walsh MJ, Sparks LM, Burant CF, Rector RS, Thyfault J, Wheeler MT, Goodpaster BH, Coen PM, Schenk S, Bodine SC, Lindholm ME, MoTrPAC Study Group . Cell Metab, 2024 Apr 15;Journal ArticleThe mitochondrial multi-omic response to exercise training across rat tissues.
DOI:10.1016/j.cmet.2023.12.021 PMID: 38701776