Available to mentor
My clinical interests include the complex set of head and neck cancers comprised of HPV mediated
oropharyngeal tumors, HPV negative tumors of the oropharynx, oral cavity, hypopharynx, and larynx as
well as salivary gland tumors, sinonasal tumors and advanced cutaneous malignancies. I also specialize
in robotic surgery for oropharyngeal tumors and in reconstructive surgery to restore form and function for
patients undergoing cancer treatment.
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Resident PhysicianUniversity of Michigan Medical School, Otolaryngology Head and Neck Surgery, 2022
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T32 Research FellowshipUniversity of Michigan–Ann Arbor, Otolaryngology Head and Neck Surgery, 2020
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FellowshipWashington University in St. Louis School of Medicine, Head and Neck Surgery- Microvascular Reconstruction
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MDUniversity of Pittsburgh School of Medicine, Pittsburgh, 2016
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BSStanford University, Stanford, 2011
My research interests focus on translational questions in head and neck oncology. Specific areas of focus
include understanding the how hypoxia drives radiation and chemoradiation failure in HPV-mediated
oropharyngeal tumors and predictors of failure in larynx cancer in patients undergoing organ preserving
therapy. Utilizing novel techniques including liquid biopsies and single cell sequencing, our group is
striving to better understand the tumor microenvironment, tumor mutational signatures, and immune
landscape that predict treatment failure. From a clinical perspective my research focuses on outcomes of
HPV-mediated treatments in the setting of ongoing de-escalation trials to improve predictions of functional
outcomes such as speech and swallowing after treatment.
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Smith B, Rosko A, VanKoevering KK, Heft Neal M, Ellsperman S, Fenberg RB, Cho J, Vita A, Feng AL, Contrera KJ, Sridharan SS, Spector ME. Oral Oncol, 2024 Oct; 157: 106960Journal Article3D modeling of anterior 2/3rds glossectomy reconstruction: A volume based donor site evaluation.
DOI:10.1016/j.oraloncology.2024.106960 PMID: 39068767 -
Prince ADP, Heft Neal ME, Buchakjian MR, Chinn SB, Stucken CL, Casper KA, Malloy KM, Prince MEP, Rosko AJ, McHugh JB, Spector ME. Otolaryngol Head Neck Surg, 2024 Sep; 171 (3): 785 - 790.Journal ArticlePharyngeal Mucosal Margin Vessel Counts Predict Pharyngocutaneous Fistula in Salvage Laryngectomy.
DOI:10.1002/ohn.865 PMID: 38881401 -
Benjamin WJ, Feng AL, Heft Neal M, Bellile E, Casper KA, Malloy KM, Rosko AJ, Stucken CL, Prince ME, Mierzwa ML, Taylor JMG, Eisbruch A, Spector ME, Wolf GT, Swiecicki PL, Worden FP, Chinn SB. Oral Oncol, 2024 Sep; 156: 106917Journal ArticleUtility of bioselection with neoadjuvant chemotherapy for organ preservation in patients with T4 laryngeal cancer.
DOI:10.1016/j.oraloncology.2024.106917 PMID: 38945011 -
Heft Neal ME, Haring CT, Bellile E, Jaffe CC, Shuman AG, Chinn SB, Stucken CL, Malloy KM, Casper KA, Prince MEP, Chepeha DB, Rosko AJ, Spector ME. Clin Cancer Res, 2024 Jul 15; 30 (14): 2910 - 2916.Journal ArticlePhase II Clinical Trial of Intravenous Levothyroxine to Mitigate Pharyngocutaneous Fistula in Euthyroid Patients Undergoing Salvage Laryngectomy.
DOI:10.1158/1078-0432.CCR-24-0782 PMID: 38723280 -
Haring CT, Heft Neal ME, Jaffe CA, Shuman AG, Rosko AJ, Spector ME. Am J Surg, 2024 Jun; 232: 107 - 111.Journal ArticleAssociation of preoperative thyroid hormone replacement with perioperative complications after major abdominal surgery.
DOI:10.1016/j.amjsurg.2024.01.018 PMID: 38311517 -
Dermody S, Brummel C, Brenner C, Casper K, Chinn SB, Malloy KM, Mierzwa ML, Neal MH, Prince M, Shah JL, Shuman A, Stucken C, Spector M, Worden FP, Swiecicki P. Journal of Clinical Oncology, 2024 Jun 1; 42 (16_suppl): 6102 - 6102.Journal ArticleClinical outcomes in salivary adenoid cystic carcinoma.
DOI:10.1200/jco.2024.42.16_suppl.6102 -
Swiecicki PL, Bellile E, Dragovic AF, McHugh J, Udager A, Mierzwa ML, Shah J, Heft-Neal M, Rosko A, Malloy KM, Casper K, Chinn SB, Shuman AG, Stucken C, Chepeha DB, Wolf GT, Bradford CR, Eisbruch A, Prince ME, Worden FP, Spector ME. Clin Cancer Res, 2024 Jun 3; 30 (11): 2393 - 2401.Journal ArticleUpfront Neck Dissection for Treatment Selection and Improvement in Quality of Life as a Novel Treatment Paradigm for Deintensification in HPV+ OPSCC.
DOI:10.1158/1078-0432.CCR-23-3247 PMID: 38517480 -
Smith JD, Heft-Neal ME, Rosko AJ, Chepeha DB, Spector ME. Oral Oncol, 2024 May; 152: 106803Journal ArticleUpfront neck dissection to guide single-modality therapy for early stage supraglottic squamous cell carcinoma.
DOI:10.1016/j.oraloncology.2024.106803 PMID: 38613849